Search results for "operative"

Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery

2018

Background: Prevention of persistent pain after breast cancer surgery, via early identification of patients at high risk, is a clinical need. Psychological factors are among the most consistently proposed predictive parameters for the development of persistent pain. However, repeated use of long psychological questionnaires in this context may be exhaustive for a patient and inconvenient in everyday clinical practice. Methods: Supervised machine learning was used to create a short form of questionnaires that would provide the same predictive performance of pain persistence as the full questionnaires in a cohort of 1000 women followed up for 3 yr after breast cancer surgery. Machine-learned …

Der Einflu� einer ven�sen Stauung im Kopfbereich auf die Wasser- und Elektrolytausscheidung von Ratten

1960

1. Salt and water retention can be produced in rats by compression in the neck region or by ligature of the jugular veins.

Regulatory evaluation of Glybera in Europe — two committees, one mission

2013

Representing the first gene therapy to be approved in the Western world, alipogene tiparvovec (Glybera; Uniqure) has recently been said to have had a “substantial impact from a regulatory perspective” (Nature Rev. Drug Discov. 11, 664; 2012) 1 . The therapy was granted marketing authorization in the European Union for the treatment of lipoprotein lipase deficiency, which results in a clinically heterogeneous condition with a risk of potentially life-threatening pancreatitis 2 , at the end of 2012. The decision followed a positive opinion by the European Medicines Agency (EMA)’s Committee for Medicinal Products for Human Use (CHMP) 3

Cardiorespiratory disturbances following antibiotic prophylaxis in general surgery: Reasons for a complex reappraisal of a common problem

2016

Problem solving strategies with biomedical and clinimetric components: The case of perioperative H1-+H2-prophylaxis

1992

A formal (objective) problem solving strategy was developed for the question whether a perioperative histamine H1-+H2-prophylaxis should be applied to patients at risk for a histamine release reaction or for a special severity of such a reaction even in the case of a minor histamine release.

Increased Hospital Stay and Allograft Disfunction in Renal Transplant Recipients with Cyp2c19 AA Variant in SNP rs4244285

2012

Pharmacogenetics correlates certain genetic variants, such as single nucleotide polymorphisms (SNPs), with blood drug levels, efficacy, and adverse effects of the treatment. Tacrolimus is mainly metabolized via CYP3A4/5, whereas CYP2C19 and CYP3A4/5 are responsible for omeprazole metabolism. Omeprazole inhibits tacrolimus metabolism via CYP3A5 in patients carrying variant alleles of CYP2C19, increasing tacrolimus blood concentrations. Seventy-five renal transplant recipients treated with tacrolimus and concomitant omeprazole were genotyped in a panel of 37 SNPs with use of Sequenom MassArray. The patients with CYP2C19*2/*2 genotype (n = 4) showed a median posttransplantation hospital stay o…

Cooperative phenomena and light-induced bistability in iron(II) spin-crossover compounds

1999

In iron(II) spin-crossover compounds, the transition from the 1A1 low-spin state at low temperatures to the 5T2 high-spin state at elevated temperatures is accompanied by a large increase in metal-ligand bond lengths. The resulting elastic interactions may be pictured as an internal pressure which is proportional to the concentration of the low-spin species. Because pressure stabilises the low-spin state relative to the high-spin state this results in a positive feedback. Thermal transition curves in neat iron(II) spin-crossover compounds are thus invariable much steeper than in diluted mixed crystals, and the high-spin→low-spin relaxation following the light-induced population of the high-…

Loss induced collective subradiant Dicke behaviour in a multiatom sample

2005

The exact dynamics of $N$ two-level atoms coupled to a common electromagnetic bath and closely located inside a lossy cavity is reported. Stationary radiation trapping effects are found and very transparently interpreted in the context of our approach. We prove that initially injecting one excitation only in the $N$ atoms-cavity system, loss mechanisms asymptotically drive the matter sample toward a long-lived collective subradiant Dicke state. The role played by the closeness of the $N$ atoms with respect to such a cooperative behavior is brought to light and carefully discussed.

The calculation of the mean radiant temperature of a subject exposed to the solar radiation – A generalised algorithm

2005

Abstract The thermal sensation experienced by a subject in a confined environment is significantly affected by the radiative heat exchange between the human body and the surrounding surfaces: it contributes as far as 30% of the whole thermal exchanges of the subject. Besides, the presence of high-intensity radiation sources like, for example, the sun, may appreciably modify the radiant field to which people are exposed. As a consequence, this could alter notably the comfort conditions. In order of properly taking into account this issue, a simple analytical method is introduced in this work, that allows the easy evaluation of the thermal radiant field induced by the presence of the solar ra…

Bifunctional dentifrice: Amorphous polyphosphate a regeneratively active sealant with potent anti- Streptococcus mutans activity

2017

Abstract Objective In this study we demonstrate that inorganic polyphosphate (polyP) exhibits a dual protective effect on teeth: it elicits a strong antibacterial effect against the cariogenic bacterium Streptococcus mutans and, in form of amorphous calcium polyP microparticles (size of 100–400 nm), it efficiently reseals cracks/fissures in the tooth enamel and dentin. Methods Three different formulations of amorphous polyP microparticles (Ca-polyP, Zn-polyP and Sr-polyP) were prepared. Results Among the different polyP microparticles tested, the Ca-polyP microparticles, as a component of a newly developed formulation of a dentifrice, turned out to be most effective in inhibiting growth of …