Search results for "naïve"
showing 10 items of 12 documents
Disturbed brain activation during a working memory task in drug-naive adult patients with ADHD.
2010
Neuroimaging studies in attention-deficit/hyperactivity disorder (ADHD) have shown abnormalities in several brain areas including the frontostriatal circuitry and were mostly conducted in children and adolescents. We investigated 30 never-medicated adult ADHD patients (16 males) and 30 matched healthy control individuals. Functional magnetic resonance imaging was acquired during a working memory paradigm (n-back). Group activation maps and group differences of activation were calculated using voxel-based analyses. The generic activation pattern was more extended in the control group. In ADHD patients, significantly decreased activation was found in the right inferior parietal cortex. Distur…
Dynamics and molecular evolution of HIV-1 strains in Sicily among antiretroviral naïve patients.
2012
Abstract HIV-1 subtype B is the most frequent strain in Sicily. To date, there is no available data about the genetic diversity of HIV-1 viral strains circulating in Sicily among antiretroviral (ARV) naive subjects and the role of immigration as potential determinant of evolutionary dynamics of HIV-1 molecular epidemiology. For this purpose, HIV-1 polymerase (pol) sequences obtained from 155 ARV naive individuals from 2004 to 2009 were phylogenetically analysed. The overall rate of HIV-1 non-B infections was 31.0% (n = 48/155), increasing from 7.8% in 2004–2006 to 40.9% in 2009, and about one-third were identified as unique recombinant forms. CRF02_AG was the prevalent non-B clade (n = 28/4…
Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive …
2012
Background: The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore expected to revert quickly. Compensatory mutations, often already polymorphic in wild-type viruses, do not tend to revert after transmission. While compensatory mutations increase fitness during treatment, their presence may also modulate viral fitness and virulence in absence of therapy and major resistance mutations. We previously designed a modeling technique that quantifies genotypic footprints of in vivo treatment selective pressure, including both drug …
Two-year effectiveness and safety of golimumab in ulcerative colitis: An IG-IBD study
2020
Abstract Background Few data exist regarding the long‐term effectiveness of golimumab in ulcerative colitis. No data have been reported on real‐world continuous clinical response. Objective This study aimed to describe the long‐term outcomes in a large cohort of patients on golimumab who had ulcerative colitis. Methods Consecutive patients with active ulcerative colitis, started on golimumab, were enrolled and prospectively followed up. The primary end point was to evaluate the long‐term persistence on golimumab therapy. Results A total of 173 patients with ulcerative colitis were studied. Of these, 79.2% were steroid dependent, and 46.3% were naïve to anti‐tumour necrosis factor alpha agen…
Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study
2012
Identification of predictors of cardiovascular risk can help in the prevention of pathologic episodes and the management of patients at all stages of illness. Here, we investigated the relationships between serum levels of Hsp60 and dyslipidemia in patients with periodontitis by performing a cross-sectional study of 22 patients with mild periodontitis without any prior treatment for it (i.e., drug naive) and 22 healthy controls, matched for age and body mass index (BMI). All subjects were evaluated for periodontal status, gingival inflammation, and oral hygiene. Levels of circulating Hsp60, C-reactive protein (CRP), and plasma lipids were measured, and small, dense low-density lipoproteins …
Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes
2020
Metformin is the first-line pharmacotherapy for managing type 2 diabetes (T2D). However, many patients with T2D do not respond to or tolerate metformin well. Currently, there are no phenotypes that successfully predict glycemic response to, or tolerance of, metformin. We explored whether blood-based epigenetic markers could discriminate metformin response and tolerance by analyzing genome-wide DNA methylation in drug-naïve patients with T2D at the time of their diagnosis. DNA methylation of 11 and 4 sites differed between glycemic responders/nonresponders and metformin-tolerant/intolerant patients, respectively, in discovery and replication cohorts. Greater methylation at these sites associ…
From Carneades to Cicero
2015
This chapter is about how Stoic epistemology developed in the two centuries after Chrysippus’ death. I first show that, as a result of Carneades’ critique in the mid-second century, there was a shift of emphasis in the epistemological debate between the Stoa and the Academy. From then on the task was not to explain what causal features a cognitive thought has, but to describe what phenomenological features it has. I show that the later Stoics responded to this challenge in two different ways. Some changed Chrysippus’ theory quite radically. They held that a cognitive thought is characterized by giving rise to a sense of conviction, denied that preconceptions count as cognitive thoughts, and…
Contribution of Multi-Agent Systems and Fuzzy logic to support tutors in Learning Communities
2016
The growing importance of online training has put emphasis on the role of remote tutoring. A whole new area of research, dedicated to environment for human learning (EHL), is emerging. We are concerned with this field. More specifically, we will focus on the monitoring of learners.The instrumentation and observation of learners activities by exploiting interaction traces in the EHL and the development of indicators can help tutors to monitor activities of learners and support them in their collaborative learning process. Indeed, in a learning situation, the teacher needs to observe the behavior of learners in order to build an idea about their involvement, preferences and learning styles so…
Symphysis. Patocka face à ‘‘l’empirie trop grossière et naïve’’ d’Aristote
2014
International audience
Dimensions of the Relationship between the Individual and Her Unique Worldview Construction
2021
Each individual constructs his own private worldview using elements from established worldview traditions. The biographical character of this formation makes this the individual’s “Unique Worldview Construction” (UWC). The purpose of this theoretical study is to analyse the dynamic relationship between the individual and her own UWC. It describes more how than what he believes in or denies. The variation is exceedingly complex. To make it accessible, the complexity is crystallized into seven dimensions: (1) The authority structure deals with the individual’s perception of herself as being superordinate/subordinate to her own UWC. (2) The importance dimension analyses the span from indiffere…