Search results for "normalization"
showing 10 items of 632 documents
Strain induced renormalization of transport properties in UPt3 thin films
1996
The growth of sputter deposited UPt3 thin films on Al2O3 (1012), LaAlO3 (111) and SrTiO3 (111) was investigated. We found strongly 0001-textured growth of UPt3 in a small compositional range of 23–25% uranium content. For Al2O3-and LaAlO3-substrates no in-plane order could be observed whereas epitaxial growth was initiated on SrTiO3 (111): The growth can be identified as Vollmer-Weber like resulting in the formation of large lateral strain as a consequence of the growth mode and a lattice misfit of −4.3% between UPt3 (0001) and SrTiO3 (111). Strong deviations from the typical heavy-fermion characteristics in electronic transport properties like resistivity, magnetoresitivity and Hall-effect…
Multi-Path U-Net Architecture for Cell and Colony-Forming Unit Image Segmentation
2022
U-Net is the most cited and widely-used deep learning model for biomedical image segmentation. In this paper, we propose a new enhanced version of a ubiquitous U-Net architecture, which improves upon the original one in terms of generalization capabilities, while addressing several immanent shortcomings, such as constrained resolution and non-resilient receptive fields of the main pathway. Our novel multi-path architecture introduces a notion of an individual receptive field pathway, which is merged with other pathways at the bottom-most layer by concatenation and subsequent application of Layer Normalization and Spatial Dropout, which can improve generalization performance for small datase…
Adaptive control of a drilling system with unknown time-delay and disturbance
2016
In this paper, we address adaptive predictor feedback design for a simplified drilling system in the presence of disturbance and time-delay. The main objective is to stabilize the bottomhole pressure at a critical depth at a desired set-point directly. The stabilization of the dynamic system and the asymptotic tracking are demonstrated by the proposed adaptive control, where the adaptation employs Lyapunov update law design with normalization. The proposed method is evaluated using a high fidelity drilling simulator and cases from a North Sea drilling operation are simulated. The results show that the proposed predictor controller is effective to stabilize the bottom hole pressure within th…
Adaptive predictor control for stabilizing pressure in a managed pressure drilling system under time-delay
2016
Abstract In this paper, we address adaptive predictor feedback design for a simplified ODE drilling system in the presence of unknown parameter, disturbance and time-delay. The main objective is to stabilize the bottomhole pressure at a critical depth at a desired set-point directly. The time-delay in the transmission line of the drilling systems is considered. The stabilization of the dynamic system and the asymptotic tracking are demonstrated by the proposed predictor control, where the adaptation employs Lyapunov update law design with normalization. The proposed method is evaluated using a high fidelity drilling simulator and cases from a North Sea drilling operation are simulated. The …
Triplet 12B-12C-12N : Search for States with Halo
2020
Previously in [1] neutron halo was confirmed for the 2¯, 1.67 MeV and 1¯, 2.62 MeV states in 12B on base of Asymptotic Normalization Coefficients (ANC) method analysis of the obtained experimental data. An unexpected result was received for the unbound 3¯, 3.39 MeV state. Its halo radius was found to be increased and equal to ~5.9 fm. This result can be considered as an evidence of the halo-like structure in this 12B state. It should be noted that last neutron in this state has a non-zero orbital momentum (l = 2). So question arises about possible existence of states with halo in other members of the isobaric triplet 12B–12C–12N. We can expect the formation of a proton halo in the 2¯, 1.19 …
Removing Batch Effects from Longitudinal Gene Expression - Quantile Normalization Plus ComBat as Best Approach for Microarray Transcriptome Data
2016
International audience; Technical variation plays an important role in microarray-based gene expression studies, and batch effects explain a large proportion of this noise. It is therefore mandatory to eliminate technical variation while maintaining biological variability. Several strategies have been proposed for the removal of batch effects, although they have not been evaluated in large-scale longitudinal gene expression data. In this study, we aimed at identifying a suitable method for batch effect removal in a large study of microarray-based longitudinal gene expression. Monocytic gene expression was measured in 1092 participants of the Gutenberg Health Study at baseline and 5-year fol…
A standardization of the Novelty-Suppressed Feeding Test protocol in rats
2017
Tests based on hyponeophagia phenomena are the most widely used to check the efficacy and efficiency of new-generation chronic antidepressant treatments. Even so, these tests lack strict consensus about their methodology, which reduces their validity, reproducibility and makes translatability difficult. Therefore, after an extensive literature review on this subject, we propose a methodological protocol for the Novelty-Suppressed Feeding Test to normalize this situation. Animals were induced to a reserpine-induced depression model and were then chronically treated with duloxetine, desvenlafaxine or vehicle. After a 14-day treatment, a standardized Novelty-Suppressed Feeding Test was perform…
Normalization with Corresponding Naïve Tissue Minimizes Bias Caused by Commercial Reverse Transcription Kits on Quantitative Real-Time PCR Results
2016
Real-time reverse transcription polymerase chain reaction (PCR) is the gold standard for expression analysis. Designed to improve reproducibility and sensitivity, commercial kits are commonly used for the critical step of cDNA synthesis. The present study was designed to determine the impact of these kits. mRNA from mouse brains were pooled to create serial dilutions ranging from 0.0625 μg to 2 μg, which were transcribed into cDNA using four different commercial reverse-transcription kits. Next, we transcribed mRNA from brain tissue after acute brain injury and naïve mice into cDNA for qPCR. Depending on tested genes, some kits failed to show linear results in dilution series and revealed s…
Tales of healthy men: Male reproductive bodies in biomedicine from ‘Lebensborn’ to sperm banks
2012
Using the example of ‘sperm tales’, borne out of the biomedical technologies that went hand in hand with the establishment of the ‘science of man’ (andrology), the article engages with the epistemic evolution of interrelated biomedical theories and concepts of what constitutes a ‘healthy’ reproductive male body. The article asks: how has the normative ideal male body been either perpetuated or interrogated through these tales of male reproduction at the interface between scientific and medical technologies? And how were changes to the normalization of male bodies central to clinical practices and cultural understandings of health and illness? With many aspects of the medical history of male…
SPM-based count normalization provides excellent discrimination of mild Alzheimer's disease and amnestic mild cognitive impairment from healthy aging☆
2008
Statistical comparisons of [(18)F]FDG PET scans between healthy subjects and patients with Alzheimer's disease (AD) or amnestic mild cognitive impairment (aMCI) using Statistical Parametric Mapping (SPM) usually require normalization of regional tracer uptake via ROIs defined using additional software. Here, we validate a simple SPM-based method for count normalization. FDG PET scans of 21 mild, 15 very mild AD, 11 aMCI patients and 15 age-matched controls were analyzed. First, we obtained relative increases in the whole patient sample compared to controls (i.e. areas relatively preserved in patients) with proportional scaling to the cerebral global mean (CGM). Next, average absolute counts…