Search results for "pharmaceutical"
showing 10 items of 3243 documents
Occurrence of pharmaceuticals in municipal wastewater treatment plants and receiving surface waters in Central and Southern Finland
2016
The presence of five selected pharmaceuticals, four anti-inflammatory drugs, diclofenac, ibuprofen, ketoprofen, naproxen, and an antiepileptic drug carbamazepine, was determined at four municipal wastewater treatment plants (WWTPs) and in the receiving waterway near the city of Jyväskylä, in central Finland and also in the River Vantaa. First, an analytical method was developed including a pretreatment and purification followed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in the multiple reaction monitoring mode. The studied pharmaceuticals were detected from influents and effluents of four municipal WWTPs and from surface water of eight locations along the water …
N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
2015
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cel…
Angular Regioselectivity in the Reactions of 2-Thioxopyrimidin-4-ones and Hydrazonoyl Chlorides : Synthesis of Novel Stereoisomeric Octahydro[1,2,4]t…
2020
The regioselective synthesis of cis and trans stereoisomers of variously functionalized octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones was performed. The 2-thioxopyrimidin-4-ones used in the synthesis reacted with hydrazonoyl chlorides in a regioselective manner to produce the angular regioisomers [1,2,4]triazolo[4,3-a]quinazolin-5-ones rather than the linear isomers [1,2,4]triazolo[4,3-a]quinazolin-5-ones. The synthesis process took place with electronic control. The angular regiochemistry of the products was confirmed by X-ray experiments and two-dimensional NMR studies.
Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (…
2022
Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid or neat acetic acid to afford a novel pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved to be efficient, with a shorter reaction time and high chemical yield with broad substrates. The new pyrazolyl-s-triazine derivatives were tested against the following cell lines: MCF-7 (breast cancer); MDA-MB-231 (tr…
Sustainability in the restoration and management of the historic architecture in Palermo
2015
This research investigates the energy and environmental sustainability in the restoration and conservation of historic buildings. It focuses on the architectural heritage of Palermo, which can be a significant case study for the Mediterranean area. Its objective is to analyse the current energy performance of this historic architecture and its potential for energy improvement. Therefore, it aims at proposing a methodology to combine the enhancement of energy and environmental performances of the historic architecture of Palermo with the need of its material and aesthetic conservation, in the frame of the current regulations.
Rebuilt the space using stone or brick vaulted systems: catching the contemporary challenge of construction tradition
2019
In the recovery and restoration sites, as well as in the versatile word of university research about construction history, its not infrequent to study stereotomy for the re-proposal of stony or tiled vaulted systems, sometimes complex for their constitutive geometry, equipment, preliminary/subsidiary carpentry works. It represents a didactic study-key also in Engineering and Architecture Schools, through laboratories that teach to future designers a know-how that can be easily spent in their professional repercussions.
Innovative, Translucent and Multi-functional Components for the Building Envelope: technological and performance optimization
2017
The paper describes the actions aimed at the technology and performance optimization of an innovative, multi-functional building component made of precast and pre-stressed glass blocks useful for the construction of sustainable building envelopes able to reduce the energy consumption and to produce clean energy from the sun. The design optimization of different sub-components and the choice of the right materials for guaranteeing their good response in terms of mechanical resistance, thermal and acoustic insulation, light transmission, electricity production, integration with other components, dimensional coordination, are particularly described.
Architecture in iron in the city of XIX century Roof structures of theatres and covered markets in Palermo
2016
In post-unification Palermo, components manufactured abroad were usually used for complementary iron structures (greenhouses and skylights, projecting roofs, staircases…), whereas, for more demanding works, more weight was given to the contribution of producers with experience gained in the field of metal construction. Analysis is here carried out on the works of greatest importance, from the roofs of the two major theatres to the roofing of food market structures; the finest technicians were employed and a critical debate was triggered in the city with regard to formal, static and building aspects.
Strategies, Technologies and Novel Components for the Architectural Integration of Photovoltaics
2015
La ricerca riguarda l'integrazione architettonica del fotovoltaico (FV) per il retrofit energetico del patrimonio edilizio esistente e la costruzione di edifici a energia zero (ZEB). L'obiettivo è lo studio e la successiva definizione di strategie, tecnologie e componenti innovativi per l'involucro edilizio che integrino il fotovoltaico, con particolare attenzione verso le tecnologie fotovoltaiche di nuova generazione. Il lavoro si concentra anche sull'ottimizzazione energetica e sull'analisi delle prestazioni di un componente innovativo per il BIPV (Building Integrated Photovoltaics, letteralmente fotovoltaico integrato negli edifici) utile alla costruzione di involucri edilizi sostenibili…
The assessment of the reliability of an innovative 3rd generation solar cell integrated with “thermal belt” glass block
2017
Glass block is a building product widely used for the construction of translucent building façades and roofs. The need to adapt the product to the regulations in the field of energy saving and environmental sustainability has led to the design of innovative configurations, through the integration of different sub-components. These ones are able to improve its energy performance by means of the integration of a“thermal belt”, cold glued to the glass shells, which constitute the traditional glass block, and 3rd generation solar cells. This paper reports the first results of the experimental program designed to assess some durability components: inherent and critical reliability. <div id="g…