Search results for "peripheral"

Maxillary peripheral keratocystic odontogenic tumor. A clinical case report

2017

The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence. This neoplasia is predominantly found in males and people of white origin. The mandible is the most frequently involved site, in particular the third molar region, mandibular angle, and ramus. It has a mandible-maxilla ratio of 2:1. Only about twenty cases of peripheral keratocystic odontogenic tumors (PKCOT) have been reported in the international literature. This study presents a case of PKCOT localized in the anterior region of the maxilla…

Binding Sites for Neurotoxins and Cholinergic Ligands in Peripheral and Neuronal Nicotinic Receptors Studies with Synthetic Receptor Sequencesa

1995

Molecular polymorphism of the ABO blood group: A study in Poland, Spain, and Andorra

2014

Objectives The main goal of this study is to increase knowledge on the molecular level of the ABO blood group system in Europe by providing data for Poland, Spain, and Andorra populations. Methods A total of 172 oral scrapings samples from individuals of Polish origin, 108 peripheral blood samples of autochthonous individuals from the province of Zamora (Spain), and 81 peripheral blood samples from individuals with Andorran origin, were analyzed. Molecular characterization of the allelic variants was performed by the analysis of exons 6 and 7 of the ABO gene. Results Seven common alleles were identified, namely: A101, A102, A201, B101, O01, O02, and O03. Less common variants (O05, O09, O21,…

Principle considerations for the use of transcriptomics in doping research

2011

Over the course of the past decade, technical progress has enabled scientists to investigate genome-wide RNA ex- pression using microarray platforms. This transcriptomic approach represents a promising tool for the discovery of basic gene expression patterns and for identification of cellular signalling pathways under various conditions. Since doping substances have been shown to influence mRNA expression, it has been suggested that these changes can be detected by screening the blood transcriptome. In this review, we critically discuss the potential but also the pitfalls of this application as a tool in doping research. Transcriptomic approaches were considered to potentially provide resea…

The monocyte-macrophage system is affected in lysosomal storage diseases: an immunoelectron microscopic study

1997

Studying peripheral blood mononuclear cells (PBMCs) has become an important diagnostic tool in lysosomal storage diseases. Previous studies revealed that B and subclasses of T lymphocytes participate in the storage process, whereas the role of circulating monocytes was not clear. In this study, the involvement of CD14+ monocytes in lysosomal diseases was investigated. Blood samples from six patients with different lysosomal storage disorders were studied, including one with late--infantile and three with juvenile neuronal ceroid--lipofuscinoses, and two with mucopolysaccharidosis type VI. CD14+ cells were separated immunomagnetically from PBMCs and studied by light and electron microscopy. …

Perception of Biological Motion in Central and Peripheral Visual Fields

2017

Abstract Studies analysing biological motion perception based on reduced number of dots have demonstrated that biological motion can be perceived even when only the lower part of the body is visible or when the number of dots representing the object is reduced. What is the minimal amount of information that enables biological motion to be distinguished from its scrambled version? The results of the current experiment demonstrate that biological motion can be distinguished from its scrambled version when the object is formed of approximately 5 (4.7 ± 0.1) dots. Additionally, we also investigated whether the threshold value for biological motion perception differs in central and peripheral vi…

Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia

2009

Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia Chronic low-grade inflammation with subsequent impairment of immune system function promotes the development of age-related diseases, such as cancers, degenerative and infection diseases. It is not yet clear, if exposure to ionising radiation accelerates the aging process. The aim of the present work was to estimate the production of several cytokines by peripheral blood cells of Latvia's Chernobyl clean-up workers depending on age. ELISA was employed to determine the plasma level of sIL-1β and sIL-6 as well as level of IL-4 and TNF-α spontaneous and 24h and 96h after in vitro stimulation of peripheral blood mo…

Autoimmune endocrine ophthalmopathy and retrobulbar antigens.

1995

Endocrine Ophthalmopathy (EO) is based on autoimmune processes that lead to lymphocyte infiltration of the retrobulbar space. In this study, antigenic character of retrobulbar adipose, connective and muscle tissue as well as of cultured fibroblasts and myoblasts were examined. Samples were obtained from EO patients (n = 13, 8 fem., age 26-82 years, median 47 years) undergoing orbital decompression surgery. Retrobulbar and abdominal tissue from 7 controls (4 fem., 48 - 74 y) was investigated, too. Tissues were homogenized and the proteins were separated by SDS-PAGE according to molecular weight. In order to recover the separated proteins in soluble form, an electroelution technique was emplo…

Dépendance de la fatigue à la longueur musculaire : approche mécanique et neurophysiologique

2006

The objective of this work is to evaluate the fatigue dependency on the knee extensor muscles length. Exercises varying the type of contraction (isometric and eccentric) and intensity of contraction (maximal and sub-maximal) are performed in order to disrupt the neuromuscular system by different factors of fatigue: central and peripheral. These exercises are performed at two muscular lengths (S and L, corresponding respectively to 40 and 100° of knee flexion). Neuromuscular parameters (maximal torque, muscular twitch, voluntary activation level, electromyographic activity, etc.) are analyzed in pre- and post-fatigue conditions in the type of contraction required by the fatiguing exercise. I…

Expansion of intracellular IFN-γ positive lymphocytes during Mycoplasma agalactiae infection in sheep.

2010

Abstract A method to assess the expansion of antigen-specific intracellular IFN-γ positive T cell subsets during the infection will be helpful for a better understanding of mycoplasmal infections physiopathology in the sheep. We analysed the percentage of antigen-specific lymphocytes positive for intracellular IFN-γ during the infection of sheep with Mycoplasma agalactiae by culturing peripheral blood mononuclear cells of infected or uninfected animals with irradiated M. agalactiae . The expansion of antigen-specific IFN-γ positive lymphocytes in infected sheep was initially sustained by CD4 + T cells at day 15 after infection, when antigen specific IgG start to be detectable, followed by C…