Search results for "oie"
showing 10 items of 1669 documents
La mitopoiesi di Colapesce: metafora medievale del siciliano mezzo-uomo e mezzo-pesce
2008
Kìnesis e akinesìa, movimento e privazione dello stesso, queste le azioni da cui prende forma il racconto medievale di Colapesce. E Colapesce è il re mezzo-uomo e mezzo-pesce che governa il limen sottile e labile tra terra e acqua, perennemente in bilico, come è in fondo la condizione di tutti i siciliani, così radicati alla terra e così tendenti alla grandezza del mare. Ma la terra alla quale sono radicati è circondata dall’acqua, è una terra che costringe ad attraversare l’acqua per raggiugere altra terra nuova e diversa. Attraverso un excursus che va dalle origini del mito - dalla nascita in Puglia, alla ben più nota narrazione che ne fa il Pitré - , fino all’analisi dell’impianto del ra…
Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myoki…
2021
Extracellular vesicles (EVs) have emerged as key players of intercellular communication and mediate crosstalk between tissues. Metastatic tumors release tumorigenic EVs, capable of pre-conditioning distal sites for organotropic metastasis. Growing evidence identifies muscle cell-derived EVs and myokines as potent mediators of cellular differentiation, proliferation, and metabolism. Muscle-derived EVs cargo myokines and other biological modulators like microRNAs, cytokines, chemokines, and prostaglandins hence, are likely to modulate the remodeling of niches in vital sites, such as liver and adipose tissues. Despite the scarcity of evidence to support a direct relationship between muscle-EVs…
Treatment of Knee Osteoarthritis with Bone Marrow-Derived Mononuclear Cell Injection: 12-Month Follow-up.
2018
Objectives To evaluate the main symptoms of knee osteoarthritis (OA) and tissue structure changes after a single dose bone marrow–derived mononuclear cell (BM MNC) intra articular injection. Case series study. Patients with knee OA Kellgren Lawrence (K-L) grade II and III received 1 injection of BM MNC. The clinical results were analyzed with the Knee injury and Osteoarthritis Outcome Score (KOOS) and Knee Society Score (KSS) before, 3, 6, and 12 months after injection. Radiological evaluation was performed with a calibrated x-ray and the magnetic resonance (MR) imaging before and 6 to 7 months postinjection. Results A total of 34 knees were treated with BM MNC injections. Mean (±SD) age of…
Chromogenic detection of nerve agent mimics
2008
The current rise in international concern over criminal terrorist attacks via chemical warfare (CW) agents has resulted in an increasing interest in the detection of these lethal chemicals. Among CW species, nerve agents are extremely dangerous and their high toxicity and ease of production underscore the need to detect these deadly chemicals via quick and reliable procedures. A number of detection systems have been developed, most of them based on enzymatic and physical methodologies. However, these usually show limitations such as low selectivity, lack of portability and a certain complexity in their use. An alternative to these classical methods that has been gaining interest in recent y…
Role of PRRs (TLR2 and Dectin-1) in hematopoietic stem and progenitor cell differentiation: implications in protection against Candida albicans infec…
2020
Detection of infection by hematopoietic stem and progenitor cells (HSPCs) is essential to replace myeloid cells consumed during the immune response. HSPCs express some functional pattern recognition receptors involved in the recognition of Candida albicans. In this context, our group has previously demonstrated that C. albicans yeasts induce proliferation and differentiation of HSPCs via TLR2 and Dectin-1. In the present PhD thesis, we used in vitro and ex vivo models of HSPC differentiation to investigate the functional consequences for mature myeloid cells of exposure of HSPCs to PAMPs or C. albicans yeasts. In vitro experiments show that murine HSPCs continuously exposed to TLR2 or TLR4 …
Mārketinga komunikācijas analīze uzņēmumā "BBfactory"
2021
Bakalaura darba tēma ir - Mārketinga komunikācijas analīze uzņēmumā “BBfactory”. Bakalaura darba mērķis - pamatojoties uz mārketinga teorētiskās informācijas analīzi, autoru viedokļiem; aktuālajām mārketinga komunikāciju tendencēm, kā arī dabīgās kosmētikas aktualitāti mūsdienās, analizēt mārketinga komunikācijas pasākumus uzņēmumā “Bbfactory” un identificēt mārketinga komunikāciju nepilnības, un izvirzīt priekšlikumus to pilnveidošanai. Bakalaura darbs sastāv no trīs nodaļām, kā arī ievada, secinājumiem, priekšlikumiem, izmantotā literatūras saraksta un pielikumiem. Pirmajā nodaļā tiek apkopoti teorētiskie aspekti par komunikācijas procesu un mārketinga komunikācijas būtību, kā arī par mār…
Perorāli ievadīta metformīna ietekme uz neiroiekaisumu un smadzeņu neironālo plasticitāti Alcheimera slimības tipa modeļa žurkās
2019
Alcheimera slimība (AD) ir pasaulē visbiežāk sastopamā neirodeģeneratīvā saslimšana, kā arī biežākais demences izraisītājs, turklāt šīs slimības izplatība ar katru gadu pieaug. Līdz šim izmantota simptomātiska terapija un kopš 2003. gada nav apstiprināts neviens jauns medikaments AD ārstēšanai, tādēļ arvien tiek meklēti jauni terapijas virzieni (Hung and Fu, 2017). Ņemot vērā, ka AD pacientu smadzenēs novērojami glikozes metabolisma traucējumi un paaugstināts cerebrālais glikozes līmenis (Campbell et al., 2017), mēs pārbaudījām antidiabētiskā preparāta metformīna devu (75 mg/kg un 100 mg/kg) ietekmi uz neiroieksumu un neironālo plasticitāti streptozocīna (STZ) izraisītāAD tipa modeļa žurkās…
Analysis of structural plasticity in the adult and adolescent mouse brain. Effects of erythropoietin
2019
INTRODUCCIÓN Los organismos están sujetos diariamente a cambios que ocurren en su entorno y dentro del propio organismo. Estas entradas de información del medio externo e interno son integradas y analizadas por el organismo con el fin de dar una respuesta adecuada que asegure la supervivencia. Es crucial, por lo tanto, que el sistema responda de forma apropiada al amplio abanico de cambios y demandas que acontecen a lo largo de la vida del organismo. En este aspecto, el sistema nervioso se destaca como uno de los principales sistemas encargados de mantener el orden interno y reaccionar con cambios adaptativos a los eventos que lo rodean. Un funcionamiento aberrante del sistema da lugar a la…
New simple hydrophobic proline derivatives as highly active and stereoselective catalysts for the direct asymmetric aldol reaction in aqueous medium
2008
New 4-substituted acyloxyproline derivatives with different hydrophobic properties of the acyl group were easily synthesized and used as catalysts in the direct asymmetric aldol reaction between cyclic ketones (cyclohexanone and cyclopentanone) and several substituted benzaldehydes. Reactions were carried out using water, this being the best reaction medium examined. Screening of these catalysts showed that compounds bearing the most hydrophobic acyl chains [4-phenylbutanoate and 4-(pyren-1-yl)butanoate] provided better results. The latter catalysts were successfully used in only 2 mol% at room temperature without additives to give aldol products in excellent stereoselectivities. These resu…
One-pot cross-enyne metathesis (CEYM)-Diels-Alder reaction of gem-difluoropropargylic alkynes.
2013
Propargylic difluorides 1 were used as starting substrates in a combination of cross-enyne metathesis and Diels–Alder reactions. Thus, the reaction of 1 with ethylene in the presence of 2nd generation Hoveyda–Grubbs catalyst generates a diene moiety which in situ reacts with a wide variety of dienophiles giving rise to a small family of new fluorinated carbo- and heterocyclic derivatives in moderate to good yields. This is a complementary protocol to the one previously described by our research group, which involved the use of 1,7-octadiene as an internal source of ethylene.