Search results for "parietal cortex"
showing 10 items of 83 documents
TMS activation of interhemispheric pathways between the posterior parietal cortex and the contralateral motor cortex
2009
Using a twin coil transcranial magnetic stimulation (tc-TMS) approach we have previously demonstrated that facilitation may be detected in the primary motor cortex (M1) following stimulation over the ipsilateral caudal intraparietal sulcus (cIPS). Here we tested the interhemispheric interactions between the IPS and the contralateral motor cortex (M1). We found that conditioning the right cIPS facilitated contralateral M1 when the conditioning stimulus had an intensity of 90% resting motor threshold (RMT) but not at 70% or 110% RMT. Facilitation was maximal when the interstimulus interval (ISI) between cIPS and M1 was 6 or 12 ms. These facilitatory effects were mediated by interactions with …
Temporo-Parietal Junction modulates self-other motor representations during on-line and off-line social motor conflict: an rTMS study
2015
The temporal-parietal junction (TPJ) is a brain area implicated in social cognition, attention, integrating body-related information and self-processing. We investigated involvement of both the left and the right TPJ in a complex social cognitive task that required attributing intentions to other people. Fourteen healthy subjects participated in experiments that involved simulating interactions with other people in everyday conflicting situations. The task was performed following application of inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) to the right and the left TPJ and to a control occipital brain site. Results showed a different pattern of involvement for the…
Interazione tra diversi codici attenzionali: spazio e semantica
2010
The asymmetric distribution of human spatial attention has been repeatedly documented in both patients and healthy controls. Biases in the distribution of attention and/or in the mental representation of space may also affect some aspects of language processing. The present talk will be focused whether biases in attention and/or mental representation of space affect semantic representations. In particular, we investigated whether semantic judgments could be modulated by the location in space where the semantic information was presented and the role of the left and right parietal cortices in this task. Findings suggest the existence of an attentional and/or mental representational bias in se…
EFFECTS OF TMS OVER RIGHT POSTERIOR PARIETAL CORTEX AND VISUOSPATIAL NEGLECT IN NEAR AND FAR SPACE USING LINE BISECTION
2011
PB15. Neurophysiological biomarker for the clinical development of tuberous sclerosis
2018
Aim To investigate the neuronal networks in children with tuberous sclerosis complex (TS) undergoing treatment with Everolimus. Methods Sleep and wake electroencephalography (EEG) before and one year after the start of the treatment with Everolimus were investigated in 13 patients with TS. To investigate functional and effective connectivity within the network generating the delta and theta activity in the background sleep and wake EEG, the methods of dynamic imaging of coherent sources (DICS) and renormalized partial directed coherence (RPDC) were applied. Results Sources before the treatment . Independent of location of the tubera and severity of epilepsy, delta activity in the background…
Improving neglect by TMS.
2006
Hemispatial neglect refers to the defective ability of patients to explore or act upon the side of space contralateral to the lesion and to attend to stimuli presented in that portion of space. Evidence from animal models suggests that many of the behavioural sequelae associated with visual neglect may result not solely from the size of the lesion, but also from a pathological state of increased inhibition exerted on the damaged hemisphere by the contralesional hemisphere. On the basis of these potential mechanisms underlying neglect, in this review we discuss therapeutic approaches, focusing particularly on recent research using transcranial magnetic stimulation (TMS). This technique, besi…
Suppression of extinction with TMS in humans: from healthy controls to patients.
2006
We review a series of studies exemplifying some applications of single-pulse and paired-transcranial magnetic stimulation (TMS) in the study of spatial attention and of its deficits. We will focus primarily on sensory extinction, the failure to consciously perceive a contralesional sensory stimulus only during bilateral stimulation of homologous surfaces. TMS studies in healthy controls show that it is possible either to interfere or modulate the excitability of the parietal cortex during sensory (i.e. tactile and visual) attentional tasks, thus reproducing a condition of virtual extinction. TMS studies in patients with unilateral (mainly right) brain damage show that the modulation of the …
Multifocal TMS for temporo-spatial description of cortico-cortical connectivity patterns
2016
Chronic neural probe for simultaneous recording of single-unit, multi-unit, and local field potential activity from multiple brain sites
2017
Drug resistant focal epilepsy can be treated by resecting the epileptic focus requiring a precise focus localisation using stereoelectroencephalography (SEEG) probes. As commercial SEEG probes offer only a limited spatial resolution, probes of higher channel count and design freedom enabling the incorporation of macro and microelectrodes would help increasing spatial resolution and thus open new perspectives for investigating mechanisms underlying focal epilepsy and its treatment. This work describes a new fabrication process for SEEG probes with materials and dimensions similar to clinical probes enabling recording single neuron activity at high spatial resolution.Polyimide is used as a bi…
A Knowledge-Based System for the Diagnosis of Alzheimer’s Disease
2003
Therapies to slow down the progression of Alzheimer’s disease are most effective when applied in its initial stages. Therefore it is important to develop methods to diagnose the disease as early as possible. It is also desirable to establish standards which can be used generally by physicians who may not be experts in diagnosis of the disease. One possible method to obtain an early diagnosis is the evaluation of the glucose metabolism of the brain. In this paper we present a prototype of an expert system that automatically diagnoses Alzheimer’s disease on the basis of positron emission tomography images displaying the metabolic activity in the brain.