Search results for "passion"
showing 10 items of 188 documents
Plerixafor is effective and safe for stem cell mobilization in heavily pretreated germ cell tumor patients.
2010
Up to 10% of germ cell tumor patients require salvage high-dose chemotherapy with stem cell support, achieving cure rates in the range of 10-60%. Stem cell mobilization may be difficult in these patients because of multiple lines of treatment known to seriously hamper stem cell recovery. Plerixafor significantly enhances the success of the CD34+ cell harvest, even in cases where prior mobilization attempts have failed. Six germ cell tumor patients provided informed consent and were included in the compassionate use program. All patients were heavily pretreated, with a median of 3.5 prior lines of therapy. All failed prior mobilization with G-CSF in combination with chemotherapy. Five patien…
Final results of the European Advanced Renal Cell Carcinoma Sorafenib (EU-ARCCS) expanded-access study: a large open-label study in diverse community…
2011
Background The European Advanced Renal Cell Carcinoma Sorafenib (EU-ARCCS) expanded-access study provided sorafenib to advanced renal cell carcinoma (RCC) patients in whom previous systemic therapy had failed. The study assessed the safety and use of sorafenib for the treatment of advanced RCC in a large community-based patient population across 11 countries in Europe. Patients and methods EU-ARCCS was a single-arm, open-label trial of sorafenib in advanced RCC patients. End points included safety, time to progression, progression-free survival (PFS), and disease control rate (DCR). Subgroup analyses included age, Eastern Cooperative Oncology Group performance status, histology, prior thera…
Polatuzumab Vedotin in Relapsed and Refractory (r/r) Large B-Cell Lymphoma (LBCL): Real-World Data of the German National Compassionate Use Program (…
2020
Introduction The antibody-drug conjugate polatuzumab vedotin (Pola) has recently been approved in combination with bendamustine and rituximab (Pola-BR) for patients with r/r diffuse LBCL (DLBCL). Methods To characterize the efficacy of Pola-BR in a real-world setting, we retrospectively analyzed data from 97 patients with r/r LBCL who were treated with Pola in 24 German centers within the national CUP. Clinical baseline and follow-up (FU) data were collected by chart review and summarized descriptively. Progression-free survival (PFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox regression methods. Fisher's exact test was used to compare categorical factors between gro…
In the shadow of COVID-19: A randomized controlled online ACT trial promoting adolescent psychological flexibility and self-compassion.
2023
Background Although some adolescents managed to cope well with the challenges brought on by the COVID-19 pandemic, the well-being of many was adversely affected due to school closures, distance education, restrictions on gathering with friends, and limited access to mental health services. Many adolescents reported increased anxiety and depression as well as decreased psychological wellbeing due to the pandemic. Consequently, there is a need for psychological support that exceeds the strained resources available to schools to support young people during times of crisis and societal pressure. Objective The present study aimed to explore the effects of an online-delivered ACT intervention to …
Palliative Care Professionals’ Inner Life: Exploring the Mediating Role of Self-Compassion in the Prediction of Compassion Satisfaction, Compassion F…
2021
Context. Palliative care professionals are exposed to suffering on a daily basis. Working in such an environment frequently raises existential issues, psychological challenges, and emotional distress, that can detract from compassionate care. Identifying factors that help professionals cope with frequent exposure to issues related to mortality, such as compassion, could enhance palliative care providers’ and patients’ quality of life and wellbeing. Objectives. To improve our understanding of the factors associated with professionals’ inner life studying the role of self-compassion as a mediating variable between self-care and awareness and professionals’ quality of life, and quantifying the…
O sujeito do conhecimento – o objeto da ação: a “passagem”, identidade e diferença na filosofia de Arthur Schopenhauer
2009
In the present text, I’ll dwell upon the tensions or contradictions in the philosophy of Schopenhauer, and I’ll try to understand them instead of accusing the philosopher of irrationality or inconsequence. The first part of the text investigates Schopenhauer’s theory of knowledge under the aspects of difference and passage, and the second part investigates the liason between etchis and aesthetics searching for an answer for the question of the present identity in the determination of compassion as an expression of the knowledge of the unity of the will.
Assassinio passionale
2007
Sulla rappresentazione letteraria dell’assassinio passionale About crime of passion’s literary representation, its constants and its changes
Phenomenology of the Poetical
2004
These lines from “The Doctrine of the Point of View” by Jose Ortega y Gasset, the fragment devoted to the ever-existing antinomy between life and culture and their interpretations from the rationalistic and relativistic view points, are the perfect opening for the present paper as they capture the sense and the mood of the philosophical endeavor taken upon by Anna-Teresa Tymienicka in Poetica nova and Book 3 of Logos and Life: The Passions of the Soul and the Elements into Onto-Poiesis of Culture. In short it could be summarized as the inquiry into phenomenology of the poetical with a special emphasis on literature as the prima facie human creative activity to be approached by the means of …
Eurípides: de la moral pensada a la moral vivida
2011
ResumenLa tragedia griega sigue siendo un gran referente de reflexión filosófica. En este artículo nos centraremos en la figura de Eurípides, concretamente en el tema de los juicios morales que trasmiten sus obras trágicas. La cuestión es que si en Esquilo la razón triunfaba sobre el dilema trágico, en Eurípides no se ve claro ese triunfo si viene impuesto desde fuera y no ha arraigado en el corazón de los ciudadanos. La razón tiene muchas dificultades para ejercer su control sobre la acción y orientarla hacia el bien común. Eurípides planteará que es la persona, su conciencia interior, la que debe de estar convencida de que algo le obligue moralmente. El paso de una moral pensada a una mor…
Can the Excluded Criticize? On the (Im)possibilities of Formulating and Understanding Critique
2021
If critique does not want to be more than just a ‘passion of the head’ it has to engage in dialogue with the worst-off in society. However, there are several mechanisms that hinder the excluded fro...