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showing 10 items of 178 documents
Transcriptome profiling of citrus fruit response to huanglongbing disease.
2010
Huanglongbing (HLB) or "citrus greening" is the most destructive citrus disease worldwide. In this work, we studied host responses of citrus to infection with Candidatus Liberibacter asiaticus (CaLas) using next-generation sequencing technologies. A deep mRNA profile was obtained from peel of healthy and HLB- affected fruit. It was followed by pathway and protein-protein network analysis and quantitative real time PCR analysis of highly regulated genes. We identified differentially regulated pathways and constructed networks that provide a deep insight into the metabolism of affected fruit. Data mining revealed that HLB enhanced transcription of genes involved in the light reactions of phot…
Autonomie e controlli della Corte dei conti nel quadro dei principi costituzionali e dei vincoli sovranazionali in materia economico-finanziaria
2022
Una riflessione dei controlli sulle autonomie territoriali intestati alla Corte dei conti non può prescindere dal loro inquadramento costituzionale. L’A. prospetta una ricostruzione del controllo come espressione di una funzione neutra e imparziale che deve riposare su precisi parametri costituzionali che ne legittimano l’adozione e di cui va resa una stretta interpretazione: il controllo sulle Autonomie territoriali deve così essere necessariamente una attività tale da avvicinarla a quella giurisdizionale piuttosto che amministrativa. È in tale chiave che deve essere inteso il rapporto fra ausiliarietà di cui all’art. 100 Cost. e controlli sui bilanci ed i rendiconti. L’evoluzione del quad…
Conditions and strategies to meet the challenges imposed by the COVID-19-related visiting restrictions in the intensive care unit: A Scandinavian cro…
2022
ObjectivesTo examine conditions and strategies to meet the challenges imposed by the coronavirus disease 2019 (COVID-19)-related visiting restrictions in Scandinavian intensive care units.Research methodology/designA cross-sectional survey.SettingAdult intensive care units in Denmark, Norway and Sweden.Main outcome measuresLikert scale responses and free-text comments within six areas: capacity and staffing, visiting policies and access to the unit, information and conferences with relatives, written information, children as relatives and follow-up initiatives.ResultsThe overall response rate was 53% (74/140 participating units). All intensive care units had planned for capacity extensions;…
Small-x, Diffraction and Vector Mesons
2015
This talk discusses recent progress in some topics relevant for deep inelastic scattering at small x. We discuss first differences and similarities between conventional collinear factorization and the dipole picture of deep inelastic scattering. Many of the recent theoretical advances at small x are related to taking calculations in the nonlinear saturation regime to next-to-leading order accuracy in the QCD coupling. On the experimental side significant recent progress has been made in exclusive and diffractive processes, in particular in ultraperipheral nucleus-nucleus collisions.
Are the new genetic tools for diagnosis of Wilson disease helpful in clinical practice?
2020
Summary The diagnosis of Wilson disease is not always easy. For many patients, a combination of tests reflecting disturbed copper metabolism may be needed. Testing for ATP7B variants has become part of the routine diagnostic approach. The methods of genetic testing include analysis of the 21 coding exons and intronic flanking sequences, in which exons with recurrent variants would be prioritised depending on the mutation frequency in the local population. If sequencing the entire ATP7B gene cannot identify 2 variants and the suspicion for Wilson disease is high, after reviewing the clinical data, WES (whole-exome sequencing) or WGS (whole-genome sequencing) could be applied. A workflow base…
Fifth Generation Networking Principles for a Service Driven Future Internet Architecture
2010
Published version of an article published in Wireless Personal Communications, vol. 57:393-411. Also available from the publisher at: http://dx.doi.org/10.1007/s11277-010-0076-7 The vision of all-IP networks where IP forms the simple common layer understandable across the whole network has undeniable advantages. However, such simplicity comes as a major hurdle to flexibility and functionality to the architecture. This is evident from the increasingly numerous and complex engineering solutions and optimizations required to accommodate essential qualities like mobility, security, realtime communication support etc or to mitigate the shortcomings inherent in the 'traditional Internet' architec…
Large-scale compression of genomic sequence databases with the Burrows-Wheeler transform
2012
Motivation The Burrows-Wheeler transform (BWT) is the foundation of many algorithms for compression and indexing of text data, but the cost of computing the BWT of very large string collections has prevented these techniques from being widely applied to the large sets of sequences often encountered as the outcome of DNA sequencing experiments. In previous work, we presented a novel algorithm that allows the BWT of human genome scale data to be computed on very moderate hardware, thus enabling us to investigate the BWT as a tool for the compression of such datasets. Results We first used simulated reads to explore the relationship between the level of compression and the error rate, the leng…
Network and System Performance Management for Next Generation Networks
2006
The physical and logical structures of next generation network and service environment is complex and requires increasingly sophisticated and complicated tools to be fully controllable and well managed. The main problem that has risen is that the old telemanagement model has not enough flexibility to manage rapidly and constantly changing network environment. 3G and 4G networks are basically IP based and the knowledge of IP type traffic management is somewhat new and challenging to telecom vendors. The present way of controlling and managing telecom systems is to use Non Real Time off-line PM (Performance Monitoring) and tools. Time periods between tuning can now be some days to some weeks …
Zvaigžņotā Debess: 2011, Pavasaris (211)
2011
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Alksnis. XIV General Assembly of the International Astronomical Union (abridged) ; H.Strods. Jaunlaicene’s Watchmaker (abridged) ; I.Daube. At the Radioastrophysical Observatory of the Latvian Academy of Sciences (abridged). 50 YEARS SINCE GAGARIN’S SPACE FLIGHT: R.Misa. Dream about Cosmos ; A.Zalcmane. Konstantin Tsiolkovsky Astronautics Museum in Kaluga; E.Bērziņa. Outer Space in Pauls Stradins Museum of History of Medicine. NEWS: A.Alksnis. Different Faces of Whirpool Galaxy ; A.Alksnis. The Kleopatra’s Trio and other Minor Planets Groups. SPACE RESEARCH and EXPLORATION: V.Kalniņš. NASA Preparing Solar Probe Plus to Plunge into Sun's Atmos…
Next-Generation Sequencing: Application in Liver Cancer—Past, Present and Future?
2012
Hepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying pathobiological layers resulting in hepatocarcinogenesis. More recently, improvements of sophisticated next-generation sequencing (NGS) technologies have enabled complete and cost-efficient analyses of cancer genomes at a single nucleotide resolution and advanced into valuable tools in translational medicine. Although the use of NGS in human liver cancer is still in its infancy, great promise rests in the systematic integration of different …