Search results for "patch"

IL PATCHING ILEO-ILEALE NELLA PREVENZIONE DELLA SINDROME DA RESEZIONE INTESTINALE MASSIVA, RICERCHE SPERIMENTALI

1977

Gli Autori eseguono un patching ileo-ileale allo scopo di aumentare la superficie di assorbimento intestinale; espongono i risultati ottenuti su 50 ratti albini; descrivono i reperti istologici e istoenzimatici effettuati sulla mucosa neoformata

Transdermal and Skin-Targeted Drug Delivery

1997

Background: The application of therapeutic agents to the skin addresses three general objectives: (a) the treatment of a variety of dermatologic diseases; (b) the “targeted” delivery of drugs to deeper subcutaneous tissues, with a concomitant reduction in systemic exposure; and (c) socalled transdermal administration to elicit a systemic pharmacologic effect. Objective: Recently, significant progress towards all three goals has been recorded and the level of research and development activity remains high. We aim to discuss these advances from mechanistic and clinical standpoints. Results: For the topical treatment of skin disease, novel vehicles (e.g., stabilized, supersaturated systems and…

Stable expression in HEK-293 cells of the rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor.

1996

The alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) was stably expressed in human embryonic kidney (HEK) 293 cells that co-expressed a voltage-gated Ca2+ channel. alpha3/beta4-nAChR-expressing clones were identified using the fura-2 Ca2+ imaging technique, and were further characterised by single-cell and whole-cell patch-clamp studies. Acetylcholine (ACh) induced fast activating currents which showed desensitisation and inward rectification. The conductance of the ACh-activated channel was 29 pS. The order of potency of the nicotinic agonists tested was cytisine approximately = nicotine > acetylcholine. The EC50 value for ACh was 145 microM; the Hill coefficient w…

Structures with Surface-Bonded PZT Piezoelectric Patches: a BEM Investigation into the Strain-transfer Mechanism for SHM applications

2009

In this work a three-dimensional BEM model is used for the analysis of structures with cracks and surface bonded piezoelectric PZT patches used as strain sensors. The cracked structure is modelled by the dual boundary element method, which allows for accurate and reliable crack analysis, while the piezoelectric patch is analyzed by a finite element state-space approach, that embodies both the full electro-mechanical coupling and the suitable sensor’s boundary conditions. The model is used to investigate the strain-transfer mechanism from an host elastic structure to the piezoelectric layer, taking into account the effect of the adhesive layer, as well as the mechanical interaction between t…

TRPV1 channels as putative targets in the cannabinoid-mediated synaptic activity of hippocampal neurons

Endocannabinoids (eCBs) play a critical part in pathophysiological conditions rooted on neuronal excitability such as epilepsy. eCBs seem to be involved in neuroprotection, putatively acting on the cannabinoid receptor type 1 (CB1r), but also on Transient Receptor Potential Vanilloid type 1 channels (TRPV1). Indeed, CB1r and TRPV1 are involved in the transduction of stimuli at synaptic level, though exact molecular mechanisms are far from being unveiled. Thus, we aimed to investigate the role of CB1r/TRPV1 interplay in the rat hippocampal neurotransmission by whole-cell patch clamp technique to evaluate excitatory bioelectric activity in the CA1. We pharmacologically manipulated this pathwa…

Abitare nel reale. Dalla crisi della periferia alla tessitura di nuove relazioni contestuali

2019

I progetti redatti per “Palermo Sud-Est” sono il risultato di un Laboratorio di Laurea strutturatosi attraverso incontri, seminari, comunicazioni specialistiche, esposizioni critiche, che – in una strategia condivisa – ha visto ogni studente elaborare il proprio lavoro nel confronto con gli altri attori del Laboratorio stesso. La ricerca sui “progetti urbani” è stata impostata di modo che ogni laureando fosse messo a conoscenza dei progetti svolti nello stesso ambito territoriale dai colleghi che l’avevano preceduto, così da poter operare in continuità e contribuire a formulare un ragionamento unitario, nel quale ogni progetto costituisse continuazione, verifica o anche variante dei precede…

002 Impact of diverting general practitioner's after-hours calls to emergency medical dispatch centers on time delays and acute revascularization pro…

2012

Jean Ferrieres [Orateur] (1), Guy Berkenboom (2), Zdenek Coufal (3), Stefan James (4), Attila MohaCsi (5), Gregory Pavlides (6), Kirsi Norrbacka (7), Magali Sartral (8), Marie-Ange Paget (8), Molly Tomlin (9), Uwe Zeymer (10) (1) CHU Rangueil, Cardiologie B, Toulouse, France – (2) ULB Erasme University Hospital, Department of Cardiology, Brussels, Belgium – (3) Batova Krajska Nemocnice Zlin, Department of Cardiology, Zlin, Republique Tcheque – (4) Uppsala University Hospital, Dept. of Cardiology and Uppsala Clinical Research Center, Uppsala, Suede – (5) Gottsegen Institute of Hungarian Cardiology, Budapest, Hungaria – (6) Onassis Cardiac Surgery Center, Kallithea, Grece – (7) Lilly Research…

A structural comparison of halloysite nanotubes of different origin by Small-Angle Neutron Scattering (SANS) and Electric Birefringence

2018

The structure of halloysite nanotubes (Hal) from different mines was investigated by Small-Angle Neutron Scattering (SANS) and Electric Birefringence (EBR) experiments. The analysis of the SANS curves allowed us to correlate the sizes and polydispersity and the specific surfaces (obtained by a Porod analysis of the SANS data) of the nanotubes with their specific geological setting. Contrast matching measurements were performed on patch Hal (from Western Australia) in order to determine their experimental scattering length density for a more precise analysis. Further characterization of the mesoscopic structure of Hal was carried out by Electric Birefringence (EBR), which allowed to study th…

Electrophysiological and morphological properties of Cajal–Retzius cells with different ontogenetic origins

2010

International audience; The different origins of Cajal-Retzius cells (CRc) as well as their diverse molecular profile suggest that this cell type may represent different neuronal subpopulations. In order to investigate whether CRc from different origins show distinct functional or morphological characteristics we used transgenic Dbx1(cre);ROSA26(YFP) mice in which two subpopulations of CRc, originating from the septum and ventral pallium (VP) at the pallial-subpallial border (PSB), were permanently labeled by yellow fluorescent protein (YFP) expression. Electrophysiological properties of YFP(+) and YFP(-) CRc were investigated by whole-cell patch-clamp recordings, while a thorough somatoden…

Source separation on hyperspectral cube applied to dermatology

2010

International audience; This paper proposes a method of quantification of the components underlying the human skin that are supposed to be responsible for the effective reflectance spectrum of the skin over the visible wavelength. The method is based on independent component analysis assuming that the epidermal melanin and the dermal haemoglobin absorbance spectra are independent of each other. The method extracts the source spectra that correspond to the ideal absorbance spectra of melanin and haemoglobin. The noisy melanin spectrum is fixed using a polynomial fit and the quantifications associated with it are reestimated. The results produce feasible quantifications of each source compone…