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showing 10 items of 8215 documents
Translating recent results from the Cardiovascular Outcomes Trials into clinical practice: recommendations from the Central and Eastern European Diab…
2017
Aims These recommendations aim to improve care for patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk in Central and Eastern Europe. Cardiovascular disease (CVD) and/or chronic kidney disease (CKD) are major interdependent comorbidities in patients with T2D, accounting for 50% of mortality. Following recent CV outcomes trial (CVOT) results, including those from EMPA-REG OUTCOME®, LEADER®, SUSTAIN™-6 and, most recently, the CANVAS study, it is essential to develop regional expert consensus recommendations to aid physicians in interpreting these newest data to clinical practice. Methods The Central and Eastern European Diabetes Expert Group (CEEDEG) followed a Delphi method …
Effect of using cardiovascular risk scoring in routine risk assessment in primary prevention of cardiovascular disease: an overview of systematic rev…
2019
Background Our objectives were to critically appraise and summarise the current evidence for the effectiveness of using cardiovascular disease (CVD) risk scoring (total risk assessment - TRA) in routine risk assessment in primary prevention of CVD compared with standard care with regards to patients outcomes, clinical risk factor levels, medication prescribing, and adverse effects. Methods We carried out an overview of existing systematic reviews (SRs). Presentation of the results aligned guidelines from the PRISMA statement. The data is presented as a narrative synthesis. We searched MEDLINE (Ovid), EMBASE, CENTRAL and SCOPUS databases from January 1990 to March 2017, reviewed the referenc…
Pain neuroscience education and physical exercise for patients with chronic spinal pain in primary healthcare: a randomised trial protocol.
2019
AbstractBackgroundChronic musculoskeletal pain affects more than 20% of the population, and the prevalence is increasing, causing suffering, loss of quality of life, disability, and an enormous expenditure on healthcare resources. The most common location for chronic pain is the spine. Many of the treatments used are mainly passive (pharmacological and invasive) and poor outcomes. The treatments currently applied in the public health system do not comply with the recommendations of the main clinical practice guidelines, which suggest the use of educational measures and physical exercise as the first-line treatment. A protocol based on active coping strategies is described, which will be eva…
Geographic Information System of Primary Carbon Deposit of Mangrove Forest in Merauke District, Indonesia
2020
Emission factors with increasing carbon dioxide (CO2) originating from various human activities are one of the causes of global climate change. The mangrove forest is a type of plant that has a great ability to absorb carbon in the atmosphere and store it in biomass through photosynthesis. Merauke Regency has 20 separate parts based on regional administration, but primary Mangrove forests are only found in ten regions (district). The results of research carried out using geographic information systems (GIS) in processing primary Mangrove forest data based on 2016 land cover map data in Merauke district, the area of primary mangrove forest reaches 184.402 ha, which is spread in various regio…
Vitamin D, allergies and asthma: focus on pediatric patients
2014
In recent years, the interest of the scientific world towards vitamin D gradually increased, and several studies have been conducted to dissect its possible role in modulating the development/course of allergic diseases. Also, Vitamin D supplementation has been assessed as a beneficial approach for treating allergies in some, but not all studies. We reviewed herein the available and relevant literature concerning the possible links between Vitamin D, its supplementation and allergic diseases. A literature search was made independently by the Authors, identifying articles for a narrative review. As per literature, Vitamin D plays a key role in calcium and phosphate metabolism, and it is esse…
Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epitope immunogenicity, here we propose a supervised machine learning framework generating probabilistic estimates of immunogenicity, termed "immunogenicity scores," based on the numerical features computed through sequence-based simulation approximating the molecular scanning process of peptides presented onto major histocompatibility complex (MHC) by the human T cell receptor (T…
Blood Transfusion Management for Patients Treated With Anti-CD38 Monoclonal Antibodies
2018
Daratumumab has proven to be highly efficacious for relapsed and refractory multiple myeloma (MM) and has recently been approved in the frontline setting for MM patients ineligible for transplantation. In the future, expanded indications are possible for daratumumab and other anti-CD38 monoclonal antibodies in development. For several years, it has been recognized that these therapies interfere with blood bank testing by binding to CD38 on red blood cells and causing panagglutination on the Indirect Antiglobulin Test. This can lead to redundant testing and significant delays in patient care. Given the anticipated increase in utilization of anti-CD38 monoclonal antibodies, as well as the tra…
la serrata e le altre forme di lotta sindacale
2011
Sommario: 1. Premessa: definizione della serrata e tipologie. – 2. Il dato normativo: il silenzio della Costituzione e la sentenza della Corte Costituzionale n. 29/1960. - 3. La rilevanza penale della serrata. – 4. La rilevanza civile della serrata “per fini contrattuali”. – 5. La serrata di ritorsione. - 6. La serrata di reazione come comportamento antisindacale. - 7. Le altre forme di lotta sindacale. – 8. Il picchettaggio. – 9. L’occupazione d’azienda. – 10. Il boicottaggio e il sabotaggio.
New Italian Epic versión 2.0. Memorándum 1993-2008: narrativa, mirada oblicua, vuelta al futuro.
2015
La Nueva Épica Italiana (New Italian Epic o, más comúnmente, NIE) es una denominación propuesta por el escritor Wu Ming 1 para abarcar una serie de obras literarias escritas en Italia por diversos autores en las últimas dos décadas y que comparten unos mismos presupuestos. Tal corpus de libros, en su mayoría novelas de notable contenido histórico, tendrían en común tanto constantes estilísticas como temática, además de rasgos comunes como pueden ser la intención alegórica de fondo, la tendencia a la narración metahistórica, el rechazo al tono distanciado de la narrativa posmoderna, el recurso de la "mirada oblicua", la complejidad unida a la actitud popular o la experimentación lingüística,…
Il condominio di Via della Notte. Invito alla narrativa di Maria Attanasio
2015
Maria Attanasio is a skilful poet and novelist, that has been writing since the seventies. She has published six books of poems (one translated into Spanish, and two into English) and seven of prose narrative. Her novels are historical, but in the line of novelized history, and they range from the seventeenth century to the present day. Her latest novel, The Building on Night St., moves to a dystopian future that is already part of our present. The protagonists of her books are all 'nonaligned', outcasts and rebels; they are all women with one exception (The Forger of Caltagirone). All of them take place in Eastern Sicily and the land of Attanasio's birthplace, Caltagirone. The exception is…