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Lasītprasmes DIBELS Next testa latviešu versijas radītāju dinamika 3. klases skolēniem 2012./2013. un 2017./2018. mācību gadā
2018
Maģistra darba mērķis bija pētīt kā ir mainījies lasīšanas raitums un lasītā izpratne dinamikā 3.klases skolēniem no rudens līdz ziemas mērījumam 2012./2013., salīdzinot ar 2017./2018. mācību gadu. Pētījumā izmantoti dati tika ievākti 2012./2013.mācību gadā un 2017./2018. mācību gadā. Pētījumā piedalījās dažādu Latvijas vispārizglītojošo skolu 3.klases skolēni, 2012./2013. mācību gadā - 160 skolēni un 2017./2018.mācību gadā – 167 skolēni. Pētījumā izmantotās metodes: Agrīnās lasītprasmes attīstības radītāji DIBELS Next 3. klasei, latviešu versija (Raščevska, M., Orlovska, M., Griškēviča I., Ozola, E., Vabale, A., Legzdiņš, P., 2013). Galvenie secinājumi: kopumā lasītprasmes rādītāju dinamik…
Neoantigens Generated by Individual Mutations and Their Role in Cancer Immunity and Immunotherapy
2017
Recent preclinical and clinical studies have proved the long-standing hypothesis that tumors elicit adaptive immune responses and that the antigens driving effective T-cell response are neoantigens, i.e., peptides that are generated from somatically mutated genes. Hence, the characterization of neoantigens and the identification of the immunogenic ones are of utmost importance for improving cancer immunotherapy and broadening its efficacy to a larger fraction of patients. In this review, we first introduce the methods used for the quantification of neoantigens using next-generation sequencing data and then summarize results obtained using these tools to characterize the neoantigen landscape…
Diagnosis of exon 12‐positive polycythemia vera rescued by NGS
2020
Abstract A JAK2V617F‐negative polycythemia associated with low serum epo needs to be tested for an exon 12 JAK2 mutation. When negative, due to potential serious complications in PV, a next generation sequencing is necessary to rule out false negative results.
The NEXT Project: Towards Production and Investigation of Neutron-Rich Heavy Nuclides
2022
The heaviest actinide elements are only accessible in accelerator-based experiments on a one-atom-at-a-time level. Usually, fusion–evaporation reactions are applied to reach these elements. However, access to the neutron-rich isotopes is limited. An alternative reaction mechanism to fusion–evaporation is multinucleon transfer, which features higher cross-sections. The main drawback of this technique is the wide angular distribution of the transfer products, which makes it challenging to catch and prepare them for precision measurements. To overcome this obstacle, we are building the NEXT experiment: a solenoid magnet is used to separate the different transfer products and to focus those of …
ESWL Prediction of outcome and failure Prevention
2007
Based on our own experiences and a review of the recent literature, this article evaluates recent developments in predicting outcomes and failures of shockwave lithotripsy when treating patients with urinary tract stones. After a detailed MEDLINE research, the authors identified several variables that influence and predict extracorporeal shockwave lithotripsy (ESWL) success. These variables may be categorized as stone variables, patient variables and operator variables. Only multivariate analysis on a large number of homogenous patients may offer an objective evaluation of the factors conditioning ESWL outcome.
L’attività normativa del governo nel periodo 2020-2021
2022
L’articolo descrive l’attività normativa del governo nel periodo 2020-2021. Il biennio è stato segnato dalle misure di contrasto alla pandemia da Covid-19. Di conseguenza, si prendono in considerazione, innanzitutto, le misure sanitarie adottate nel periodo emergenziale e concernenti tanto gli obblighi di distanziamento fisico e di contenimento dell’epidemia, quanto le disposizioni relative alle vaccinazioni e alla presentazione del «certificato verde» o green pass. Successivamente, si dà conto delle principali normative adottate a supporto dell’economia e del sistema imprenditoriale, distinguendo tra gli ausili finanziari destinati a ridurre l’impatto negativo della pandemia sulle aziende …
Event reconstruction in NEXT using a ML-EM algorithm
2017
La desintegración doble beta sin neutrinos es un proceso hipotético en el que dos neutrones de un núcleo se transforman en dos protones emitiendo únicamente dos electrones, sin neutrinos. La detección de un proceso así demostraría que los neutrinos son partículas de Majorana y que el número leptónico total no se conserva (las oscilaciones de neutrinos ya han demostrado que el número leptónico por familia no se conserva). La determinación de la naturaleza del neutrino podría responder a varias preguntas de diversa índole dentro de la física de partículas. Primero, podría dar explicación a la escala de masas del neutrino a través de un mecanismo de balancín (see-saw). Por…
The NEXT experiment for neutrinoless double beta decay searches
2015
211 páginas. Tesis Doctoral del Departamento de Física Atómica, Molecular y Nuclear, de la Universidad de Valencia y del Instituto de Física Corpuscular (IFIC).
Systemic circulating microRNA landscape in Lynch syndrome
2022
AbstractMicroRNAs (miRs) are non-coding RNA-molecules that regulate gene expression. Global circulating miR (c-miR) expression patterns (c-miRnome) change with carcinogenesis in various sporadic cancers. Therefore, aberrantly expressed c-miRs could have diagnostic, predictive and prognostic potential in molecular profiling of cancers. c-miR functions in carriers of inherited pathogenic mismatch-repair gene variants (path_MMR), also known as Lynch syndrome (LS), have remained understudied. LS cohort provides an ideal population for biomarker mining due to increased lifelong cancer risk and excessive cancer occurrence. Using high-throughput sequencing and bioinformatic approaches, we conducte…
Aplicacions de Next Generation Sequencing en organismes no model: caracterització dels transcriptomes de verins de serps
2015
Tesis doctoral. 213 páginas. Figuras, bibliografía y anexos.