Search results for "otas"
showing 10 items of 1136 documents
Jeffrey Herf. Undeclared Wars with Israel : East Germany and the West German Far Left, 1967–1989.
2018
Non-adrenergic non-cholinergic nerve-mediated inhibitory control of pigeon oesophageal muscle.
1996
Pigeon oesophageal smooth muscle in vitro has spontaneous electromechanical activity. In the presence of atropine and guanethidine, electrical field stimulation evokes a transient TTX-sensitive response comprising inhibition of electric bursting activity and muscular relaxation. This NANC inhibitory response was analysed using the K+ channel blockers TEA and apamin, TEA perfusion (0.1-5 mM) induced a concentration-dependent reduction in amplitude of EFS-evoked relaxation. Responses to higher stimulation frequencies were more sensitive to TEA than those to lower ones. The maximum reduction in amplitude (29% of control) was obtained on 30 Hz EFS evoked responses during 5 mM TEA perfusion. In …
Muscarinic inhibition of potassium-induced noradrenaline release and its dependence on the calcium concentration.
1975
1. Noradrenaline release from the isolated rabbit heart was evoked by perfusion with a medium containing 135 mM potassium and 17 mM sodium ions (high K+-low Na+). 2. The noradrenaline output in response to high K+-low Na+ was dose-dependently decreased by methacholine (0.625-320 muM) and this effect was reserved by atropine 1.44 mM. 3. Lowering the calcium concentration of high K+-low Na+ from 1.8-0.1125 mM decreased the noradrenaline output by 85%. The effect of methacholine, expressed as % inhibition of noradrenaline release, was potentiated by lowering of the calcium concentration. 4. Both at normal and lowered calcium concentrations the inhibitory action of methacholine was larger from …
Absence of muscarinic modulation of vasopressin release from the isolated rat neurohypophysis
1975
1. Isolated rat neurohypophyses were incubated in Locke solution at 37°C and the vasopressin output into the medium determined by bioassay. 2. Potassium chloride 60 mM caused a 9-fold increase in the rate of vasopressin release that was abolished when calcium chloride was omitted from the Locke solution. 3. Acetylcholine 5.5×10−4 M neither alone nor in the presence of atropine 2.9×10−6 M changed the “resting” release of vasopressin. 4. Neither acetylcholine 5.5×10−4 M nor oxotremorine 10−4 and 3×10−4 M altered the vasopressin release evoked by potassium chloride 60 mM. 5. In contrast to the peripheral adrenergic nerve fibres, the secretory terminal fibres of the neurohypophysis do not appea…
Gleznošanas ietekme uz pareiza satvēriena izveidi
2019
Martas Roģes kvalifikācijas darba tēma ir „Gleznošanas ietekme uz pareiza satvēriena izveidi”. Darba autore izvēlējās šo tēmu, jo uzskata, ka tas ir svarīgs priekšnoteikums, lai tiktu sekmīgi apgūta zīmēšana, gleznošana un pirms tiek uzsāktas skolas gaitas arī rakstīšana. Kvalifikācijas darba teorētiskajā daļā tika aplūkoti un analizēti dažādi svarīgi, ar satvērienu saistīti jautājumi un meklēti risinājumi izmantojot dažādus literatūras avotus. Praktiskā pētījuma laikā tika veiktas pārrunas ar bērniem, uzdodot jautājumus saistībā ar tēlotājdarbību, precīzāk, saistībā ar darbu, kurā izmanto guaša krāsas un otu, lai izprastu, kādas ir bērnu intereses konkrētajā jomā. Papildus pārrunām darba a…
Vāļu galu aproces Latvijā: studiju darbs
1944
11,12-EET Stimulates the Association of BK Channel α and β1 Subunits in Mitochondria to Induce Pulmonary Vasoconstriction
2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels. However, in the lung 11,12-EET contributes to hypoxia-induced pulmonary vasoconstriction. Since pulmonary artery smooth muscle cells also express BK channels, we assessed the consequences of BKβ(1) subunit deletion on pulmonary responsiveness to 11,12-EET as well as to acute hypoxia. In buffer-perfused mouse lungs, hypoxia increased pulmonary artery pressure and this was significantly enhanced in the presence of NO synthase (NOS) and cyclooxygenase (…
Properties and roles of BKCa channels in cultured cerebellar granule neuron: Experimental and simulation studies
2006
We studied the properties and roles of large-conductance calcium-sensitive potassium channels (BK"C"a) in cultured rat cerebellar granule neurons. In intact cells these channels had chord conductances of 130-200pS. The conductance, threshold for channel activation and the mean open time and open probability depend on the age of cells. In computer simulations the elimination of BK"C"a channel decreases the maximum and minimum peak values of an action potential, causes reduced hyperpolarization and increases firing frequency. The observed alterations may be linked to the complexity of granule neuron excitability during maturation and provide new insight into modeling the developmental changes…
A comparative biochemical, pharmacological and immunological study of Clostridium novyi alpha-toxin, C. difficile toxin B and C. sordellii lethal tox…
1991
The three clostridial cytotoxins, i.e. alpha-toxin of C. novyi (Tox alpha-nov), toxin B of C. difficile (ToxB-dif) and lethal toxin of C. sordellii (LT-sor) consist of single peptide chains of about 200,000 (Tox alpha-nov), 250,000 (LT-sor) and 275,000 (ToxB-dif) mol. wts. ToxB-dif and LT-sor but not Tox alpha-nov cross-reacted with rabbit polyclonal antibodies. Toxicity upon i.v. injection in mice was similar (LD50, 100 hr, 50-200 ng/kg) and was characterized by a slowly developing fluid loss into the interstitial space. When injected into the rat paw the toxins caused a delayed local edema lasting for days. In vitro the three toxins provoked a persistent retraction of endothelial cells cu…
Zarnu trakta mikrobiotas mainība bērniem antibakteriālas terapijas lietošanas gadījumā
2022
Ievads: Bērnība ir svarīgs periods zarnu mikrobiotas attīstībā. Pētījumi liecina, ka zarnu mikrobiotu ietekmē daudzi faktori no dzimšanas līdz pilngadībai, jo īpaši zarnu mikrobiota ir jutīga pret antibakteriālo ārstēšanu. Tomēr zīdaiņi un mazuļi bieži saņem antibakteriālu ārstēšanu dažādu slimību dēļ, tādējādi ietekmējot zarnu mikrobiotas sastāvu. Mērķis - analizēt zarnu mikrobiotas sastāvu bērniem, kuri saņem antibakteriālu ārstēšanu, salīdzinot dažādu baktēriju taksonomisko vienību relatīvo daudzumu sākotnējā stāvoklī un vienu nedēļu un mēnesi pēc terapijas sākuma un ietekmējošos faktorus bērniem līdz piecu gadu vecumam Latvijā. Metodes: Pētījums ir daļa no garengriezuma pētījuma par bēr…