Search results for "physiologic"

Adaptation and ecological speciation in seasonally varying environments at high latitudes: Drosophila virilis group

2022

Living in high latitudes and altitudes sets specific requirements on species’ ability to forecast seasonal changes and to respond to them in an appropriate way. Adaptation into diverse environmental conditions can also lead to ecological speciation through habitat isolation or by inducing changes in traits that influence assortative mating. In this review, we explain how the unique time-measuring systems of Drosophila virilis group species have enabled the species to occupy high latitudes and how the traits involved in species reproduction and survival exhibit strong linkage with latitudinally varying photoperiodic and climatic conditions. We also describe variation in reproductive barriers…

Some morphological, anatomical, physiological responses of different olive cultivars to high temperatures and drought stress

2004

The aim of this work is to find relationships between morphology and physiology in three different olive cultivars: Biancolilla, Cerasuola and Nocellara del Belice, when plants were subjected to high temperature and drought. These cultivars are estensively used in Sicily for productive purposes. The results about ultrastructural and physiological studies on shoot growth, leaf anatomy, chloroplast ultrastructure and oxygen production, indicate that Biancolilla is the cultivar in which the studied traits showed fewer changes and can be considered to have the best tolerance to both high temperatures and water deficit. In the other hand, the morphological and physiological characteristics studi…

Theme issue 5th World Conference on Drug Absorption, Transport and Delivery.

2014

A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokine…

2019

Abstract Background and objective The aims of this study are (i) to assess the predictive reliability of the physiologically based software PhysPK versus the well-known population approach software NONMEM for the cited semi-mechanistic PK model, (ii) to determine whether these modelling approaches are interchangeable and (iii) to compare acausal with causal modelling approaches in the framework of semi-mechanistic PK models. Methods A semi-mechanistic model was proposed, which assumed oral administration of a solid dosage form with a peripheral compartment and two active metabolites. The model incorporates intestinal transit, dissolution limited by solubility, variable efflux transporter ex…

Drugs and the Colon

1983

It is not our intention to review drug effects in the colon, which was done extensively and profoundly by Forth and Rummel1 and Powell.2 Our contribution will present studies of drug effects on physiological absorption and secretion processes obtained in the intact human colon and based on results of intestinal perfusion studies of the whole colon and measurements of transepithelial electrical potential difference (PD) in the rectosigmoid colon. These are at present the practiced and—regarding perfusion studies—most accurate techniques in the hands of clinicians to directly study drug effects on a local dose-response scale in the intact human colon. Since these methods are relatively new an…

Pharmacology of Acamprosate: An Overview

2003

In the last years important advances have been made in the development of drugs for the treatment of alcohol addiction. Acamprosate (calcium bis‐acetylhomotaurine) is one of the better established drugs in this field on the European market. This review focuses first on the pharmacokinetics of acamprosate. The published data and the recent advances in our knowledge on the mechanisms involved in the intestinal absorption and elimination of this drug are summarized. The importance of pharmacokinetics for the proper clinical use of acamprosate is highlighted. The anti‐relapse as well as the well‐known effects of acamprosate on ethanol intake are discussed. The recent experiments in animal model…

Mildronate: An Antiischemic Drug for Neurological Indications

2005

Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronate is efficient in the treatment of heart ischemia and its consequences. Extensive evaluation of pharmacological activities of mildronate revealed its beneficial effect on cerebral circulation disorders and central nervous system (CNS) functions. The drug is used in neurological clinics for the trea…

Pre-Clinical Studies with D-Penicillamine as a Novel Pharmacological Strategy to Treat Alcoholism: Updated Evidences

2017

Ethanol, as other drugs of abuse, is able to activate the ventral tegmental area dopamine (VTA-DA) neurons leading to positively motivational alcohol-seeking behavior and use, and, ultimately to ethanol addiction. In the last decades, the involvement of brain-derived acetaldehyde (ACD) in the ethanol actions in the mesolimbic pathway has been widely demonstrated. Consistent published results have provided a mechanistic support to the use of ACD inactivating agents to block the motivational and reinforcing properties of ethanol. Hence, in the last years, several pre-clinical studies have been performed in order to analyze the effects of the sequestering ACD agents in the prevention of ethano…

Feasibility of Linear Parametric Estimation of Dynamic Information Measures to assess Physiological Stress from Short-Term Cardiovascular Variability

2021

Extensive efforts have been recently devoted to implement fast and reliable algorithms capable of assessing the physiological response of the organism to physiological stress. In this study, we propose the comparison between model-free and linear parametric methods as regards their ability to detect alterations in the dynamics and in the complexity of cardiovascular and respiratory variability evoked by postural and mental stress. Dynamic entropy (DE) and information storage (IS) measures were calculated on three physiological time-series, i.e. heart period, respiratory volume and systolic arterial pressure, on 61 healthy subjects monitored in resting conditions as well as during head-up ti…

Revisiting the left convexity hypothesis: changes in the mental apparatus after left dorso-medial prefrontal damage

2016

It has been 15 years since Kaplan-Solms and Solms published their Clinical Studies in Neuropsychoanalysis, where they proposed a neuroanatomy of the mental apparatus. One of their main observations was that damage to certain areas of the left prefrontal cortex (PFC), particularly those related to expressive language (Broca’s area), did not generate changes in the mental apparatus. However, a limitation of their model was that it did not include patients with damage to other areas of the left PFC. The main goal of this paper is to update Kaplan-Solms and Solms’ model through the description of id, ego and superego changes in a case of left dorso-medial prefrontal damage (Professor F). Data f…