Search results for "physiologic"

Pain Phenotypes in Rare Musculoskeletal and Neuromuscular Diseases

2020

For patients diagnosed with a rare musculoskeletal or neuromuscular disease, pain may transition from acute to chronic; the latter yielding additional challenges for both patients and care providers. We assessed the present understanding of pain across a set of ten rare, noninfectious, noncancerous disorders; Osteogenesis Imperfecta, Ehlers-Danlos Syndrome, Achondroplasia, Fibrodysplasia Ossificans Progressiva, Fibrous Dysplasia/McCune-Albright Syndrome, Complex Regional Pain Syndrome, Duchenne Muscular Dystrophy, Infantile- and Late-Onset Pompe disease, Charcot-Marie-Tooth Disease, and Amyotrophic Lateral Sclerosis. Through the integration of natural history, cross-sectional, retrospective…

Bandwidth Resource Management for Neural Signal Telemetry

2009

Recent advances in modern neurocomputing have shown the utmost necessity of wireless communication systems that allow real-time (RT) monitoring of neural signals meeting several requirements such as source compression and high fidelity of the received signal. Neural recordings require multielectrode probes with up to hundreds of electrodes and transmission of signals wirelessly over a limited bandwidth (BW). In this paper, a RT resource management algorithm is proposed so that adequate source compression is applied to each channel in order to fit them into the available BW. Performance of the algorithm is analyzed using dynamically changing BW and neural recordings with different neural act…

Neuronal populations mediating the effects of endocannabinoids on stress and emotionality

2011

An adequate emotional response to stress is essential for survival and requires the fine-tuned regulation of several distinct neuronal circuits. Therefore, a precise control of these circuits is necessary to prevent behavioral imbalances. During the last decade, numerous investigations have evidenced that the endocannabinoid (eCB) system is able to crucially control stress coping. Its central component, the cannabinoid type 1 receptor (CB1 receptor), is located at the presynapse, where it is able to attenuate neurotransmitter release after its activation by postsynaptically produced and released eCBs. To date, the eCB system has been found to control the neurotransmitter release from severa…

Cycle-triggered averaging of respiration-related neuronal activity

1985

Abstract A computer system is presented which provides off-line computation of cycle-triggered histograms (CTH) of respiration-related neuronal activity. Binwidths of the histograms are freely selectable by software from 10 ms to 100 ms. For special evaluation purposes. CTHs can be standardized in different ways concerning cycle duration as well as amplitude. Time incidence of maximum frequency, center of gravity and expiration-to-inspiration phase transition within the respiratory cycle are computed. The system employs special hardware interfaces to an 8-bit microcomputer which are briefly described. Data acquisition, data manipulation and output handling of the results are performed by ch…

Nucleus incertus—An emerging modulatory role in arousal, stress and memory

2011

A major challenge in systems neuroscience is to determine the underlying neural circuitry and associated neurotransmitters and receptors involved in psychiatric disorders, such as anxiety and depression. A focus of many of these studies has been specific brainstem nuclei that modulate levels of arousal via their ascending monoaminergic projections (e.g. the serotonergic dorsal raphe, noradrenergic locus ceruleus and cholinergic laterodorsal tegmental nucleus). After years of relative neglect, the subject of recent studies in this context has been the GABAergic nucleus incertus,1 which is located in the midline periventricular central gray in the ‘prepontine’ hindbrain, with broad projection…

A module for syntactic processing in music?

2006

Music and language have rules governing the structural organization of events. By analogy to language, these rules are referred to as the ‘syntactic rules’ of music. Does this analogy imply that the brain actually performs syntactic computations on musical structures, similar to those for language and based on a specialized module [1–3]? In contrast to linguistic syntax, which involves abstract computation between words, rules governing musical syntax are rooted in psychoacoustic properties of sound: syntactically related events are related on a sensory level and involve only weak acoustical deviance.

Time Hurries on but Does not Fly in Older Age — No Effect of Depressive Symptoms

2021

Abstract Research on the commonly known phenomenon of perceived accelerated time passage with increasing age has provided inconsistent results. This could be due to a mediating time-slowing effect of depressive symptoms as the prevalence of depression does also alter with age. Based on a large sample of 380 subjects covering a continuous range of age between 20 and 70 years, we tested whether the assumed age-related effect on time perception is being mediated by symptoms of depression. Cross-sectional differences indicate a weak, but significant nonlinear acceleration of the perceived passage of time especially during mid-adulthood, whereas no further alteration was observed above the age o…

Heart rate accelerations during four active encoding tasks — pilot results

1997

Comorbidity and developmental neurocognitive disorders

1995

On the current neuroenhancement use of transcranial direct current stimulation by healthy individuals—A non-fictional snap-shot: Commentary on Lapent…

2014

This commentary examines the pros and cons of the fictitious enhancement scenarios used in Lapenta et al. 2014. Then it gives a non-fictional impression of the current self-enhancement use of transcranial direct current stimulation (tDCS) by healthy individuals and discusses the ethical issues involved.