Search results for "nash"

showing 10 items of 141 documents

The grass is always greener on the other side of the fence: the effect of misperceived signalling in a network formation process

2007

Social and economic networks are becoming increasingly popular in the last ten years, because of both the application of game theory to the network formation processes4, and the study of stochastic processes that fit the statistical properties of real world social networks.5 In the very recent years there have also been attempts to combine the contribution of these two streams of research, trying to find strategic models whose equilibria resemble the empirical data.6 A well known source of debate in the game theoretical approach is the incompatibility between stability and efficiency: in most of the models Nash equilibria are actually not the network architectures that maximize the overall …

Network architectureEngineeringEconophysicsProcess (engineering)business.industryStochastic processStability (learning theory)Network formationNETWORKSTransport engineeringsymbols.namesakeNash equilibriumsymbolsnetwork formation segregationbusinessMathematical economicsGame theory
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Need for liver evaluation in polycystic ovary syndrome

2007

Medicine is changing and requires a more in-depth knowledge also in fields that were previously considered completely different and dedicated to other specialists. A good example of this general trend is the paper by Cerda et al. [1] that shows a high prevalence of nonalcoholic fatty liver disease (NAFLD) in women with Polycystic Ovary Syndrome (PCOS). The authors studied 41 young women with PCOS and found that 17 patients (41%) had NAFLD. In addition, 7 patients with NAFLD had increased aminotransferase levels raising the possibility of a transition to nonalcoholic steatohepatitis (NASH). Other reports have shown similar data recently [2–5]. It is time therefore that doctors caring for pat…

Nonalcoholic steatohepatitisMetabolic Syndromemedicine.medical_specialtySettore MED/12 - GastroenterologiaSettore MED/09 - Medicina InternaHepatologyPCOS Liver function NASH NAFLDbusiness.industrynutritional and metabolic diseasesmedicine.diseaseGastroenterologyPolycystic ovarySettore MED/13 - EndocrinologiaFatty LiverLiver Function TestsInternal medicineNonalcoholic fatty liver diseasePrevalenceMedicineHumansFemalebusinessPolycystic Ovary Syndrome
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Endogenous R&D Symmetry in Linear Duopoly with One-way Spillovers

2005

A duopoly model of cost reducing R&D-Cournot market competition is extended to encompass endogenous timing of R&D investments. Under the assumption that R&D spillovers are zero under simultaneous choices of R&D and only flow from the R&D leader to the follower under sequential choices, sequential and simultaneous play at the R&D stage are compared in order to assess the role of technological externalities in stimulating or attenuating endogenous firm asymmetry. The only timing structure of the R&D stage sustainable as subgame–perfect Nash equilibrium involves simultaneous play and thus zero spillovers.

Organizational Behavior and Human Resource ManagementEconomics and EconometricsStackelberg equilibriumEndogenous timingmedia_common.quotation_subjectjel:D43Settore SECS-P/06 - Economia ApplicataAsymmetryCompetition (economics)Microeconomicssymbols.namesakeStrategic investmentR&D with spillovers Firm AsymmetryStackelberg competitionEconomicsDuopolymedia_commonjel:C72Endogenous symmetryendogenous symmetry endogenous timing Stackelberg equilibriumjel:L11Nash equilibriumjel:L13symbolsendogenous timing stackelberg equilibriumSymmetry (geometry)Mathematical economicsSSRN Electronic Journal
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

2022

Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods We profiled 2,083 serum miRNAs in a discovery cohort (183 cases with NAFLD representing the complete NAFLD spectrum and 10 population controls). miRNA libraries generated by HTG EdgeSeq were sequenced by Illumina NextSeq. Selected serum miRNAs were profiled in 372 additional cases with NAFLD and 15 population controls by quantitative reverse transcriptase PCR. Results Levels of 275 miRNAs differed between cases and population controls. Fewer differences were seen wi…

SCORING SYSTEMCPM counts per millionAUROC area under the receiver operating characteristicRC799-869AST aspartate aminotransferaseMicroRNA; Non-alcoholic fatty liver disease; Biomarker; SequencingTGF-β transforming growth factor-betaGastroenterologySTEATOHEPATITISLiver disease0302 clinical medicineFibrosismiRNA microRNAlogFC log2 fold changeFIBROSISImmunology and AllergySequencing0303 health scienceseducation.field_of_studyNAS NAFLD activity scoremedicine.diagnostic_testFatty liverGastroenterologyGTEx Genotype-Tissue ExpressionMicroRNADiseases of the digestive system. Gastroenterology3. Good healthReal-time polymerase chain reactionBiomarker MicroRNA Non-alcoholic fatty liver disease SequencingLiver biopsyACIDBiomarker (medicine)030211 gastroenterology & hepatologyLife Sciences & BiomedicineResearch ArticleEXPRESSIONmedicine.medical_specialtyNAFLD non-alcoholic fatty liver diseaseNASH non-alcoholic steatohepatitisPopulationGastroenterology and HepatologySAF steatosis–activity–fibrosisVALIDATIONER endoplasmic reticulum03 medical and health sciencescDNA complementary DNAInternal medicineALT alanine aminotransferaseGastroenterologiInternal MedicinemedicineNAFL non-alcoholic fatty liverALGORITHMFIB-4 fibrosis-4education030304 developmental biologyPCA principal component analysisScience & TechnologyGastroenterology & HepatologyHepatologybusiness.industryBiomarkerFC fold changemedicine.diseaseBiomarker; MicroRNA; Non-alcoholic fatty liver disease; Sequencingdigestive system diseasesFLIP fatty liver inhibition of progressionCt cycle thresholdSteatosisqPCR quantitative PCRbusinessNon-alcoholic fatty liver disease
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Correlation between the single nucleotide polymorphism (SNP) rs4374383 in MERTK gene with the risk of development and progression of liver disease

Settore BIO/13 - Biologia Applicatachronic hepatitis B and C NASH NAFLD MERTK GENE HEPATOCELLULAR CARCINOMA GENETIC FACTORS HSCs FIBROSIS HCV CIRRHOSIS HBV CIRRHOSIS LIVER KUPPER CELLS TAMs SNP
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Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease

2023

Background and aims: Programmed cell death 1/programmed cell death-ligand 1 (PD-1/PDL-1) axis has been reported to modulate liver inflammation and progression to hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease (NAFLD). Here, we examined whether the PDCD1 variation is associated with NAFLD severity in individuals with liver biopsy. Methods: We examined the impact of PDCD1 gene variants on HCC, as robust severe liver disease phenotype in UK Biobank participants. The strongest genetic association with the rs13023138 G>C variation was subsequently tested for association with liver damage in 2889 individuals who underwent liver biopsy for suspected nonalcoholi…

Settore MED/12 - GastroenterologiaHepatologySettore BIO/13 - Biologia ApplicataGastroenterologyCXCR6 NAFLD NASH PDCD1 checkpoint inhibitorsDigestive and Liver Disease
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A Network Formation Game Approach to Study BitTorrent Tit-for-Tat

2007

The Tit-for-Tat strategy implemented in BitTorrent (BT) clients is generally considered robust to selfish behaviours. The authors of [1] support this belief studying how Tit-for-Tat can affect selfish peers who are able to set their upload bandwidth. They show that there is a "good" Nash Equilibrium at which each peer uploads at the maximum rate. In this paper we consider a different game where BT clients can change the number of connections to open in order to improve their performance. We study this game using the analytical framework of network formation games [2]. In particular we characterize the set of pairwise stable networks the peers can form and how the peers can dynamically reach…

Star networkComputer sciencebusiness.industryDistributed computingcomputer.file_formatNetwork formationTit for tatUploadsymbols.namesakeNash equilibriumsymbolsPairwise comparisonSet (psychology)businessBitTorrentcomputerComputer network
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Robust Mean Field Games

2015

Recently there has been renewed interest in large-scale games in several research disciplines, with diverse application domains as in the smart grid, cloud computing, financial markets, biochemical reaction networks, transportation science, and molecular biology. Prior works have provided rich mathematical foundations and equilibrium concepts but relatively little in terms of robustness in the presence of uncertainties. In this paper, we study mean field games with uncertainty in both states and payoffs. We consider a population of players with individual states driven by a standard Brownian motion and a disturbance term. The contribution is threefold: First, we establish a mean field syste…

Statistics and Probabilitygame theory0209 industrial biotechnologyEconomics and EconometricsMathematical optimizationPopulationCloud computing02 engineering and technology01 natural sciencessymbols.namesake020901 industrial engineering & automationResource (project management)Wiener processSettore ING-INF/04 - AutomaticaRobustness (computer science)0101 mathematicseducationMathematicseducation.field_of_studybusiness.industryApplied Mathematics010102 general mathematicsComputer Graphics and Computer-Aided DesignComputer Science ApplicationsTerm (time)Computational MathematicsSmart gridComputational Theory and MathematicsNash equilibriumsymbolsmean field gamestochastic optimal controlSettore MAT/09 - Ricerca OperativabusinessMathematical economics
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Optimizing channel selection for cognitive radio networks using a distributed Bayesian learning automata-based approach

2015

Consider a multi-channel Cognitive Radio Network (CRN) with multiple Primary Users (PUs), and multiple Secondary Users (SUs) competing for access to the channels. In this scenario, it is essential for SUs to avoid collision among one another while maintaining efficient usage of the available transmission opportunities. We investigate two channel access schemes. In the first model, an SU selects a channel and sends a packet directly without Carrier Sensing (CS) whenever the PU is absent on this channel. In the second model, an SU invokes CS in order to avoid collision among co-channel SUs. For each model, we analyze the channel selection problem and prove that it is a so-called "Exact Potent…

Theoretical computer scienceLearning automataComputer sciencebusiness.industryNetwork packet020206 networking & telecommunications02 engineering and technologyBayesian inferenceAutomatonsymbols.namesakeCognitive radioTransmission (telecommunications)Artificial IntelligenceNash equilibrium0202 electrical engineering electronic engineering information engineeringsymbols020201 artificial intelligence & image processingArtificial intelligencebusinessCommunication channelApplied Intelligence
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