Search results for "pancreatitis."

PANCREATITIS IN HENOCH-SCHONLEIN PURPURA. A SINGLE CENTRE OBSERVATIONAL STUDY

2018

Introduction: Henoch-Schönlein purpura (HSP) is the most frequent vasculitis in children. Typically, it is characterized by palpable purpura, joints swelling, arthralgia, abdominal pain with possible intestinal bleeding. In more severe cases, the patients show acute abdomen. Acute pancreatitis is a rare dramatically evolutive, life-treating manifestation of SHS and it can be associated with a fulminant course. Persistent abdominal pain, need to be investigated by the dosage of serum pancreatic amylase, lipase and by abdominal MRI. In these patients, corticosteroid treatment is recommended and must be associated with parenteral feeding. Objectives: We analysed the full series of children wit…

Epigenetic Regulation of Early- and Late-Response Genes in Acute Pancreatitis

2015

Abstract Chromatin remodeling seems to regulate the patterns of proinflammatory genes. Our aim was to provide new insights into the epigenetic mechanisms that control transcriptional activation of early- and late-response genes in initiation and development of severe acute pancreatitis as a model of acute inflammation. Chromatin changes were studied by chromatin immunoprecipitation analysis, nucleosome positioning, and determination of histone modifications in promoters of proinflammatory genes in vivo in the course of taurocholate-induced necrotizing pancreatitis in rats and in vitro in rat pancreatic AR42J acinar cells stimulated with taurocholate or TNF-α. Here we show that the upregulat…

Results after 13 years of kidney-pancreas transplantation in type 1 diabetic patients in Comunidad Valenciana

2021

INTRODUCTION Simultaneous pancreas-kidney (SPK) transplant is a proven option of treatment for patients with type 1 diabetes mellitus and related end-stage renal disease, who are candidates for kidney transplantation. The results from the beginning of SPK transplant program in Comunidad Valenciana are presented. METHODS Descriptive, retrospective, and single-center study of the pancreas transplant performed at the Hospital Universitari i Politecnic La Fe, from September 2002 to December 2015. Clinical variables from donors and recipients, peri-operative variables, patient survival, and pancreatic graft survival were collected. RESULTS Eighty-one patients with type 1 diabetes mellitus (48 ma…

Marcadores bioquímicos para predecir la gravedad de la pancreatitis. Revisión sistemática y metaanálisis de precisión diagnostica

2020

Revisión sistemática y metaanálisis de precisión diagnóstica. Contexto: La pancreatitis aguda grave supone hasta el 20% de los casos de pancreatitis aguda, con una mortalidad cercana al 25%, debida a la aparición de complicaciones locales y sistémicas. Se han propuesto múltiples sistemas y marcadores para predecir esta gravedad. Objetivo: Este trabajo buscó evaluar la capacidad de la proteína C reactiva, la procalcitonina y el dímero D para predecir la pancreatitis aguda grave, medida mediante escalas de gravedad. Métodos: Se realizó una revisión sistemática en Medline, CENTRAL, Embase, Web of Science, clinical trials, literatura gris y revisión de las referencias de artículos elegibles, di…

Identification and diagnosis of patients with familial chylomicronaemia syndrome (FCS): Expert panel recommendations and proposal of an "FCS score".

2018

Familial chylomicronaemia syndrome (FCS) is a rare, inherited disorder characterised by impaired clearance of triglyceride (TG)-rich lipoproteins from plasma, leading to severe hypertriglyceridaemia (HTG) and a markedly increased risk of acute pancreatitis. It is due to the lack of lipoprotein lipase (LPL) function, resulting from recessive loss of function mutations in the genes coding LPL or its modulators. A large overlap in the phenotype between FCS and multifactorial chylomicronaemia syndrome (MCS) contributes to the inconsistency in how patients are diagnosed and managed worldwide, whereas the incidence of acute hypertriglyceridaemic pancreatitis is more frequent in FCS. A panel of Eu…

Regulation of protein cysteinylation and the inflammatory cascade by thioredoxin-related protein of 14 kDa in pancreas

2020

Although under physiological conditions ROS are essential for normal cell signaling, ROS overproduction under oxidative stress conditions may cause damage to biomolecules. Cysteine residues within proteins are often easily oxidized. Reversible cysteine oxidation is used as a mechanism of redox signaling and control of protein function. However, oxidative stress promotes oxidation of protein thiols, leading to the formation of mixed disulfides between proteins and low-molecular-weight thiols. Disulfide reductases such as thioredoxins can reduce disulfide bonds back to free thiols. Acute pancreatitis is currently one of the leading causes of hospital admission for gastrointestinal disorders, …

The unsolved question of acute pancreatitis. prognostic criteria: A case report

2014

Type 2 Diabetes as a Factor Modifying the Course and Prognosis of Acute Pancreatitis

2022

Acute pancreatitis (AP) and type 2 diabetes (T2D) are diseases with steadily increasing incidence. On the one hand, the presence of diabetes increases the risk of AP development; on the other hand, there is a question whether the presence of T2D adversely affects the course and prognosis of AP. In this study we attempted to demonstrate the adverse effect of T2D on the course and prognosis of AP. Materials and methods:The retrospective study analyzed the data of 333 patients with the diagnosis of AP in the Internal Medicine Department of the University Hospital in Opole between 2015 and 2019. The patients were divided into two groups: with T2D and without T2D. The comparative analysis includ…

Italian consensus guidelines for chronic pancreatitis

2010

COVID-19 and the Pancreas: A Narrative Review.

2022

The outbreak of COVID-19, initially developed in China in early December 2019, has rapidly spread to other countries and represents a public health emergency of international concern. COVID-19 has caused great concern about respiratory symptoms, but it is worth noting that it can also affect the gastrointestinal tract. However, the data on pancreatic involvement during SARS-CoV-2 infection are limited. The prevalence and severity of pancreatic damage and acute pancreatitis, as well as its pathophysiology, are still under debate. Moreover, the possible implication of pancreatic damage as an apparent adverse effect of COVID-19 therapies or vaccines are issues that need to be addressed. Finall…