Search results for "none"

showing 10 items of 1921 documents

Elimination kinetics of the novel prodrug cinazepam possessing psychotropic activity in mice.

2011

Abstract The kinetics of excretion of the novel tranquilizer cinazepam (3-hydroxy-7-bromo-5-( ortho -chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one hemisuccinate (I)) in mice after a single administration and different schemes of multiple administration were determined. Mass balance was studied daily in excretions of mice (feces and urine) for 5-10 days. We observed that monoexponen-tial renal excretion of 14 C-cinazepam and its metabolites predominated with all dosage regimens. Cinazepam and its metabolites were almost fully (> 90%) eliminated in urine and feces over the period of study (5-10 days), which means that no significant accumulation of the drug in the body occurred. The kin…

PharmacologyDrugBenzodiazepinonesmedicine.drug_classmedia_common.quotation_subjectGeneral MedicineUrinePharmacologyProdrugModels TheoreticalDrug Administration ScheduleExcretionchemistry.chemical_compoundMiceTranquilizerchemistryRenal physiologymedicineCinazepamAnimalsHypnotics and SedativesFemaleProdrugsXenobioticmedia_commonPharmacological reports : PR
researchProduct

Cytotoxicity of main anthraquinone aglycons towards drug sensitive and multi drug resistant T leukaemia cancer cells

2016

PharmacologyDrugChemistrymedia_common.quotation_subjectOrganic ChemistryPharmaceutical ScienceAnthraquinoneAnalytical Chemistrychemistry.chemical_compoundComplementary and alternative medicineDrug DiscoveryCancer cellCancer researchMolecular MedicineMulti drug resistantCytotoxicitymedia_commonPlanta Medica
researchProduct

Influence of Rhein on Rat Colonic Na<sup>+</sup>, K<sup>+</sup>-ATPase and Permeability in vitro

1988

Rhein, an aglucone of a laxative-acting anthraquinone, which induces net secretion in the human jejunum and colon, does not induce net secretion under open circuit current in in vitro conditions but r

PharmacologyGeneral MedicineAbsorption (skin)AnthraquinoneMolecular biologyIn vitroJejunumchemistry.chemical_compoundmedicine.anatomical_structureBiochemistrychemistryPermeability (electromagnetism)medicineAtpase activitySecretionNa+/K+-ATPasePharmacology
researchProduct

Optically active titanium complexes containing a tridentate linked amido-cyclopentadienyl ligand

2000

Optically active titanium complexes Ti{η5:η1-C5R4SiMe2NC6H10 (OCH2Ph)-2}Cl2 (R = H, Me), containing a cyclopentadienyl ligand linked to the chiral trans-2-benzyloxycyclohexylamido group, were synthesized and characterized in both enantiomerically pure forms. A single crystal X-ray structure analysis of (−)-(R,R)-Ti{η5:η1-C5H4SiMe2NC6H10(OCH2Ph)-2}Cl2 shows a structure in which the benzyloxy group in the amido sidechain is not interacting with the titanium center. Upon activation with n-butyllithium, these complexes hydrogenate acetophenone N-benzylimine with low enantioselectivity. Chirality 12:472–475, 2000. © 2000 Wiley-Liss, Inc.

PharmacologyLigandOrganic ChemistryCenter (category theory)chemistry.chemical_elementOptically activeCatalysisAnalytical Chemistrychemistry.chemical_compoundCrystallographychemistryCyclopentadienyl complexDrug DiscoveryOrganic chemistryChirality (chemistry)Single crystalSpectroscopyAcetophenoneTitaniumChirality
researchProduct

Evaluation of alprazolam-induced behavioural effects: differences with chlordiazepoxide after interaction with desipramine and rolipram, a cAMP phosp…

1989

PharmacologyMaleAlprazolamBehavior Animalbusiness.industryPhosphodiesterase InhibitorsDesipraminePhosphodiesteraseCAMP phosphodiesterase inhibitorChlordiazepoxideRats Inbred StrainsPharmacologyPyrrolidinonesChlordiazepoxideRatsAlprazolamDesipramineAnesthesiaMedicineAnimalsDrug InteractionsbusinessRolipramRoliprammedicine.drugPharmacological research
researchProduct

Head-twitch and forepaw-shake responses after single and repeated treatment with rolipram: interaction with noradrenergic and dopaminergic agonists a…

1988

PharmacologyMaleBehavior AnimalChemistryDopamine AgentsRats Inbred StrainsShakePharmacologyAutonomic AgentsPyrrolidinonesRatsRepeated treatmentForelimbmedicineHead (vessel)AnimalsDopamine AntagonistsDrug InteractionsDopaminergic AgonistsHeadRolipramRoliprammedicine.drugPharmacological research communications
researchProduct

Development of predictive retention-activity models of butyrophenones by biopartitioning micellar chromatography

2001

The predictive and interpretative capability of quantitative chromatographic retention-biological activity models is supported by the fact that in adequate experimental conditions the solute partitioning into the chromatographic system can emulate the solute partitioning into lipid bilayers of biological membranes, which is the basis of drug and metabolite uptake, passive transport across membranes and bioaccumulation. The use of retention data obtained in biopartitioning micellar chromatography (BMC) has been demonstrated to be helpful in describing the biological behaviour of different kinds of drugs. In this chromatographic system, polioxyethylene 23 lauryl ether Brij35 micellar mobile p…

PharmacologyNeuroleptic DrugsChromatographyPassive transportChemistryMetaboliteClinical BiochemistryBiological membraneGeneral MedicineBiochemistryMicelleAnalytical Chemistrychemistry.chemical_compoundMembraneStationary phaseDrug DiscoveryButyrophenonesMolecular BiologyBiomedical Chromatography
researchProduct

Quinol sulphate, a new conjugate of phenol in goldfish.

1983

1. Metabolism of phenol in goldfish yielded the known phenyl conjugates in fish--phenyl sulphate and phenyl glucuronide. Additionally, quinol sulphate, a new conjugate of phenol in fish, was detected.

PharmacologyPhenolChemistryHealth Toxicology and MutagenesisCyprinidaemacromolecular substancesGeneral MedicineMetabolismToxicologyBiochemistryHydroquinoneschemistry.chemical_compoundPhenolsGoldfishOrganic chemistryFish <Actinopterygii>PhenolAnimalssense organsChromatography Thin LayerGlucuronideChromatography High Pressure LiquidConjugateXenobiotica; the fate of foreign compounds in biological systems
researchProduct

Cardiovascular effects induced by rolipram, a selective cAMP phosphodiesterase inhibitor: Interaction with adrenergic and calcium affecting drugs

1990

PharmacologyPhosphodiesterase InhibitorsHemodynamicschemistry.chemical_elementAdrenergicCAMP phosphodiesterase inhibitorCalciumPharmacologyCalcium Channel BlockersPyrrolidinonesCalcium Channel Agonistschemistry3'5'-Cyclic-AMP PhosphodiesterasesmedicineAnimalsRabbitsSympathomimeticsRolipramRoliprammedicine.drugPharmacological Research
researchProduct

H2-antihistaminics. 20. Structure-activity relationships in H2-receptor antagonists containing a 4-pyrimidone moiety.

1984

In a series of 5,6-substituted 4- pyrimidones 1 a-v the H2-antihistaminic activity was determined (guinea-pig atrium) and lipophilicity data are given in form of Rmo -values. The influence of different substituents at position 5 or 6 of a pyrimidone moiety has been studied. Quantitative structure-activity analyses showed the importance of lipophilicity for drug activity. Additionally other physicochemical substituent-properties may play a major role.

PharmacologyStereochemistryImmunologyPharmacology toxicologyGuinea PigsHeartPyrimidinonesToxicologyLipidschemistry.chemical_compoundStructure-Activity RelationshipDrug activitychemistryHistamine H2 receptorHistamine H2 AntagonistsSolubilityLipophilicityMoietyAnimalsPharmacology (medical)PyrimidoneAgents and actions
researchProduct