Search results for "ngos"
showing 10 items of 115 documents
Solitary polypoid laryngeal xanthoma.
2013
We report the case of a 51-year-old male smoker with diabetes mellitus and hyperlipidaemia and a long history of human immunodeficiency virus (HIV)/hepatitis C virus (HCV) infection treated with various antiretroviral regimes, who was referred to the otolaryngology department with progressive dysphonia. Fibre-optic laryngoscopy showed a solitary, yellowish-white pedunculated polyp on the anterior third of the left cord, with no other abnormality. Pathological analysis revealed a polypoid laryngeal xanthoma that was immunoreactive against CD68, perilipin, and adipophilin. This unusual laryngeal lesion in the clinical context of our patient suggests a possible role of antiretroviral treatment…
Presencia de la langosta. Plagas en la Valencia bajomedieval
1997
La documentación municipal de Valencia es la base de este trabajo, en el que se precisa la cronología de las plagas de langosta que padecieron los campos del entorno de la ciudad en los siglos XIV y XV, y se analiza su incidencia en la vida urbana.
Adiciones y revisiones al Atlas de la flora vascular silvestre de Burgos, XI
2017
[ES] Se mencionan 38 táxones con citas y/o comentarios referidos a su existencia en la provincia de Burgos. De ellos, siete suponen una novedad para el catálogo provincial.
The Sphingosine Kinase-1 Activator, K6PC-5, Attenuates the Ebola Virus Infection and the Virus Induced Cell Death
2020
Ebola virus (EBOV) is responsible for outbreaks with case-fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths. EBOV glycoprotein (EBOV-GP) is the only viral surface protein and is responsible for viral entry into cells. It has been suggested to play a role in the cytopathic effects induced by the virus. Here we uncover a critical role for sphingolipids in inhibiting viral entry and virus-mediated cytotoxicity. Sphingosine kinase 1 (SphK1) catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). The administration of the SphK1 activator, K6PC-5, or S1P, or the overexpression of SphK1 consistently exhibited striking inhibito…
LASS6, an additional member of the longevity assurance gene family
2005
Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. In an effort to characterize additional members of the LAG family, we have screened the latest releases of genomic databases and report on the bioinformatic characterization of yet another member, LAG1 longevity assurance homolog 6 (LASS6). Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. In…
Reproductive outcomes after expectant and surgical management for tubal pregnancy: a retrospective study
2023
Background: The management of ectopic pregnancy is widely debated. Salpingectomy, salpingostomy, and expectant management are widely performed, but the best approach in terms of keeping good future spontaneous fertility chances is yet to be determined. Material and methods: We performed a retrospective analysis (Clinical Trial ID: NCT05479786) of the medical records of patients with an ultrasonographic or surgical diagnosis of tubal ectopic pregnancy that were admitted to the University of Debrecen Clinical Centre between 2012 and 2020. Results: A total of 312 patients were included in the analysis. Patients managed expectantly and patients treated with salpingostomy had significantly highe…
nCDase and SphK-1 localization in vesicles shed by tumour cells and their biological roles.
2007
Sphingolipid metabolism is a dynamic process resulting in the formation of a number of bioactive metabolites including ceramide, ceramide-1-phosphate, sphingosine e sphingosine-1-phosphate (S1P). (Pyne and Pyne; Biochem. J. 2000; 349:385-402). Following sphingomyelinase activation, sphingomyelin is hydrolyzed to ceramide, which is considered to be an inducer of cell growth arrest, differentiation and apoptosis. (Hannun et. al 1996; Science: 274:1855-1859). Ceramidase catalyzes the deacylation of ceramide to produce a free fatty acid and sphingosine. The enzyme sphingosine kinase (SphK) catalyzes the formation of S1P from sphingosine and ATP (Olivera et al. J.Biol.Chem. 1998; 273:12576- 1258…
Pratiche culturali e second welfare. Il ruolo del Terzo Settore nei processi di rigenerazione urbana nella città (post)pandemica
2022
In assenza di un sistema di welfare capace di rispondere alla crisi e al nuovo scenario che questa delinea, organizzazioni e pratiche culturali fanno fronte all’emergenza fornendo una risposta collettiva ai nuovi bisogni sociali e individuali. Con un forte radicamento territoriale, perseguono l’innovazione sociale attraverso l’empowerment delle comunità e dei contesti in cui operano, sperimentando nuovi modelli di governance e promuovendo un welfare locale in funzione degli spazi urbani e alla micro-scala urbana. A partire dalla mobilitazione sociale agita dagli attori del Terzo Settore culture-led, con un focus sul contesto palermitano, l’obiettivo di questo contributo è interrogarsi sul r…
NGOs and the implementation of active labour market policies : the case of Finland and Sweden
2012
Apuntes sobre la lucha contra la plaga de langosta en los escritos de los siglos modernos
2008
La inquietud suscitada por los efectos de las plagas de langosta, más allá del ámbito estrictamente campesino, históricamente ha transcendido a reyes, legistas, médicos o historiadores, que dejaron constancia de ella en sus obras o en la legislación. El presente estudio recopila información sobre el impacto que estas plagas causaron sobre todos los estamentos de la sociedad durante los siglos modernos. The concern about the effects of locust plagues, beyond the rural sphere, has historically transcended to kings, lawyers, doctors and historians, who have left evidence thereof in their works and legislation. The present study compiles together information on the impact of these pests in all …