0000000000149639

AUTHOR

P. Pradella

showing 1 related works from this author

Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensiti…

2006

Background. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1*genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU).Methods. 69 patients with AICU, and 200 healthy subjects.Results. Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher…

AdultMaleSettore MED/09 - Medicina InternaChronic Idiopathic UrticariaGenotypeUrticariahuman leucocyte antigen class IImmunologyGenes MHC Class IIAnti-Inflammatory AgentsHuman leukocyte antigenLower riskDrug HypersensitivityResearch CommunicationAntigenGene FrequencyRisk FactorsGenotypelcsh:PathologyMedicineHumansAlleleAllele frequencyAllelesAspirinAspirinbusiness.industryAnti-Inflammatory Agents Non-SteroidalHistocompatibility Antigens Class ICase-control studyCell BiologyHLA-DR AntigensMiddle AgedNSAIDhuman leucocyte antigen class I; human leucocyte antigen class II; chronic idiopathic urticaria; aspirin; NSAIDs; hypersensitivityhuman leucocyte antigen class IIMHC Class IIPhenotypeGenesCase-Control StudiesImmunologyFemalehypersensitivityNon-Steroidalbusinesslcsh:RB1-214medicine.drugHLA-DRB1 ChainsMediators of Inflammation
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