Search results for "ops"
showing 10 items of 5435 documents
Synthesis of Nortopsentin analogues
2014
Synthesis and antitumor activity of new 7-azaindole derivative nortopsentin analogues
2016
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in…
2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main factors sustaining PDAC progression, the alteration of cell metabolism has emerged to have a key role in PDAC cell proliferation, invasion, and resistance to standard chemotherapeutic agents. Taking into account all these factors and the urgency in evaluating novel options to treat PDAC, in the present work we reported the synthesis of a new series of indolyl-7-azaindolyl triazine compounds inspired by marine bis-indolyl alkaloids. We first assessed the ability of the new triazine compounds to inhibit the enzymatic activity of pyruvate de…
Amygdaloid projections to the ventral striatum in mice: direct and indirect chemosensory inputs to the brain reward system
2011
Rodents constitute good models for studying the neural basis of socio-sexual behaviour. Recent findings in mice have revealed the molecular identity of the some pheromonal molecules triggering intersexual attraction. However, the neural pathways mediating this basic socio-sexual behaviour remain elusive. Since previous work indicates that the dopaminergic tegmento-striatal pathway is not involved in pheromone reward, the present report explores alternative pathways linking the vomeronasal system with the tegmento-striatal system (the limbic basal ganglia) by means of tract-tracing experiments studying direct and indirect projections from the chemosensory amygdala to the ventral striato-pall…
Nudge for justice : An ERP investigation of default effects on trade-offs between equity and efficiency
2020
Default options are an increasingly common tool used by organizations, managers, and policymakers to guide individuals’ behavior. We wondered whether the known preference for default options could constitute a nudge to achieve more equitable or more efficient results. Combining with event-related potentials, we found that both the default option and distributive justice contributed significantly to decision-making. The N200s and P300s were extracted using the tensor decomposition, which showed superiority in terms of capturing multi-domain features. The results demonstrated that greater brain activity associated with conflict monitoring was elicited in the trade-off between equity and effic…
Numerical Magnitude Affects Accuracy but Not Precision of Temporal Judgments
2021
A Theory of Magnitude (ATOM) suggests that space, time, and quantities are processed through a generalized magnitude system. ATOM posits that task-irrelevant magnitudes interfere with the processing of task-relevant magnitudes as all the magnitudes are processed by a common system. Many behavioral and neuroimaging studies have found support in favor of a common magnitude processing system. However, it is largely unknown whether such cross-domain monotonic mapping arises from a change in the accuracy of the magnitude judgments or results from changes in precision of the processing of magnitude. Therefore, in the present study, we examined whether large numerical magnitude affects temporal ac…
Nuorisopsykiatrisen kuntoutuksen perusprosessit : kuntoutushenkilökunnan laatimiin kirjallisiin dokumentteihin perustuva aineistolähtöinen tutkimus
2005
Mitä toi tekee nuorisopsykiatriassa? : toimintaterapeutin työn sisältö ja erityisosaamisen alueet
2011
Tämän Pro gradu –tutkimuksen tavoitteena oli tuottaa kuvaus siitä, millaista on nuorisopsykiatrinen toimintaterapia Suomessa. Tavoitteena oli myös kartoittaa nuorisopsykiatrian erikoisalalla työskentelevien toimintaterapeuttien työn sisältöä ja erityisosaamisen alueita. Aihepiiriin kuuluvia Pro gradu –tutkimuksia on Suomessa julkaistu aiemmin vain yksi. Tutkimusaiheen valintaan vaikutti halu lisätä tutkimuksen keinoin nuorisopsykiatrisen toimintaterapian tunnettavuutta ja vakuuttavuutta osana moniammatillista psykiatrista hoitokulttuuria. Tutkimus toteutettiin laadullisena haastattelututkimuksena. Ryhmähaastatteluihin osallistui 13 nuorisopsykiatrian erikoisalalla työskentelevää toimintater…
Study of the impact of viticultural practices on arbuscular mycorrhizal fungi associated with vines
2021
Arbuscular mycorrhiza, a mutualistic symbiosis established between plants andarbuscular mycorrhizal fungi (AMF), providesmany ecosystem services such as improved soilstructure, increased plant growth and nutrition,and improved tolerance to biotic and abioticstresses. However, intensive agricultural practicesand the use of phytosanitary products as forexample herbicide and fungicides, have a strongimpact on communities of soil microorganisms,including arbuscular mycorrhizal fungi, as well ason biological mechanisms within the ecosystem.This thesis wotk is part of the European Biovineproject supported by the European Commissionthrough the CORE Organic Cofund.The aim of this research work was …
Evaluación de las técnicas de obtención de muestra percutánea transtorácica de lesiones pulmonares y mediastínicas guiadas por Tomografía Computariza…
2023
Las técnicas empleadas para la obtención de muestras de lesiones torácicas, mediante Punción Aspiración con Aguja Fina (PAAF) y Biopsia con Aguja Gruesa (BAG), a partir de punciones percutáneas guiadas por exploraciones radiológicas (con Tomografía Computarizada (TC), fluoroscopia-TC o ecografía), tienen un papel destacado en tres escenarios clínicos concretos: 1) Manejo y diagnóstico del nódulo pulmonar: • Diferenciación benignidad vs malignidad, caracterización anatomopatológica +/- microbiológica. 2) Diagnóstico y estadificación del cáncer de pulmón: • Tipificación anatomopatológica e inmunohistoquímica, realización de estudios moleculares (basales y de resistencia a los tratamientos imp…