Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity

6533b7d1fe1ef96bd125cd3f

RESEARCH PRODUCT

Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity

Nicola Martinelli Gaetana Di Fede Giovam Battista Rini Maria Esposito-pellitteri Pasquale Mansueto Roberto Corrocher Maria Luisa Pacor P. Pradella Laura Uxa Gabriele Di Lorenzo

subject

Adult Male Settore MED/09 - Medicina Interna Chronic Idiopathic Urticaria Genotype Urticaria human leucocyte antigen class I Immunology Genes MHC Class II Anti-Inflammatory Agents Human leukocyte antigen Lower risk Drug Hypersensitivity Research Communication Antigen Gene Frequency Risk Factors Genotype lcsh:Pathology Medicine Humans Allele Allele frequency Alleles Aspirin Aspirin business.industry Anti-Inflammatory Agents Non-Steroidal Histocompatibility Antigens Class I Case-control study Cell Biology HLA-DR Antigens Middle Aged NSAID human leucocyte antigen class I; human leucocyte antigen class II; chronic idiopathic urticaria; aspirin; NSAIDs; hypersensitivity human leucocyte antigen class II MHC Class II Phenotype Genes Case-Control Studies Immunology Female hypersensitivity Non-Steroidal business lcsh:RB1-214 medicine.drug HLA-DRB1 Chains

description

Background. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1*genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU).Methods. 69 patients with AICU, and 200 healthy subjects.Results. Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences were found between patients and controls as regards to HLA-DRB1*genotype.Conclusions. We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first description of such association.

year	journal	country	edition	language
2006-10-01	Mediators of Inflammation

10.1155/mi/2006/62489 http://europepmc.org/articles/PMC1657079