Search results for "pic"
showing 10 items of 8215 documents
Development of polypeptide-based therapeutics for topical delivery
2019
Topical administration represents the main route to attain local therapeutic activity of bioactive agents in several organs, such as the skin or the heart by means of devices that enhance drug transport through the endothelium acting as a reservoir. The complex structure of the skin protects the human body against potentially harmful external agents; however, this protective mechanism inhibits the penetration of topically administering bioactive agents employed for the treatment of skin diseases. Unfortunately, many of the topical drugs currently used or under evaluation in clinical trials lack the appropriate physico-chemical characteristics required for delivery through the skin. However,…
Synthesis of oxazolidinones from N-aryl-carbamate and epichlorohydrin under mild conditions
2022
The reaction conditions for an enantiospecific synthesis of various N-aryl-oxazolidinones from N-aryl-carbamates and (R) or (S) epichlorohydrin were optimized. The N-aryl-oxazolidinones were applied to the synthesis of compounds of biological interest such as DuP 721, toloxatone and a linezolid analogue.
Tanatologičeskaâ problematika v povesti "Zlaâ večnostʹ" Georgiâ Peskova
2018
Pod pseudonimem Gieorgij Pieskow ukrywała się Elena Dejsza, przedstawicielka „młodszego pokolenia” pisarzy pierwszej fali emigracji rosyjskiej, autorka opowieści Zła wieczność (1932). W utworze istotne miejsce zajmuje problematyka tanatologiczna. Rozpatrywana jest ona w różnych aspektach: poruszany jest tu problem samobójstwa, odbieranego jako zwycięstwo nad śmiercią; sporo miejsca poświęca się immortologii — bibliotekarz ma obsesję na punkcie nieśmiertelności; zwraca się także uwagę na starzenie się jako zjawisko towarzyszące umieraniu; dokonuje się też zabójstwa. W sferze ideowo-tematycznej poruszany jest problem zagłady cywilizacji europejskiej. Na tanatologię artystyczną Gieorgija Piesk…
Micromaterials lipid-based for topic release of fluticasone propionate for the COPD treatment
2016
New is not always costly: evidence from online processing of topic and contrast in Japanese.
2013
Two visual ERP experiments were conducted to investigate topic and contrast assigned by various cues such as discourse context, sentential position and marker during referential processing in Japanese. Experiment 1 showed that there was no N400-difference for new vs. given noun phrases (NPs) when the new NP was expected (contrastively focused) based on its preceding context and sentential position. Experiment 2 further revealed that the N400 for new NPs can be modulated by the NP’s contrastive meaning (exhausitivity) induced from the marker. Both experiments also showed that new NPs engendered an increased Late Positivity. The reduced N400 for new vs. given supports an expectation-based lin…
Przypadek Schneidera wobec motoryki ciała jako pierwotnej postaci intencjonalności w "Fenomenologii percepcji" Maurice'a Merleau-Ponty'ego
2011
Effect of topical alendronate in periodontal defects: systematic review and meta-analysis
2021
Evaluation of Surgical Outcomes of Abdominal Radical Hysterectomy and Total Laparoscopic Radical Hysterectomy for Cervical Cancer: A Retrospective An…
2022
Although a surgical approach is one of the key treatments for stages IA1-IIA2, results of the Laparoscopic Approach to Cervical Cancer (LACC) published in 2018 radically changed the field, since minimally invasive surgery was associated with a four-fold higher rate of recurrence and a six-fold higher rate of all-cause death compared to an open approach. We aimed to evaluate surgical outcomes of abdominal radical hysterectomy (ARH) and total laparoscopic radical hysterectomy (TLRH) for cervical cancer, including data collected before the LACC trial. In our retrospective analysis, operative time was significantly longer in TLRH compared to ARH (p < 0.0001), although this disadvantage could…
Analisi comparata di tematismi e sotto categorie di analisi per i principali indicatori statistici nel turismo
2021
According to scientific literature, there is a gap in the statistical analysis of tourism due to missing data or poorly structured statistical information production services. This information, which can be classified as public goods, is currently managed by the public sector and national statistical systems. This article aims to deepen, in the literature, the main dimensions for the analysis of tourism divided into themes and subcategories. Through the use of the analysis methodology with the Leximancer software, content analysis was carried out on 202 scientific articles extracted from international literature through a selection of keywords of over 700 terms. The study returns to the the…
Llatí i consciència política a la Catalunya setcentista
2014
Resum: El propòsit d’aquest article és palesar que la presència del llatí al segle XVIII a Catalunya no es redueix a edicions escolars, documents jurídics, tractats d’apologètica catòlica i escrits de devoció i pietat. La llengua llatina serveix també per difondre idees i postulats polítics al voltant d’esdeveniments del moment. En aquestes pàgines ens centrem en una sèrie de textos en llatí que han estat menystinguts o simplement ignorats per historiadors i filòlegs per raons lingüístiques i estètiques. Objecte de la nostra anàlisi són, sobretot, els escrits que descriuen els dos setges que Barcelona va patir la tardor del 1705 i la primavera de l’any següent. Particular atenció mereixerà …