Search results for "personalized"
showing 10 items of 165 documents
Defining new biotypes in Prostate Cancer for diagnosis, prognosis and therapeutic intervention
2015
El cáncer de próstata (CaP) es el segundo tumor más frecuente en hombres y la sexta causa de muerte por cáncer. Así pues, esta enfermedad constituye un problema socio-sanitario prioritario para el sistema de Salud Pública. Actualmente, las herramientas para orientar el diagnóstico en CaP (PSA y DRE) no son cáncer específicas y presentan distintas limitaciones tales como el alto número de falsos positivos (aproximadamente un 70% en un rango de PSA de 4-10 ng/ml) que dan lugar a complicaciones asociadas con el proceso de biopsia. Además, un gran número de los CaP diagnosticados son tumores de bajo grado implicando un sobre-diagnóstico y sobre-tratamiento de esta enfermedad. Sin embargo, otros…
Drawing the premises for personalized learning : illustrations of management and accounting
2019
This paper reports on a teaching innovation using participant-generated drawings. Experienced managers were asked to produce a drawing to illustrate their work from an accounting perspective. The drawings were then used to make the managerial context of the participants the explicit starting point for personalized executive learning. This study is the first in the sphere of accounting education and research to take drawing seriously as a learning method. The results of the experiment show how drawing can be further used as a tool in management education by facilitating the visualization of the managerial contexts participants work within. peerReviewed
Esperienze di didattica personalizzata
2019
Con l’educazione personalizzata si cerca di aiutare ogni studente a valorizzare ciò in cui è differente rispetto agli altri, le proprie possibilità e i propri limiti; a conoscersi e a coltivare la propria originalità. Obiettivo che risulta perseguibile lavorando sul fronte della formazione degli insegnanti – perfezionandone le conoscenze disciplinari e interdisciplinari e la metodologia d’insegnamento delle discipline in tutti i gradi della scuola – e sull’orientamento degli alunni e delle alunne attraverso la progettazione e l’implementazione di percorsi di apprendimento ad hoc. With personalized education we try to help each student to value what it is different from others, its possibili…
Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
2015
We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only broadens the diversity of TCRs suitable for clinical use, but also sets the stage for actively personalized immunotherapeutic strategies.
On personalized adaptation of learning environments
2017
This work is devoted to the development of personalized training systems. A major problem in learning environments is applying the same approach to all students: i.e., teaching materials, time for their mastering, and a training program that is designed in the same way for everyone. Although, each student is individual, has his own skills, ability to assimilate the material, his preferences and other. Recently, recommendation systems, of which the system of personalized learning is a part, have become widespread in the learning environments. On the one hand, this shift is due to mathematical approaches, such as machine learning and data mining, that are used in such systems while, on the ot…
Molecular Pathways Implicated in Radioresistance of Glioblastoma Multiforme: What Is the Role of Extracellular Vesicles?
2023
Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to treatment, and characterized by a high degree of anaplasia and proliferation. Routine treatment includes ablative surgery, chemotherapy, and radiotherapy. However, GMB rapidly relapses and develops radioresistance. Here, we briefly review the mechanisms underpinning radioresistance and discuss research to stop it and install anti-tumor defenses. Factors that participate in radioresistance are varied and include stem cells, tumor heterogeneity, tumor microenvironment, hypoxia, metabolic reprogramming, the chaperone system, non-coding RNAs, DNA repair, and extracellular vesicles (EVs). We direct our a…
Air Pollution: Role of Extracellular Vesicles-Derived Non-Coding RNAs in Environmental Stress Response
2023
Air pollution has increased over the years, causing a negative impact on society due to the many health-related problems it can contribute to. Although the type and extent of air pollutants are known, the molecular mechanisms underlying the induction of negative effects on the human body remain unclear. Emerging evidence suggests the crucial involvement of different molecular mediators in inflammation and oxidative stress in air pollution-induced disorders. Among these, non-coding RNAs (ncRNAs) carried by extracellular vesicles (EVs) may play an essential role in gene regulation of the cell stress response in pollutant-induced multiorgan disorders. This review highlights EV-transported ncRN…
Current advancement in immunosensing of p53 tumor suppressor protein based on nanomaterials: Analytical approach
2017
Abstract The utility of detection of p53 in tomorrow's personalized health care field will mean early and accurate diagnosis of many types of cancers. This review is meant to provide an overview of the various types of immunosensors and immunoassay have been developed for determination of p53, along with significant advances over the last several years in related technologies. In addition, this review described: • Most frequently applied principles in immunoassay/immunosensing of p53. • The aspects of fabrication in the perspective of immunoassay/immunosensing applications. • The potential of various electrochemical, electrochemiluminescence immunosensors for the determination of p53 within…
Utilizing nutritional genomics to tailor diets for the prevention of cardiovascular disease: a guide for upcoming studies and implementations.
2017
Introduction: Personalized diets based on an individual’s genome to optimize the success of dietary intervention and reduce genetic cardiovascular disease (CVD) risk, is one of the challenges most frequently discussed in the scientific community. Areas covered: The authors gathered literature-based evidence on nutritional genomics and CVD phenotypes, our own results and research experience to provide a critical overview of the current situation of using nutritional genomics to tailor diets for CVD prevention and to propose guidelines for future studies and implementations. Expert commentary: Hundreds of studies on gene-diet interactions determining CVD intermediate (plasma lipids, hypertens…
Biomarkers in reproductive medicine: the quest for new answers.
2015
Personalized medicine in assisted reproductive technologies (ART) is still in its infancy. Precision medicine, based on objective molecular tools added, to clinical medicine is well-accepted and developed in oncology and other potent medical disciplines. The impact of personalized medicine in cancer is broad, from screening to diagnosis, with the stratification of patients into cancer subgroup categories, facilitating individualized therapies that impact treatment effectiveness and disease recurrence (Diamandis et al., 2010; Hamburg and Collins, 2010). In reproductive medicine many ‘unknown black boxes’ still exist. These will only be unraveled with the timely application of novel technolog…