Search results for "origen"
showing 10 items of 64 documents
miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance
2015
AbstractThe ErbB tyrosine kinase receptor family has been shown to have an important role in tumorigenesis, and the expression of its receptor members is frequently deregulated in many types of solid tumors. Various drugs targeting these receptors have been approved for cancer treatment. Particularly, in breast cancer, anti-Her2/EGFR molecules represent the standard therapy for Her2-positive malignancies. However, in a number of cases, the tumor relapses or progresses thus suggesting that not all cancer cells have been targeted. One possibility is that a subset of cells capable of regenerating the tumor, such as cancer stem cells (CSCs), may not respond to these therapeutic agents. Accumula…
Discurso pronunciado ante la Sociedad Arqueológica Valenciana
1876
Tema del discurs: "Origen y antiguedad del hombre sobre la tierra"
Molecular Mechanisms Leading from Periodontal Disease to Cancer
2022
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axi…
Origen y condición de "Arse-Saguntum"
1997
En este trabajo se presenta una aproximación al origen y condición de la ciudad saguntina como premisa necesaria para entender su participación en el inicio de la Segunda Guerra Púnica. Especial atención merece el binomio Arse-Saguntum como encubridora de una realidad también dual.
Efficient extraction and preparative separation of four main isoflavonoids from Dalbergia odorifera T. Chen leaves by deep eutectic solvents-based ne…
2016
In this study, green and efficient deep eutectic solvent-based negative pressure cavitation-assisted extraction (DES-NPCE) followed by macroporous resin column chromatography was developed to extract and separate four main isoflavonoids, i.e. prunetin, tectorigenin, genistein and biochanin A from Dalbergia odorifera T. Chen leaves. The extraction procedure was optimized systematically by single-factor experiments and a Box-Behnken experimental design combined with response surface methodology. The maximum extraction yields of prunetin, tectorigenin, genistein and biochanin A reached 1.204, 1.057, 0.911 and 2.448mg/g dry weight, respectively. Moreover, the direct enrichment and separation of…
Onomatopeya, imitación y poesía en Grecia y Roma
2019
A partir de Platón se desarrolla en la reflexión gramatical y filosófica griega la idea de que ciertos vocablos tienen un origen onomatopéyico, tomándose como modelo de su uso (tanto por su conveniencia como por su condena) su aparición en el epos homérico. Mientras la filosofía vinculará tales palabras, entendidas como onomatopeyas, al origen del lenguaje, los autores de poética y gramática las estudiarán como elementos significativos en la valoración estética de la poesía. La doctrina griega sobre la onomatopeya pasará, a su vez, a las letras latinas.