Search results for "paz"
showing 10 items of 1302 documents
Aspazijas personības un daiļrades apguve 11. klasē
2019
Diplomdarba „Aspazijas personības un daiļrades apguve 11. klasē” mērķis ir izveidot metodiskās sistēmas variantu, kas veicinātu skolēnu interesi par literatūru un rosinātu pētīt Aspazijas daiļradē rodamās idejas. Darbam ir piecas nodaļas ar apakšnodaļām, ievads, secinājumi un pielikumi. Pirmajā nodaļā iepazīta Aspazijas personība un tās ietekme uz dzejnieces daiļradi, kā arī Aspazijas dzejas un drāmas specifika, uzsverot skolēniem noderīgo informāciju. Otrajā nodaļā ir apzināta teorētiskā literatūra par literatūru kā mācību priekšmetu un tā specifiku. Trešajā nodaļā ir aprakstīta skolotāja sagatavošanās darbam klasē, iekļaujot skolēnu vecumposma īpatnības, pētījumā iesaistīto skolēnu rakstu…
Los ‘disparates espaciales’ como mecanismos de la comicidad en la comedia burlesca del Siglo de Oro.
2011
Il lavoro analizza la dimensione dello ‘spazio drammatico’ nel genere della commedia burlesca del Siglo de Oro, fornendo numerosi esempi di quelli che vengono qui denominati ‘disparates espaciales’: non si tratta di costruzioni complesse, ma di piccoli ed incoerenti frammenti che arrivano a mescolare riferimenti a luoghi reali e conosciuti allo spettatore dell’epoca e allusioni a luoghi lontani, esotici o inesistenti. In questo modo, i ‘disparates espaciales’ contribuiscono alla ‘provocación de la risa’ e, insieme agli altri elementi caratteristici della commedia burlesca, collaborano alla costruzione del ‘mundo al revés’ tipico del genere.
La DaD nell’emergenza Covid19: restrizione spaziale e sfida per una nuova temporalizzazione
2020
L’introduzione della DaD nell’università, come risposta di emergenza alla pandemia del Covid19, ha comportato inevitabilmente il sacrificio della dimensione spaziale nel percorso formativo degli studenti e nella loro socialità. Questa restrizione, tuttavia, può creare il presupposto per riguadagnare in intensità ciò che si perde in estensione e ripensare, in termini filosofici, il rapporto tra temporalizzazione e spazializzazione nel processo di costruzione della personalità nella sua coscienza storica. The introduction of the DDA in the university, as an emergency response to the Covid19 pandemic, inevitably entailed the sacrifice of the spatial dimension in the training of students and in…
An investigation into the fracture behaviour of honeycombs with density gradients
2020
International audience; In this study we perform an experimental and computational investigation about the fracture behaviour of polymer honeycombs presenting gradients in terms of lattice density. Such lattice relative density variations are introduced with the aim of mimicking the micro-morphology encountered in some natural materials, such as several kinds of woods, which seems related to the ability of the corresponding macro-material to delay the propagation of fracture under certain conditions. Starting from the conclusions of previous computational analyses, we perform a few experimental tensile tests on ABS model honeycombs obtained by additive manufacturing, with the aim of getting…
Preliminary design process for an adaptive winglet
2017
In the framework of Clean Sky 2 Airgreen 2 GRA ITD project, this paper deals with the design process of a morphing winglet for a regional aircraft. By improving A/C aerodynamic efficiency in off-design flight conditions, the morphing winglet is expected to operate during long (cruise) and short (climb and descent) mission phases to reduce aircraft drag and optimize lift distribution, while providing augmented roll and yaw control capability. The mechanical system is designed to face different flight situations by a proper action on the movable parts represented by two independent and asynchronous control surfaces with variable camber and differential settings. A set of suitable electromecha…
Buckling and post-buckling analysis of cracked stiffened panels via an X-Ritz method
2019
Abstract A multi-domain eXtended Ritz formulation, called X-Ritz, for the analysis of buckling and post-buckling of stiffened panels with cracks is presented. The theoretical framework is based on the First-order Shear Deformation Theory and accounts for von Karman's geometric nonlinearities. The structure is modeled as assembly of plate elements. Penalty techniques are used to fulfill the continuity condition along the edges of contiguous elements and to satisfy essential boundary conditions requirements. The use of an extended set of approximating functions allows to model through-the-thickness cracks and to capture the crack opening and tip singular fields as well as the structural behav…
Xenograft models for undifferentiated pleomorphic sarcoma not otherwise specified are essential for preclinical testing of therapeutic agents
2016
Undifferentiated pleomorphic sarcoma not otherwise specified belongs to the heterogeneous group of soft tissue tumors. It is preferentially located in the upper and lower extremities of the body, and surgical resection remains the only curative treatment. Preclinical animal models are crucial to improve the development of novel chemotherapeutic agents for the treatment of undifferentiated pleomorphic sarcoma. However, this approach has been hampered by the lack of reproducible animal models. The present study established two xenograft animal models generated from stable non-clonal cell cultures, and investigated the difference in chemotherapeutic effects on tumor growth between undifferenti…
Trabectedin for patients with advanced soft tissue sarcoma: A non-interventional, retrospective, multicenter study of the italian sarcoma group
2021
The Italian Sarcoma Group performed this retrospective analysis of patients with advanced soft tissue sarcoma, pretreated with ≥1 anthracycline-based treatment, and treated with trabectedin every three weeks. Primary endpoint was to describe real-life use of trabectedin across Italy. Secondary endpoints included objective response rate (ORR) and safety. Overall, 512 patients from 20 Italian centers were evaluated. Leiomyosarcoma (37.7%)/liposarcoma (30.3%) were the most prevalent histological types (abbreviated as L-sarcoma). Patients received a median of four trabectedin cycles (range: 1–40), mostly as a second-line treatment (~60% of patients). The ORR was 13.7% superior (p <
Pazopanib for treatment of typical solitary fibrous tumours: a multicentre, single-arm, phase 2 trial
2020
[Background] Solitary fibrous tumour is an ultra-rare sarcoma, which encompasses different clinicopathological subgroups. The dedifferentiated subgroup shows an aggressive course with resistance to pazopanib, whereas in the malignant subgroup, pazopanib shows higher activity than in previous studies with chemotherapy. We designed a trial to test pazopanib activity in two different cohorts of solitary fibrous tumour: the malignant-dedifferentiated cohort, which was previously published, and the typical cohort, which is presented here.
Real-World Data on Cabozantinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma: Focus on Sequences and Prognostic Factors
2019
Cabozantinib is approved for the treatment of renal cell carcinoma (RCC). However, prognostic factors are still lacking in this context. The aim of this study was to evaluate prognostic factors in RCC patients treated with second- or third-line cabozantinib. A multicenter retrospective real-world study was conducted, involving 32 worldwide centers. A total of 237 patients with histologically confirmed clear-cell and non-clear-cell RCC who received cabozantinib as second- or third-line therapy for metastatic disease were included. We analyzed overall survival (OS), progression-free survival (PFS) and time-to-strategy failure (TTSF) using Kaplan&ndash