Search results for "nitrile"
showing 10 items of 1539 documents
ChemInform Abstract: An Efficient Method for the Preparation of Antitumoral α-Keto-imines Benzyldihydroisoquinolines by Selective Benzylic Oxidation …
2010
A series of potent antitumor α-keto-imine BDHIQ derivatives were synthesized and assayed in vitro against L1210 leukemia cell line. A new and easy method for the direct formation of α-keto-imine from imine BDHIQ's was performed with 10% C/Pd in acetonitrile.
Antikonvulsiva,II. Die cyanethylierung im system des butyroguanamins
1987
Die die Anlagerung von Acrylnitril (2) beinhaltende Cyanethylierung des Butyroguanamins (1) fuhrt zu den cyanethylierten Propyl-1,3,5-triazinen 3, 4 und 5. Spektroskopisch auserst charakteristisch fur diese Strukturen ist in den IR-Spektren die scharfe Bande der C ≡ N-Valenzschwingung bei 2260 cm−1. Kennzeichnend in den Massenspektren ist die Abspaltung eines Cyanethylradikals. Wahrend 4 antikonvulsive und cytoprotektive Effekte auszulosen vermag, ist 5 Trager neuroleptischer und herbizider Wirksamkeit. The cyanoethylation of butyroguanamine (1) comprising the addition of acrylonitrile (2) leads to the cyanoethylated propyl-1,3,5-triazines 3, 4, and 5. The sharp band of the C ≡ N stretching…
ChemInform Abstract: Ru(bpy)2Cl2: A Catalyst Able to Shift the Course of the Photorearrangement in the Boulton-Katritzky Reaction.
2016
Abstract The Boulton–Katritzky reaction represents one of the most popular and efficient strategies used to realize azole-into-azole conversions. For example, under different experimental conditions, it allows the rearrangement of Z-arylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazoles (1) into 2-aryl-4-benzoylamino-5-phenyl-2H-1,2,3-triazoles (2) in very high yields. Moreover, we have recently realized this conversion also by UV-photostimulation. Now we have enlarged the scope of the reaction irradiating with visible or UV light an acetonitrile solution of some Z-arylhydrazones (1a–e) in the presence of catalytic amounts of Ru(bpy)2Cl2. We have observed the unexpected formation of the 1-a…
Determination of Homovanillic Acid in Human Plasma Using HPLC with Electrochemical Detection and Automated Solid Phase Extraction
1993
Abstract An isocratic HPLC method with electrochemical detection for the quantification of homovanillic acid (HVA) is described. The method included automated solid phase extraction on C-18-reversed phase material, followed by separation on a 3-μm Nucleosil 100 C18 column (250 mm × 4.6 mm I. D.) with a 100 mM citric acid solution (pH 6.6) containing 4% acetonitrile (v/v) as eluent at a flow rate of 0.6 ml/min. Isovanillinic acid served as internal standard. Extractability of both analytes was ca. 80 %. After extraction of 1 ml of plasma, coefficients of variation of replicate analyses were below 10 % in the naturally occuring concentration range.
Crystal Structures and Thermal Behavior of Bis(dibenzyldimethylammonium) Tetrabromometallates(II) [M = Mn(II), Co(II) and Zn(II)] and Their Solvates
2007
Six new A2MBr4 structures [A = dibenzyldimethylammonium cation,M = Mn(II), Co(II) or Zn(II)] were crystallized with or without solvent molecules from acetonitrile, methanol and/or aqueous solutions. The isomorphous compounds [(Bz2Me2N)2][MnBr4]·CH3CN·H2O (1) and [(Bz2Me2N)2]-[ZnBr4]·CH3CN·H2O (4) crystallize in the triclinic space group P1̄ from acetonitrile solutions. The solvent molecules participate in the hydrogen bonding network inside the crystal structure. [(Bz2Me2N)2][CoBr4]·0.5CH3CN (2) crystallizes from an acetonitrile solution in the monoclinic space group P21/c. The solvent molecules fill the voids of the crystal structure. Compound 2 is isostructural with the previously reporte…
Cyclocondensation of alpha-aminonitriles and enones: a short access to 3,4-dihydro-2H-pyrrole 2-carbonitriles and 2,3,5-trisubstituted pyrroles.
2009
The reaction of alpha,beta-unsaturated carbonyl compounds with aminoacetonitrile hydrochloride furnishes 3,5-disubstituted 3,4-dihydro-2H-pyrrole-2-carbonitriles in a one-pot reaction sequence. While these products can serve as starting materials for the preparation of polysubstituted pyrrolizidines, they are kinetically stable against the base-induced elimination of HCN. In contrast, their 2-substituted analogues obtained from alpha-substituted alpha-aminonitriles can be readily converted to the corresponding 2,3,5-trisubstituted pyrroles under microwave irradiation. The key step presumably involves the thermal electrocyclization of a stabilized 2-azapentadienyl anion formed by condensatio…
One-Pot Synthesis of (±)-Crispine A and Its C-Ring-Substituted Analogs
2006
A straightforward access to crispine A and C-ring-substituted analogs by 1,4-addition of a deprotonated α-amino nitrile to α,β-unsaturated carbonyl compounds is described. If the reduction step is omitted, substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines can be obtained. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
ChemInform Abstract: Cyclocondensation of α-Aminonitriles and Enones: A Short Access to 3,4-Dihydro-2H-pyrrole 2-Carbonitriles and 2,3,5-Trisubstitut…
2010
The reaction of α,β-unsaturated carbonyl compounds with aminoacetonitrile hydrochloride furnishes 3,5-disubstituted 3,4-dihydro-2H-pyrrole-2-carbonitriles in a one-pot reaction sequence. While these products can serve as starting materials for the preparation of polysubstituted pyrrolizidines, they are kinetically stable against the base-induced elimination of HCN. In contrast, their 2-substituted analogues obtained from α-substituted α-aminonitriles can be readily converted to the corresponding 2,3,5-trisubstituted pyrroles under microwave irradiation. The key step presumably involves the thermal electrocyclization of a stabilized 2-azapentadienyl anion formed by condensation of the reacta…
Photoinduced electron transfer in supramolecular complexes of a π-extended viologen with porphyrin monomer and dimer
2012
A π-extended viologen has been synthesized, forming supramolecular complexes with a freebase tetraphenylporphyrin (H2TPP) and the cofacial porphyrin dimer with an anthracene spacer [H4(DPA)] through π–π interaction in benzonitrile (PhCN). Formation of the H2TPP-BHV2+ supramolecular complex was probed by UV-vis and fluorescence spectra. The fluorescence of H2TPP was strongly quenched by electron transfer from the singlet excited state (1H2TPP*) to BHV2+ in the supramolecular complex. The transient absorption spectrum of the charge-separated (CS) state (H2TPP•+ and BHV•+) was successfully detected by the laser flash photolysis measurements of the H2TPP-BHV2+ supramolecular complex in PhCN. Th…
Redox properties of titanocene-pyrrole derivative and its electropolymerization
2001
A new titanocene dichloride derivative in which one cyclopentadienyl ligand (Cp) is functionalized with a pyrrolyl ring, Tc3Py (Cl2TiCpC5H4(CH2)3NC4H4), has been synthesized and characterized with NMR. Its redox properties have been studied by CV in acetonitrile (AN), tetrahydrofurane (THF) and dichloromethane (DCM), in comparison with unsubstituted titanocene dichloride (Tc) and pyrrole. Ti(IV/III) transition observed within the negative potential range is a quasi-reversible reaction in THF and DCM (but without a complete recuperation of the initial reagent in the back scan) while the reoxidation peak in AN is strongly shifted in the positive direction. These results are interpreted within…