Search results for "path"

Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)

2008

BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contra…

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

2022

Source data of the paper Ketkar, Gür, Molina-Obando et al. 2022, eLife. We analyzed the behavioral contribution and physiological response properties of first order interneurons L1, L2 and L3 in the Drosophila melanogaster visual system. Data are sorted by figures and comprise either behavioral measurements of flies walking on an air-cushioned ball while being shown visual stimuli, or in vivo two photon microscopy recordings of L1-L3 calcium responses. Please find all relevant information to use the data in the README file. The code to analyze the data, either written in Matlab or Python, is found at https://github.com/silieslab/Ketkar-Gur-MolinaObando-etal2022

(A,B) In vivo GCaMP6f signals recorded in layers M1, M5 and M9/10 of Mi1 (A) and Tm3 (B) neurons, before (blue, green) and after (gray, red) applicat…

2019

Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specifi…

Anatomic and functional follow-up of patients with an idiopathic epiretinal membrane and a preserved visual acuity

2013

Purpose: To determine the anatomic and functional retinal modifications in patients with an idiopathic epiretinal membrane (ERM) and a preserved visual acuity (VA).Methods: Monocentric, prospective study in 24 eyes of 24 patients with an ERM and a VA better than 20/25. Recorded data were best corrected VA on ETDRS scale, retinal anatomic lesions on spectral-domain OCT, retinal sensitivities on microperimetry and macular and foveal thicknesses at 0 and 6 months.Results: At inclusion, mean VA was 84 ± 5 letters, mean macular sensitivity was 14.0 ± 1.4 decibels (dB) and mean foveal sensitivity was 14,4 ± 1,5 dB. Mean macular thickness was 351 ± 34 µm and mean foveal thickness was 348 ± 66 µm. …

Motion perception in early glaucoma

2013

Purpose: The aim of our study was to underline the changes in the movement perception for early glaucoma. Our working hypothesis consisted in inquiring if the impairment of the magnocellular pathway may modify the movement perception capabilities in the visual field, more particularly in its peripheral area.Methods: We included 14 healthy subjects and 14 patients with early primary open angle glaucoma. A moving target was presented on a semicircular screen (1.8 m diameter); participants were asked to localize the Ending Point (EP) of each movement. Each stimulus consisted in a white dot (0,72° of diameter) moving horizontally with the imposed velocity profile. Two different laws of motion w…

Empathy, Entrainment, and Perceived Interaction in Complex Dyadic Dance Movement

2019

The current study explores how individuals' tendency to empathize with others (trait empathy) modulates interaction and social entrainment in dyadic dance in a free movement context using perceptual and computationally derived measures. Stimuli consisting of 24 point-light animations were created using motion capture data selected from a sample of 99 dyads, based on self-reported trait empathy. Individuals whose Empathy Quotient (EQ) scores were in the top or bottom quartile of all scores were considered to have high or low empathy, respectively, and twelve dyads comprised of four high-high, four low-low, and four high-low empathy combinations were identified. Animations of these dyads were…

"Kyllä minä tästä selviän" : aikuisopiskelijat koulutustarinansa kertojina ja koulutuksellisen minäpystyvyytensä rakentajana

2011

The impact of store atmospherics and store layout on customer behavior in a hardware store retail setting : case: do-it-yourself store

2015

Comprehensive apprehension of retail establishment’s atmosphere’s effects on its cus-tomers’ overall perceptions of the store and thus purchasing behavior is an essential goal for any retailer, yet the previous marketing literature has converged on understanding the shopping environments of mostly malls, grocery stores, furniture stores and clothing stores. A window was left open for construing a wholly different shopping environment; DIY (do-it-yourself)/ hardware/ home improvement store. Shopping environment studies rely largely on environmental psychology theories in their attempts of deciphering the effects of environment on individuals. This study is fundamentally similar in nature, by…

H&E Multi-Laboratory Staining Variance Exploration with Machine Learning

2022

In diagnostic histopathology, hematoxylin and eosin (H&E) staining is a critical process that highlights salient histological features. Staining results vary between laboratories regardless of the histopathological task, although the method does not change. This variance can impair the accuracy of algorithms and histopathologists’ time-to-insight. Investigating this variance can help calibrate stain normalization tasks to reverse this negative potential. With machine learning, this study evaluated the staining variance between different laboratories on three tissue types. We received H&E-stained slides from 66 different laboratories. Each slide contained kidney, skin, and colon tissue sampl…

Foot loading in normal and pathological walking

2002

Perusteellinen kävely- ja kuormitusanalyysi on usein tarpeellinen jalkaongelmissa, jotta mahdollinen tukien ja ortoosien valinta sekä alaraajoihin kohdistuvien leikkausten jälkeinen kuntoutus pystytään suorittamaan parhaalla mahdollisella tavalla, toteaa Jarmo Perttunen väitöstutkimuksessaan. Kävelijä tuottaa tukivaiheen aikana alustaan voimia pysty- ja vaakasuunnassa, joita on perinteisesti mitattu voimalevyantureilla. Ne eivät pysty yksistään erottelemaan kuormitusta jalkapohjan eri osien välillä riittävän täsmällisesti. Kiinnostus selvittää kuormitus tarkasti on johtanut kehityksen alkeellisista jalkapohjan mustekuvista hyvin pieniin kengän sisälle asetettaviin mittausantureihin. Perttus…