Search results for "novel"
showing 10 items of 684 documents
P03-010-B - A novel mutation in MEFV gene is not enough
2013
Genotype-phenotype correlation is still challenging in FMF patients especially when the disease is part of a complex autoinflammatory disease.
Beyond Statins: New Lipid Lowering Strategies to Reduce Cardiovascular Risk
2014
Statins are the first-line therapy in LDL-Cholesterol (LDL-C) reduction and its clinical use has contributed to significant prevention and treatment of atherosclerotic vascular disease. Yet, a significant proportion of patients remain at high risk. Recently, a number of new therapies have been developed to further lower LDL-C. These agents may provide clinical benefit on top of statin therapy in patients with high residual risk, severe hypercholesterolemia or as an alternative for patients who are intolerant to statins. We review four novel approaches based on the inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein-B100 (apoB), Cholesteryl ester transport pro…
Early Mortality in Patients with Multiple Myeloma Treated with Novel Agents - Analysis from Polish Myeloma Study Group
2020
Background Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we evaluated the EM rate, and investigated the risk factors associated with EM in MM patients. Aims In this study we investigated risk factors associated with EM in MM patients initially treated with novel-agent containing regimen. Methods We conducted a multicenter (15 Polish sites) retrospective study a cohort of symptomatic MM pts diagnosed between October 2006 and November 2019 and living < 365 days (d) after diagnosis. All pts were dead at the time of the analysis. …
The Orienting Response in Healthy Aging: Novelty P3 Indicates No General Decline but Reduced Efficacy for Fast Stimulation Rates
2017
Automatic orienting to unexpected changes in the environment is a pre-requisite for adaptive behavior. One prominent mechanism of automatic attentional control is the Orienting Response (OR). Despite the fundamental significance of the OR in everyday life, only little is known about how the OR is affected by healthy aging. We tested this question in two age groups (19–38 years and 55–72 years) and measured skin-conductance responses (SCRs) and event-related brain potentials (ERPs) to novels (i.e., short environmental sounds presented only once in the experiment; 10% of the trials) compared to standard sounds (600 Hz sinusoidal tones with 200 ms duration; 90% of the trials). Novel and standa…
Kobiece poszukiwanie straconego czasu w powieści Tanji Stupar Trifunović "Satovi u majčinoj sobi"
2021
The aim of the article is to present a specifically female approach to memory in Tanja Stupar Trifunović’s novel Satovi u majćinoj sobi (Clocks in My Motherś Room). The novel is a kind of herstory; the Bosnian author reconstructed his own memory of the past after mothers death and initiated a female genealogy in her family this way. The form in which she manages to achieve this is an open mosaic novel. Full of ambivalence, home memory is a main element of the narrator’s identity, struggling with creative challenges and doubts because she is a writer. The story follows the rhythm of memory, the focus is on the mother-daughter and daughter-mother relationship, and the autobiographical memory …
Introduzione
2019
An introduction to Elsa de Giorgi's first novel
Imágenes posmodernas de la heroína siniestra: los referentes artísticos y su representación en la cultura popular
2021
En esta investigación hemos pretendido averiguar por qué en la cultura visual posmoderna occidental se multiplican imágenes e historias de un tipo de personaje femenino contradictorio y ambiguo, que hemos denominado como heroína siniestra. Una figura contradictoria en sí misma, pues comporta dentro de sí dos tipos de personajes que por definición son opuestos (la mujer siniestra y la heroína), por lo que hemos tenido que indagar primero en la construcción histórica, simbólica y cultural de los dos tipos de personajes de forma separada, para entender así sus características visuales y sus motivaciones psicológicas. Esta primera parte del estudio la planteamos de forma general, aunque analiza…
"Czytano je z zajęciem, a często ze wzruszeniem" : o zapomnianych powieściach Hanny Krzemienieckiej
2019
Janina née Bobińska Furs-Żyrkiewiczowa (1866–1930) is a forgotten author of works documenting the life of the Polish landed gentry and the intelligentsia in Russian Ukraine at the turn of the 19th and 20th centuries. Her three novels – Fatum. Studium psychologiczne (1904). A gdy odejdzie w przepaść wieczną… Romans zagrobowy (1906), Lecą wichry!( 1921) – in an interesting way they combine conventions of moral realism, decadent and lyrical atmosphere of modernism and the traditions of the “Ukrainian school” of Polish Romantic poetry (the writer was related to B. Zaleski). The prose of Krzemieniecka, the wife of a Pole and a high-ranking Russian officer, contains many autobiographical themes a…
Musical Feature and Novelty Curve Characterizations as Predictors of Segmentation Accuracy
2017
Novelty detection is a well-established method for analyzing the structure of music based on acoustic descriptors. Work on novelty-based segmentation prediction has mainly concentrated on enhancement of features and similarity matrices, novelty kernel computation and peak detection. Less attention, however, has been paid to characteristics of musical features and novelty curves, and their contribution to segmentation accuracy. This is particularly important as it can help unearth acoustic cues prompting perceptual segmentation and find new determinants of segmentation model performance. This study focused on spectral, rhythmic and harmonic prediction of perceptual segmentation density, whic…
From ‘Sedate' to ‘Rotten': the Role of Books in the Genesis of The Power and the Glory
2007
This paper traces the references to books in Greene's Journey Without Maps, The Lawless Roads and The Power and the Glory in order to map out the writer's journey to the origins of writing – counter to the priest's itinerary in the latter novel.