Search results for "noste"
showing 10 items of 18 documents
A Novel Series of Acylhydrazones as Potential Anti-Candida Agents: Design, Synthesis, Biological Evaluation and In Silico Studies
2019
In the context of an increased incidence of invasive fungal diseases, there is an imperative need of new antifungal drugs with improved activity and safety profiles. A novel series of acylhydrazones bearing a 1,4-phenylene-bisthiazole scaffold was designed based on an analysis of structures known to possess anti-Candida activity obtained from a literature review. Nine final compounds were synthesized and evaluated in vitro for their inhibitory activity against various strains of Candida spp. The anti-Candida activity assay revealed that some of the new compounds are as active as fluconazole against most of the tested strains. A molecular docking study was conducted in order to evaluate the …
Lanostanoids from fungi: a group of potential anticancer compounds.
2012
Lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have relevant biological and pharmacological properties, such as their cytotoxic effects via induction of apoptosis. This review compiles the most relevant lanostanoids studied from 2000 to 2011, principally those isolated from Ganoderma lucidum and other related fungi, such as Poria cocos, Laetiporus sulphureus, Inonotus obliquus, Antrodia camphorata, Daedalea dickinsii, and Elfvingia applanata, which have great potential as anticancer agents because of their cytotoxic or apoptotic effects. The compounds were selected on the basis of their proapoptotic mechanisms, through their ability to modify transcription…
ChemInform Abstract: Asymmetric Allylation/Pauson-Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid A…
2014
Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson–Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.
Transcriptome and metabolome analysis of citrus fruit to elucidate puffing disorder.
2014
a b s t r a c t A systems-level analysis reveals details of molecular mechanisms underlying puffing disorder in Citrus fruit. Flavedo, albedo and juice sac tissues of normal fruits and fruits displaying symptoms of puffing disorder were studied using metabolomics at three developmental stages. Microarrays were used to compare normal and puffed fruits for each of the three tissues. A protein-protein interaction network inferred from previous work on Arabidopsis identified hub proteins whose transcripts show significant changes in expression. Glycolysis, the backbone of primary metabolism, appeared to be severely affected by the disorder, based on both transcriptomic and metabolomic results. …
Newest Results on the Chemistry and Pharmacology of TCM Drugs Containing Triterpene and Steroid Saponins
2012
The aim of this review is to provide newest results in the chemistry, pharmacology, and clinical studies of saponins-containing TCM drugs, some of them being listed in the Chinese Pharmacopoeia. It appears that literature on triterpene saponins is more abundant than that of steroid saponins, and ginseng occupies a prominent position in the list. However, other TCM drugs are well documented in recent years belonging to the genera Astragalus, Gynostemma, Bupleurum, Clematis, Dipsacus, Platycodon, Gypsophila, Anemarrhena, Lonicera, Paris, Dioscerea, Tribulus, and Ophiopogon. From a Pharmacological point of view, the most relevant results have been obtained with the cancer-related activity and …
Isolierung und Identifizierung von Sterinen im Metabolismus des Pilzes Botrytis cinerea / Isolation and identification of sterols in the metabolism o…
1983
The fungus Botrytis cinerea, which belongs to the class of ascomycetes, has been analysed for its sterol composition. It is able to produce ergosterol, cerevisterol, lanosterol/dihydrolanosterol and cholesterol besides β-sitosterol. The identification of the sterols is carried out with different analytical methods including mass spectrometry. In the extracts of the mycelium also squalene has been identified
Über die Bildung von Cholesterin durch Botrytis cinerea nach Lanosterinzugabe / The Production of Cholesterol by Botrytis cinerea after Addition of L…
1980
Abstract The fungus Botrytis cinerea, which is found on the grapes, is able to produce cholesterol after addition of lanosterol to the culture medium. The identification of cholesterol is carried out with different analytical methods including mass spectrometry. Under the same conditions ergosterol arises from squalene and not cholesterol.
Wetting properties at the surface of iota-carrageenan-based edible films
2006
International audience; Surface properties of edible films composed of a polymeric matrix of carrageenan in association with hydrophobic material were studied by contact angle measurements. The use of this technique not only in a static mode but also in a dynamic way enables investigation of surface hydrophobicity as well as surface wettability. The absorption flux inside the material can be estimated from the wetting kinetic, which can be very useful to quickly compare water barrier efficiency of the tested films. Comparison of carrageenan films with films containing known amounts of additives enables understanding and correlation of changes of the surface properties with the nature of use…
Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disabilit…
2019
International audience; Purpose Lanosterol synthase (LSS) gene was initially described in families with extensive congenital cataracts. Recently, a study has highlighted LSS associated with hypotrichosis simplex. We expanded the phenotypic spectrum of LSS to a recessive neuroectodermal syndrome formerly named alopecia with mental retardation (APMR) syndrome. It is a rare autosomal recessive condition characterized by hypotrichosis and intellectual disability (ID) or developmental delay (DD), frequently associated with early-onset epilepsy and other dermatological features. Methods Through a multicenter international collaborative study, we identified LSS pathogenic variants in APMR individu…
Effect of surfactants and drying rate on barrier properties of emulsified edible films
2007
Summary The effects of globule size, nature and concentration of surfactant, and drying duration of water vapour transmission rate and tensile strength of emulsified edible barriers containing methylcellulose and paraffin wax, were measured. of the six surfactants tested, 0.6% purified glycerol monostearate (GMS) produced films with the lowest water vapour transmission rates and the highest mechanical resistance. Longer drying times of film-forming emulsions produced better barrier and mechanical properties. Control of the film forming emulsion stability allowed the reduction of the water vapour transfer rate by an order of magnitude.