Search results for "peli"
showing 10 items of 1060 documents
Postnatal Overfeeding Causes Early Shifts in Gene Expression in the Heart and Long-Term Alterations in Cardiometabolic and Oxidative Parameters
2013
International audience; Background: Postnatal overfeeding (OF) in rodents induces a permanent moderate increase in body weight in adulthood. However, the repercussions of postnatal OF on cardiac gene expression, cardiac metabolism and nitro-oxidative stress are less well known. Methodology/Principal Findings: Immediately after birth, litters of C57BL/6 mice were either maintained at 10 (normal-fed group, NF), or reduced to 3 in order to induce OF. At weaning, mice of both groups received a standard diet. The cardiac gene expression profile was determined at weaning and cardiac metabolism and oxidative stress were assessed at 7 months. The cardiac expression of several genes, including membe…
Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes
2014
Aims: We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. An intracerebroventricular (icv) injection of a high dose of apelin, similar to that observed in obese/diabetic mice, increase fasted glycemia, suggesting (i) that apelin contributes to the establishment of a diabetic state, and (ii) the existence of a hypothalamic to liver axis. Using pharmacological, genetic, and nutritional approaches, we aim at unraveling this system of regulation by identifying the hypothalamic molecular actors that trigger the apelin effect on liver gluc…
Registration-based Construction of a Whole-body Human Phantom Library for Anthropometric Modeling.
2020
Various computational human phantoms have been proposed in the past decades, but few of them include delicate anthropometric variations. In this study, we build a whole-body phantom library including 145 anthropometric parameters. This library is constructed by registration-based pipeline, which transfers a standard whole-body anatomy template to an anthropometry-adjustable body shape library (MakeHuman™). Therefore, internal anatomical structures are created for body shapes of different anthropometric parameters. Based on the constructed library, we can generate individualized whole-body phantoms according to given arbitrary anthropometric parameters. Moreover, the proposed phantom library…
Mobiiliopetuksen käyttömahdollisuuksia : oppilaiden omien mobiililaitteiden käyttö peruskoulun alakoulun opetuksessa
2015
Muutaman viime vuoden aikana mobiililaitteiden käyttö kouluissa on yleistynyt. Tämä on osittain aiheuttanut ristiriitaista keskustelua laitteiden käytöstä opetuksessa. Osa opettajista on ottanut mobiililaitteet opetuskäyttöön innokkaasti. Mobiiliopetuksen mahdollisuuksia ei kuitenkaan ole vielä kovin paljon tutkittu. Tällä tutkimuksella oli tarkoitus selvittää, mitä mahdollisuuksia oppilaiden omat mobiililaitteet tarjoavat opetukseen. Aineiston analyysissa pyrittiin etsimään tietoa siitä, miten ongelma-perustaisen opetuksen menetelmä ja pelillisyys vaikuttavat opetus- ja oppimisprosessissa, kun opiskelumenetelmänä käytetään mobiilioppimista ja oppilaiden omia mobiililaitteita. Tutkimus teht…
Offshore Assets in the Transition from ‘Traditional Business Practice’ to ‘Connected Business Eco-systems’
2020
In many industrial sectors we have already begun to see how new business ecosystems gradually emerge turning the traditional business practices upside down. Particularly within relatively conventional sectors, such as upstream oil and gas (O&G) and land-based process industry, we expect to see substantial changes in the years to come. In this paper, we elaborate on principal challenges related to major structural changes and core technology platforms for the oil industry identifying critical features and elaborating on emerging operational principles. This is based on a critical review of latest industry conditions and practices that are targeted towards the creation of new business models …
Similarities between Playing World of Warcraft and CLIL
2012
This article argues that playing World of Warcraft (WoW) and Content and Language Integrated Learning (CLIL) have a number of similar features. We base our argument on findings from three studies. The first (Sylvén 2004/2010) is about CLIL and non-CLIL students at upper secondary level and aims to investigate what effect, if any, CLIL has on the incidental acquisition of vocabulary. The second (Sundqvist 2009) is about extramural English and aims to examine its potential impact on learners’ oral proficiency and vocabulary. Extramural English is broadly defined as any type of contact that learners have with English outside the classroom. The third is a joint study focusing on young learners …
CRiSPy-CUDA: Computing Species Richness in 16S rRNA Pyrosequencing Datasets with CUDA
2011
Pyrosequencing technologies are frequently used for sequencing the 16S rRNA marker gene for metagenomic studies of microbial communities. Computing a pairwise genetic distance matrix from the produced reads is an important but highly time consuming task. In this paper, we present a parallelized tool (called CRiSPy) for scalable pairwise genetic distance matrix computation and clustering that is based on the processing pipeline of the popular ESPRIT software package. To achieve high computational efficiency, we have designed massively parallel CUDA algorithms for pairwise k-mer distance and pairwise genetic distance computation. We have also implemented a memory-efficient sparse matrix clust…
Submarine canyon morphologies in the Gulf of Palermo (Southern Tyrrhenian Sea) and possible implications for geo-hazard
2011
12 pages, 12 figures, 1 table.
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
2012
The formation of central nervous system myelin by oligodendrocytes requires sterol synthesis and is associated with a significant enrichment of cholesterol in the myelin membrane. However, it is unknown how oligodendrocytes concentrate cholesterol above the level found in nonmyelin membranes. Here, we demonstrate a critical role for proteolipids in cholesterol accumulation. Mice lacking the most abundant myelin protein, proteolipid protein (PLP), are fully myelinated, but PLP-deficient myelin exhibits a reduced cholesterol content. We therefore hypothesized that "high cholesterol" is not essential in the myelin sheath itself but is required for an earlier step of myelin biogenesis that is f…
Norwegian children's acquisition of the dialect feature r
2019
The pronunciation of r is a central dialect feature of Norwegian. The main division is between a front and a back pronunciation. The back realization is acquired relatively early (around age 4), while the front realization is one of the most problematic sounds to acquire, and substitution sounds are frequent. Using two data collection points, we show how four children learning Norwegian start by substituting r use of the r of their dialect area or idiolectal surroundings. The main argument of this article is that the r-development of kindergarten children is not only governed by rules on acquisition and development lines, but also by the sociolinguistic variation and use of r in the Norwegi…