Search results for "pero"
showing 10 items of 3365 documents
Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and I…
1998
Regulation of gene expression of three putative long-chain fatty acid transport proteins, fatty acid translocase (FAT), mitochondrial aspartate aminotransferase (mAspAT), and fatty acid transport protein (FATP), by drugs that activate peroxisome proliferator-activated receptor (PPAR) alpha and gamma were studied using normal and obese mice and rat hepatoma cells. FAT mRNA was induced in liver and intestine of normal mice and in hepatoma cells to various extents only by PPARalpha-activating drugs. FATP mRNA was similarly induced in liver, but to a lesser extent in intestine. The induction time course in the liver was slower for FAT and FATP mRNA than that of an mRNA encoding a peroxisomal en…
Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver dise…
2015
Scope Flavonoids and related compounds seem to have favorable effects on nonalcoholic fatty liver disease (NAFLD) progression, although the exact mechanisms implicated are poorly understood. In this study, we aimed to investigate the effect of the flanovol quercetin on gene expression deregulation involved in the development of NAFLD, as well as the possible implication of phosphatidylinositol 3-kinase (PI3K)/AKT pathway modulation. Methods and results We used an in vivo model based on methionine- and choline-deficient (MCD) diet-fed mice and an in vitro model consisting of Huh7 cells incubated with MCD medium. MCD-fed mice showed classical pathophysiological characteristics of nonalcoholic…
Assessment of local cellular immunity in lung cancer by bronchoalveolar lavage.
1990
Small cell lung cancer (SCLC) is the most malignant of the pulmonary neoplasms and is associated with a poor local cellular immune response. 16 patients with non small cell lung cancer (NSCLC) and 11 patients with SCLC underwent bronchoalveolar lavage (BAL) in the lung which harbored the tumor in order to investigate the lymphocyte surface antigens utilizing the immunoperoxidase technique. Analysis of blood lymphocytes was performed in parallel. 8 patients with previous sarcoidosis in complete remission who underwent BAL and 10 normal blood donors served as controls. Among blood lymphocytes the CD3+, CD4+ and CD16+ cell populations were elevated significantly and the T4/T8 ratio was elevate…
Docosahexaenoic acid modulates the expression of T-bet and GATA-3 transcription factors, independently of PPARα, through suppression of MAP kinase ac…
2009
The present study was conducted on CD4(+) T cells, isolated from wild type (WT) and PPARalpha(null) mice, in order to assess the mechanism of action of docosahexaenoic acid (DHA), an n-3 fatty acid, in the modulation of two transcription factors, i.e., T-bet and GATA-3, implicated in T-cell differentiation towards, respectively, T(H)1 and T(H)2 phenotype. The T-cells from PPARalpha(null) mice secreted higher IFN-gamma and lower IL-4 concentrations than WT T-cells. Furthermore, the deletion of PPARalpha gene in T-cells resulted in the upregulation of T-bet and downregulation of GATA-3 both at mRNA and protein levels. DHA exerted not only an inhibitory effect on T-cell proliferation, but also…
Prospero hierae (Hyacinthaceae), a New Species from Marettimo Island (Sicily)
2009
A new species, Prospero hierae C. Brullo, S. Brullo, Giusso, Pavone & Salmeri (Hyacinthaceae), from Island of Marettimo (Egadi Archipelago, Sicily) is described and illustrated. Its chromosome number (2n = 14), leaf anatomy and ecology are examined. This small species with glaucous, adaxially flat leaves is closely related with the taxa belonging to the Prospero autumnale group and, in particular, it shows more affinities with P. corsicum, P. pulchellum and P. minimum.
Litija sāļu – imidazolija jonu šķidrumu elektrolītu jonu vadītspēja un termiskā stabilitāte
2016
Litija sāļu - imidazolija jonu šķidrumu elektrolītu jonu vadītspēja un termiskā stabilitāte Singatulovs J., zinātniskais vadītājs Dr. chem., doc. Vaivars G. bakalura darbs, 38 lappuses, 21 attēli, 25 literatūras avoti. Latviešu valodā. Darbā tika sintezēti divi jonu šķidrumi: 1-butil-3-metilimidazolija dimetilfosfāts un 1,3-dimetilimidazolija dimetilfosfāts. Vadītspēja un elektroķīmiskā stabilitāte atkarībā no temperatūras tika noteiktas tīriem jonu šķidrumiem un jonu šķidrumu - litija nitrāta elektrolītiem. Tika izstrādāta vadītspējas atkarības no temperatūras noteikšanas metodika. Ar impedances spektroskopiju tika noteikti vadītspēju ietekmējoši faktori.
CULTURE CITIES
2008
Il volume approfondisce le metodologie e le tecnologie per la realizzazione dei distretti culturali. La valorizzazione dei distretti culturali è finalizzata alla creazione di un ambiente favorevole al mantenimento e all’attrazione di attività economiche compatibili e a basso impatto ambientale (e-business) e alla diffusione della conoscenza del territorio e delle sue valenze (e-tourism). Il volume è dunque il risultato di una sperimentazione attiva sul territorio, in cui si elaborano le linee guida per il risanamento delle aree degradate ed il recupero delle cortine storiche dell’area di Piazza Garraffello (l’antico mercato della Vucciria) a Palermo Il volume è il risultato della ricerca CI…
Roflumilast N-oxide combined with PI3Kδ inhibitor improves the phenotype of early-onset COPD
2016
Background: Severe, early-onset COPD (Chronic Obstructive Pulmonary Disease) is characterized by a rapid decline in lung function at an early age with neutrophil over-activation. Roflumilast is approved as treatment for moderate and severe COPD at risk of exacerbation as add on therapy. Recent evidence indicates that the combination of PDE4 and PI3Kδ inhibitors show synergic anti-inflammatory properties. Objectives: To explore the effects from adding a selective PI3Kδ inhibitor to roflumilast N-oxide (RNO) in neutrophils isolated from peripheral blood of severe, early-onset COPD patients in in vitro models. Methods: Neutrophils were isolated from peripheral blood of 20 severe, early-onset C…
La vaccinazione antinfluenzale come Strumento di Sanità pubblica e di prevenzione. Esperienza dell'Azienda Ospedaliero Universitaria Policlinico (AOU…
2009
Introduzione Le Linee guida per la prevenzione e controllo dell'influenza, emanano Ogni anno dal Ministero della Salute, raccomandano la vaccinazione per tutti Coloro Che svolgono Funzioni lavorative di primario interesse collettivo. Il personale sanitario rappresenta, un tal Riguardo, un obiettivo strategico della campagna da vaccino antinfluenzale SIA per la possibile trasmissione dell'influenza aviaria Pazienti SIA Perchè l'eventuale assenteismo Potrebbe inficiare la qualità e la Capacità dell'Assistenza erogata. La trasmissione dell'influenza ad un Paziente è sicuramente un importante Rischio nosocomiale in Quanto l'Infezione virale PUÒ portare ad un aggravamento dello stato di salute d…
The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis
2015
IBD is a chronic disorder of the gastrointestinal tract characterized by mucosal inflammation and epithelial damage. Biologic therapy has significantly improved the course of the disease but there are still a high percentage of patients that do not respond to current therapies. We aim to determine the effects of the flesh ethanolic extract of Hylocereus polyrhizus (EH) in a mice model of colitis induced by TNBS.Balb/c mice received TNBS (175 mg/kg, 100 μl, i.r.) and six and thirty hours later were administered with EH (1 g/kg, i.p.). Mice were weighted daily and after sacrificing (2 and 4 days after TNBS) we analyzed mucosal histology, myeloperoxidase activity (MPO), the expression of pro-i…