Search results for "observation"
showing 10 items of 1586 documents
FILTERING CHAOS: A TECHNIQUE TO ESTIMATE DYNAMICAL AND OBSERVATIONAL NOISE IN NONLINEAR SYSTEMS
2005
Nonlinear dynamical models are frequently used to approximate and predict observed physical, biological and economic systems. Such models will be subject to errors both in the model dynamics, and the observations of the underlying system. In order to improve models, it is necessary to understand the causes of error growth. A complication with chaotic models is that small errors may be amplified by the model dynamics. This paper proposes a technique for estimating levels of both dynamical and observational noise, based on the model drift. The method is demonstrated for a number of models, for cases with both stochastic and nonstochastic dynamical errors. The effect of smoothing or treating …
2 years in the life of COPD patients: Evolution of GOLD 2011 classification in the 'real-life' DACCORD study
2016
Introduction Limited data are available on the progression of COPD categorised according to GOLD 2011. We analysed data from the ongoing, non-interventional, observational DACCORD study and compared baseline GOLD 2011 categorisation with that of 1 and 2-years after inclusion. Methods Patients with a diagnosis of COPD were recruited into DACCORD following either a change or initiation of maintenance medication. Baseline exacerbations data (collected over 6 months) were annualised for GOLD categorisation at baseline; COPD symptoms were evaluated using the COPD Assessment Test (CAT) at baseline as well as the 1 year and 2 year visit. Data on exacerbations were collected every 3 months up to 2 …
Late Breaking Abstract - Validation of a tool for the assessment of disease awareness (DA) in COPD
2017
Background: DA could influence adherence to treatment and outcomes. No validated tools are available to assess DA in COPD Aims: To generate a tool able to explore DA in COPD patients, the Disease Awareness in COPD Questionnaire (DACQ) Methods: A 2-step Delphi approach was used to develop a questionnaire that was tested for validity in a cohort of COPD patients of an Italian observational, multicenter, prospective study (SAT study - NCT02689492) Results: Consensus on a 27-item provisional questionnaire was obtained with 2 Delphi rounds. Factor analysis showed a 4-factor solution accounting for 35% of variance; each factor (disease acceptance, awareness of treatment needs, disease knowledge, …
Switch from LABA+ICS to a LABA/LAMA combination in symptomatic women with COPD – an analysis of the observational DACCORD study
2018
Introduction: COPD prevalence in women has increased in recent years and the importance of avoiding ICS use in this group, because of its potential negative impact on comorbidities such as osteoporosis and diabetes, has become a topic of interest. In this real-life cohort women with COPD that were switched from LABA+ICS treatment to a fixed combination of LABA/LAMA were followed for 1 year. Methods: DACCORD is a prospective, non-interventional 2-year study in the primary and secondary care setting throughout Germany. Patients were recruited after a change in, or initiation of COPD maintenance medication. Data collected at baseline and every 3 months included moderate/severe exacerbations an…
Dual bronchodilation vs triple therapy in the “real-life” COPD DACCORD study
2018
Roland Buhl,1 Carl-Peter Criée,2 Peter Kardos,3 Claus F Vogelmeier,4 Konstantinos Kostikas,5 Nadine S Lossi,6 Heinrich Worth7 1Pulmonary Department, Mainz University Hospital, Mainz, 2Department of Sleep and Respiratory Medicine, Evangelical Hospital Goettingen-Weende, Bovenden, 3Group Practice and Centre for Allergy, Respiratory and Sleep Medicine, Red Cross Maingau Hospital, Frankfurt am Main, 4Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany; 5WorldWide Medical Affairs Respiratory, Novartis Pharma AG, Basel, Switzerland;…
CODEX Weak Lensing Mass Catalogue and implications on the mass-richness relation
2021
The COnstrain Dark Energy with X-ray clusters (CODEX) sample contains the largest flux limited sample of X-ray clusters at $0.35 = \alpha \mu + \beta$, with $\mu = \ln (M_{200c}/M_{\mathrm{piv}})$, and $M_{\mathrm{piv}} = 10^{14.81} M_{\odot}$. We find a slope $\alpha = 0.49^{+0.20}_{-0.15}$, normalization $ \exp(\beta) = 84.0^{+9.2}_{-14.8}$ and $\sigma_{\ln \lambda | \mu} = 0.17^{+0.13}_{-0.09}$ using CFHT richness estimates. In comparison to other weak lensing richness-mass relations, we find the normalization of the richness statistically agreeing with the normalization of other scaling relations from a broad redshift range ($0.0<z<0.65$) and with different cluster selection (X-ray, Sun…
Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study.
2021
Abstract Background and aims Central and Eastern Europe (CEE) is a largely understudied region, despite having the highest cardiovascular disease mortality in Europe. This analysis aimed to assess the proportion of patients in CEE who achieved their LDL-C goals based on individual cardiovascular risk recommended by the 2016 and 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines. Methods The DA VINCI study was a cross-sectional observational study of primary and secondary prevention patients receiving lipid-lowering therapy across Europe between June 2017 and November 2018. Results In total, 2154 patients were enrolled from the Czech Republic (n = 509…
Improved limit on the directly measured antiproton lifetime
2017
Continuous monitoring of a cloud of antiprotons stored in a Penning trap for 405 days enables us to set an improved limit on the directly measured antiproton lifetime. From our measurements we extract a storage time of $3.15\times {10}^{8}$ equivalent antiproton-seconds, resulting in a lower lifetime limit of ${\tau }_{\bar{{\rm{p}}}}\gt 10.2\,{\rm{a}}$ with a confidence level of $68 \% $. This result improves the limit on charge-parity-time violation in antiproton decays based on direct observation by a factor of 7.
Observations of molecular hydrogen (H2) mixing ratio and stable isotopic composition (deuterium content) at the Cabauw tall tower in the Netherlands
2016
This zip file contains the final corrected data that were used for the journal article "Observations of molecular hydrogen mixing ratio and stable isotopic composition at the Cabauw tall tower in the Netherlands" by Batenburg et al., Atmospheric Environment, 2016, doi:10.1016/j.atmosenv.2016.09.058 Please cite the original AtmosEnv article when using these data. The paper also contains more information about how these data were collected and calibrated, and on how the quality control flags were assigned. All samples were collected at the Cabauw tower, at the CESAR site (51.971° N, 4.927° E, http://www.cesar-observatory.nl/). H2 and deltaD(H2) are calibrated using one to four laboratory re…
Factors Associated with Prolonged Patient-Attributable Delay in the Diagnosis of Colorectal Cancer
2018
Purpose The delayed diagnosis of colorectal cancer (CRC) may be attributable to sociodemographic characteristics, to aspects of tumour histopathology or to the functioning of the health system. We seek to determine which of these factors most influences prolonged patient-attributable delay (PPAD) in the diagnosis and treatment of CRC. Materials and methods A prospective, multicentre observational study was conducted in 22 Spanish hospitals. In total, 1,785 patients were recruited to the study between 2010 and 2012 and underwent elective or urgent surgery. PPAD is considered to occur when the time elapsed between a patient presenting the symptom and him/her seeking attention from the primary…