Search results for "nsaid"

showing 10 items of 14 documents

Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensiti…

2006

Background. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1*genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU).Methods. 69 patients with AICU, and 200 healthy subjects.Results. Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher…

AdultMaleSettore MED/09 - Medicina InternaChronic Idiopathic UrticariaGenotypeUrticariahuman leucocyte antigen class IImmunologyGenes MHC Class IIAnti-Inflammatory AgentsHuman leukocyte antigenLower riskDrug HypersensitivityResearch CommunicationAntigenGene FrequencyRisk FactorsGenotypelcsh:PathologyMedicineHumansAlleleAllele frequencyAllelesAspirinAspirinbusiness.industryAnti-Inflammatory Agents Non-SteroidalHistocompatibility Antigens Class ICase-control studyCell BiologyHLA-DR AntigensMiddle AgedNSAIDhuman leucocyte antigen class I; human leucocyte antigen class II; chronic idiopathic urticaria; aspirin; NSAIDs; hypersensitivityhuman leucocyte antigen class IIMHC Class IIPhenotypeGenesCase-Control StudiesImmunologyFemalehypersensitivityNon-Steroidalbusinesslcsh:RB1-214medicine.drugHLA-DRB1 ChainsMediators of Inflammation
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Analgesic effects of nonsteroidal anti-inflammatory drugs in cancer pain due to somatic or visceral mechanisms.

1999

The role of nonsteroidal anti-inflammatory drugs (NSAIDs) is well established in the treatment of cancer pain. This class of drugs is considered particularly effective in pain due to somatic mechanisms, although proof of this observation is lacking. To ascertain whether NSAIDs are more effective in specific nociceptive forms of cancer pain, they were administered alone or added to opioids in 32 patients with a sole pain mechanism, somatic pain due to bone metastases (17 patients) or visceral pain (15 patients), respectively. Pain intensity, mean doses of opioids used, and symptoms were recorded after starting NSAID. A significant reduction in pain intensity was found at 3, 7, and 14 days. N…

AdultMalemedicine.medical_specialtyPalliative careEpidemiologyAnalgesicPainOpioidAdverse effectPain ladderDiclofenacInternal medicineNeoplasmsMedicineHumansProspective StudiesCancer painAdverse effectNursing (all)2901 Nursing (miscellaneous)General NursingAgedAnalgesicsbusiness.industryAnti-Inflammatory Agents Non-SteroidalPalliative CareVisceral painMiddle AgedNSAIDVisceraAnesthesiology and Pain MedicineNeurologyOpioidAnesthesiaFemaleMechanismNeurology (clinical)medicine.symptombusinessCancer painmedicine.drugJournal of pain and symptom management
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Fatal hypersensitivity reaction to an oral spray of flurbiprofen: a case report

2013

Summary What is known and objective Safety of the anti-inflammatory drug flurbiprofen is comparable with that of other non-steroidal anti-inflammatory drugs of the propionic acid class, which are commonly associated with gastrointestinal and renal side effects. Here we report a case of a fatal hypersensitivity reaction to an oral spray of flurbiprofen taken for sore throat. Case summary A 29-year-old man came to the emergency care unit reporting sore throat with an intense burning sensation associated with fever. Pharyngotonsillitis was diagnosed, and local treatment with oral flurbiprofen spray was prescribed. Immediately after using the spray, the patient experienced a severe reaction cha…

AdultMaleoral sprayAllergyAdministration TopicalFlurbiprofenAdministration OralFatal hypersensitivity reaction; oral spray; flurbiprofenadverse Effect; adverse reaction; anti inflammatory; fatal reaction; flurbiprofen; hypersensitivity; NSAID; pharmacovigilance; sprayDrug HypersensitivitySettore MED/43 - Medicina LegalemedicineMaculopapular rashSore throatHumansPharmacology (medical)Fatal hypersensitivity reactionCause of deathPharmacologyAsphyxiabusiness.industryAnti-Inflammatory Agents Non-SteroidalPharyngitismusculoskeletal systemmedicine.diseaseflurbiprofenHypersensitivity reactionAnesthesiaItchinglipids (amino acids peptides and proteins)Oral Spraysmedicine.symptombusinessmedicine.drugJournal of Clinical Pharmacy and Therapeutics
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Safety of rofecoxib in subjects with a history of adverse cutaneous reactions to aspirin and/or non-steroidal anti-inflammatory drugs

2002

Background: Adverse reactions to non-steroidal anti-inflammatory drugs (NSAID)s are frequent, and the need to identify a safe alternative drug is a common problem in clinical practice. Objective: To assess the tolerability ofrofecoxib, a drug that specifically inhibits COX-2, in a group of NSAID-sensitive patients. Methods: One-hundred and four subjects (29 males and 75 females, mean age 35.6 ± 14.1) were enrolled. All subjects had experienced one or more episode characterized by cutaneous symptoms (erythema, and/or urticaria angioedema) following the assumption of NSAIDs; 92 subjects experienced reactions to only one NSAID (single intolerance: SI) and 12 subjects had reactions to multiple …

COX-lASAUrticariaAngioedema; ASA; COX; COX-2 inhibitors; COX-l; NSAID; Rofecoxib; Urticaria; ImmunologyImmunologyCOXAngioedemaCOX-2 inhibitorRofecoxibNSAID
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GASTROINTESTINAL COMPLICATIONS DURING USE OF ANTI-INFLAMMATORY DRUGS FOR ORTHOPEDIC DISEASES

2011

Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are molecules that inhibit the functionality of cyclooxygenase, resulting in suppression of prostaglandin production. Primary physicians and specialist clinics frequently prescribe NSAIDs for the treatment of osteoarticular diaseases such as tendinitis, bursitis, synovitis, spondylitis and osteoarthritis. This analysis aims to study gastrointestinal complications in orthopedic patients, caused by the use of NSAIDs, employng esophagogastroduodenoscopy and colonoscopy.

Gastrointestinal complications NSAIDs Gastritis Colitis.
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Diagnosis and therapeutic management of primary headache in an emergency setting

2013

Introduction and aim: Much headachers are under or mis-diagnoses and data regarding the proportion of patients attending an emergency department (ED) because of headache are still few. We conducted a retrospective observational study in an ED with the following aims: (a) estimate the proportion of headache attending to an ED (b) to estimate and describe the therapeutic management of primary headache and (c) to assessment the exam most frequently requested. Materials and methods: We collected data regarding patients diagnosed with headache consecutively attending the ED of the University of Palermo between September 2011 and March 2012. The study was approved by the ethics committee. Results: Between the semester evaluated 25110 subjects were admitted to ED headache suffers were equal to 1.6 %. Of these 263 (63.1 %) were woman and 154 (36.9 %). Mean age was 44.2 (DS ± 18.4) years (p = 0.068).According to ED registry headache admission was as follow assigned: 76.5 % with a diagnosis of headache 22.8 % with a secondary headache 0.7 % with Trigeminal Autonomic Cephalgias (TACs). Among those with a primary headache about 36 % of patient did not received a pharmacological treatment. Monotherapy was prescribed less frequently than combination therapy (19.1 vs 44.5 %).In monotherapy the most frequent medication were NSAIDs (28.3 %) benzodiazepines (26.7 %) and dopamine antagonists (11.7 %). Among those with a primary headache a CT scan was performed in the 124 subjects and 111 (34.8 %) had a neurologist consultation. Discussion: Our data are in line with the one previously reported in literature. The most frequently medication in the Italian ED were NSAIDs benzodiazepines dopamine antagonists and steroids. Neverless our data unlikely can be compared to other study give a snapshot. We believe that much more can be done to improve treatment of primary headache in ED.Settore MED/26 - Neurologia
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Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition …

2007

The molecular mechanisms behind the anti-neoplastic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are not completely understood and cannot be explained by the inhibition of the cyclooxygenase (COX) enzymes COX-1 and COX-2 alone. We previously reported that both the selective COX-1 inhibitor SC-560 and the selective COX-2 inhibitor CAY10404 exhibit anti-tumor effects in human hepatoma cells. NSAID inhibitors have many COX-independent actions and, among others, the mitogen-activated protein kinase (MAPK) pathways are targets for NSAIDs. Here, we examined the role of MEK/ERK1/2 signaling in the anti-neoplastic effects of both selective COX-1 and COX-2 inhibitors in two human hepato…

MAPK/ERK pathwayCancer ResearchCarcinoma HepatocellularTime FactorsBlotting WesternApoptosisPharmacologyCOX-1 COX-2 NSAIDs MEK1/2 ERK1/2NitrilesButadienesTumor Cells CulturedHumansCyclooxygenase InhibitorsSulfonesEnzyme InhibitorsPhosphorylationProtein kinase ACell ProliferationPharmacologychemistry.chemical_classificationMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase KinasesMitogen-Activated Protein Kinase 3biologyDose-Response Relationship DrugLiver NeoplasmsCytochromes cLong-term potentiationDrug SynergismIsoxazolesFlow CytometryEnzymeOncologychemistryCyclooxygenase 2CaspasesCancer cellbiology.proteinCyclooxygenase 1Molecular MedicineMEK-ERK PathwayPyrazolesDrug Therapy CombinationCyclooxygenaseHepatoma cellCancer biologytherapy
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Multiple actions of fenamates and other nonsteroidal anti-inflammatory drugs on GABAA receptors

2019

The nonsteroidal anti-inflammatory drug (NSAID) niflumic acid, a fenamate in structure, has many molecular targets, one of them being specific subtypes of the main inhibitory ligand-gated anion channel, the GABA(A) receptor. Here, we report on the effects of other fenamates and other classes of NSAIDs on brain picrotoxinin-sensitive GABA A receptors, using an autoradiographic assay with [S-35]TBPS as a ligand on mouse brain sections. We found that the other fenamates studied (flufenamic acid, meclofenamic acid, mefenamic acid and tolfenamic acid) affected the autoradiographic signal at low micromolar concentrations in a facilitatory-like allosteric fashion, i.e., without having affinity to …

MECHANISM0301 basic medicineNSAID drugsMefenamic acidAllosteric regulationPharmacologyBINDING-SITESGABA03 medical and health sciences0302 clinical medicineTolfenamic acidNiflumic acidmedicineSHIFTMODULATIONReceptorXenopus oocytesAGENTPharmacologyChemistryGABAA receptorNiflumic acidANION GRADIENTA RECEPTORSSUBUNITS3. Good healthMeclofenamic acidFenamates030104 developmental biologyFlufenamic acid317 PharmacyACIDAutoradiography030217 neurology & neurosurgeryRecombinant GABA(A) receptorsRESPONSESmedicine.drugEuropean Journal of Pharmacology
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A randomised controlled study on the use of anti-inflammatory drugs in patients with cancer pain on morphine therapy: effects on dose-escalation and …

2002

The role of non-steroidal anti-inflammatory drugs (NSAIDs) in cancer pain has been well established in the treatment of mild pain and in association with opioids in the treatment of moderate to severe pain. The aim of this study was to verify the effects of NSAIDs on morphine escalation in advanced cancer patients with pain followed-up at home and to assess the pharmacoeconomic implications. A prospective randomised controlled study was carried out in 156 consecutive advanced cancer patients with pain followed-up at home in the period December 1999-December 2000. In this group of patients, 47 were selected with pain progression after 1 week of opioid stabilisation. Patients were randomly as…

MaleCancer ResearchPainHome careDose-escalationNeoplasmsHumansProspective StudiesCancer painAgedRandomised controlled studyAnalysis of VarianceDose-Response Relationship DrugMorphineAnti-Inflammatory Agents Non-SteroidalPalliative CareHematologyPharmacoeconomic analysiMiddle AgedAdvanced cancer patientNSAIDAnalgesics OpioidOncologyDrug Therapy CombinationFemaleFollow-Up StudiesEuropean journal of cancer (Oxford, England : 1990)
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Prostaglandin E2 receptors and COX enxymes in human hepatocellular carcinoma: role in the regulation of cell growth

2008

The aim of this study was to investigate the expression of prostaglandin E 2 receptors (EP 1-4 ), cyclooxygenase-1 (COX-1), and COX-2 in nontumor and tumor human liver tissues, and also to evaluate the antitumor activity of selective EP 1 receptor antagonist used alone or in combination with COX-1 and COX-2 selective inhibitors. Semiquantitative PCR analyses revealed that EP 1-4 , COX-1, and COX-2 mRNA expression was detected in nearly all the tissue samples assayed, although with a high variability between nontumor and tumor tissues. In vitro EP 1 receptor antagonist inhibited anchorage-independent cell growth and reduced the viability of hepatocellular carcinoma (HCC) cells in a dose-depe…

Malemedicine.medical_specialtyEP receptorSettore MED/09 - Medicina InternaCarcinoma Hepatocellularmedicine.drug_classProstaglandinmedicine.medical_treatmentGeneral Biochemistry Genetics and Molecular Biologyhepatocellular carcinoma (HCC)History and Philosophy of ScienceInternal medicineCell Line Tumormedicinecell growthHumansReceptors Prostaglandin EProstaglandin E2ReceptorAgedCOX-1ChemistryCell growthGeneral NeuroscienceLiver NeoplasmsCOX-2Middle Agedmedicine.diseaseReceptor antagonistNSAIDIn vitroCyclooxygenaseEndocrinologyProstaglandin-Endoperoxide SynthasesHepatocellular carcinomaSettore BIO/14 - FarmacologiaCancer researchFemaleLiver cancerCell DivisionProstaglandin Emedicine.drug
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