Search results for "odio"
showing 10 items of 258 documents
Hepatoprotective Effect of Steroidal Glycosides From Dioscorea villosa on Hydrogen Peroxide-Induced Hepatotoxicity in HepG2 Cells
2018
Dioscorea villosa, commonly known as “Wild Yam” and native to North America, is well documented for its pharmacological properties due to the presence of steroidal glycosides. However, the hepatoprotective potential of these compounds has not been studied so far. The present investigation was aimed to study the hepatoprotective effect of the steroidal glycosides from D. villosa against H2O2, a known hepatotoxin, in human liver cell line (HepG2). Cytotoxicity assessment was carried out in cells exposed to various concentrations (10–50 μM) of compounds for 24 h using MTT assay and morphological changes. All tested compounds were known and among them, spirostans (zingiberensis saponin I, diosc…
Energy transduction and signal averaging of fluctuating electric fields by a single protein ion channel
2016
[EN] We demonstrate the electrical rectification and signal averaging of fluctuating signals using a biological nanostructure in aqueous solution: a single protein ion channel inserted in the lipid bilayer characteristic of cell membranes. The conversion of oscillating, zero time-average potentials into directional currents permits charging of a load capacitor to significant steady-state voltages within a few minutes in the case of the outer membrane porin F (OmpF) protein, a bacterial channel of Escherichia coli. The experiments and simulations show signal averaging effects at a more fundamental level than the traditional cell and tissue scales, which are characterized by ensembles of many…
Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems.
2017
Background 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of toxicity is highly dependent on the aryl hydrocarbon receptor (AHR). Binding of TCDD to the AHR leads to changes in transcription of numerous genes. Studies evaluating the transcriptional changes brought on by TCDD may provide valuable insight into the role of the AHR in human health and disease. We therefore compiled a collection of transcriptomic datasets that can be used to aid the scientific community in better understanding the transcriptiona…
Immunmodulatory and Antiproliferative Properties of Rhodiola Species.
2016
The traditional medicines of Asia and Europe have long used various Rhodiola species, which are endemic to the subarctic areas of the northern hemisphere, as tonic, adaptogen, antidepressant, and anti-inflammatory drugs. In order to establish the therapeutic uses of these plants in modern medicine, the pharmacological effects of Rhodiola sp. have been widely studied. Indeed, the most amply researched species, Rhodiola rosea, has been shown to possess antioxidant, adaptogenic, antistress, antimicrobial, immunomodulatory, angiomodulatory, and antitumoral effects. Salidroside (p-hydroxyphenethyl-β-D-glucoside), a major compound in Rhodiola, seems to be responsible for many of the effects obser…
CCDC 1816139: Experimental Crystal Structure Determination
2018
Related Article: Aysun Çapcı Karagöz, Christoph Reiter, Ean-Jeong Seo, Lisa Gruber, Friedrich Hahn, Maria Leidenberger, Volker Klein, Frank Hampel, Oliver Friedrich, Manfred Marschall, Barbara Kappes, Thomas Efferth, Svetlana B. Tsogoeva|2018|Bioorg.Med.Chem.|26|3610|doi:10.1016/j.bmc.2018.05.041
Sobre la vegetación de la alianza Homalothecio-Polypodion serrati en las montañas valencianas
1983
Se han estudiado las comunidades de la alianza Homalothecio-Polypodion serrati en las montañas de la región valenciana y alrededores, encontrándose que las mismas pueden atribuirse a cuatro asociaciones: Anomodonio-Polypodietum serrati, Saxifragetum cossonianae, Saxifragetum latepetiolatae y Homalothecio-Asplenietum fontani. Se presentan sendas tablas fitosociológicas de cada una de las tres últimas, de las cuales se comentan, asimismo, sus principales notas características. The communities included in the alliance Homalothecio-Polypodio serrati are studied in Valencia region and neighbouring areas. 4 associations can be assigned to them: Anomodonio-Polypodietum serrati, Saxifragetum cosson…
El derecho a la libertad de expresión y su relación con el discurso del odio: estándares internacionales de protección y su reflejo en el ordenamient…
2015
El presente proyecto de tesis doctoral tiene como objetivo principal la investigación de la relación entre el derecho a la libertad de expresión y el conocido como discurso del odio, en el marco del ordenamiento jurídico español. Este trabajo se realiza con la finalidad de identificar qué mecanismos legales se han previsto para abordar estas situaciones, y si la respuesta que se ha configurado está en consonancia con las obligaciones contraídas por España en el ámbito internacional en esta materia. Para ello es imprescindible el estudio de la interpretación jurisprudencial de esta normativa para conocer la existencia de posibles disfunciones entre estos tres ámbitos. Los problemas actuales …
Criterios de selección y caracterización de episodios de lluvia. Aplicación a la Confederación Hidrográfica del Júcar (1989-2003)
2006
El análisis espacio-temporal de la lluvia precisa de la identificación de episodios, en función del objetivo de la investigación y la escala de trabajo. En esta comunicación se proponen criterios de selección de episodios, con objetivos hidrológicos, y se aplican al territorio de la Confederación Hidrográfica del Júcar, en base a los datos diarios de 15 años (1989-2003), proporcionados por el Sistema Automático de Información Hidrológica. Se seleccionan 363 episodios y se caracterizan en base a indicadores de total, duración, intensidad e irregularidad, calculados en once unidades territoriales. El análisis de estos indicadores evidencia una dicotomía litoral-interior. El ámbito litoral (ex…
Calibration of the photon spectrometer PHOS of the ALICE experiment
2019
Journal of Instrumentation 14(05), P05025 - P05025 (2019). doi:10.1088/1748-0221/14/05/P05025
Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan : what …
2019
Albuminuria; Atrasentan; Canagliflozin Albuminuria; Atrasentan; Canagliflozina Albuminúria; Atrasentan; Canagliflozina In April 2019, two major Phase 3 randomized clinical trials were published that assessed primary renal outcomes in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) tested an already available antidiabetic drug, canagliflozin, and the Study of Diabetic Nephropathy with Atrasentan (SONAR) tested a novel molecule, the endothelin-1 receptor blocker atrasentan, both on top of renin-angiotensin system blockade. Both trials demonstrated significant nephroprot…