Search results for "pies"
showing 10 items of 510 documents
Australian TESOL Teachers’ Cultural Perceptions of Students
2017
ABSTRACTOver the last decade, research in the field of Teaching English to Speakers of Other Languages (TESOL) has increasingly focused on the relationship between culture and learning. Researchers such as Kumaravadivelu (2003) have been vocal in their opposition to the practice of cultural stereotyping. In the current study, Holliday’s (2005) model of Culturism was used as a theoretical basis. Six Australian TESOL teachers were interviewed to determine the nature and extent of the cultural stereotypes that they held, particularly as they pertained to specific learning-related behaviours. A qualitative analysis of the data revealed that teachers most often grouped students in terms of natio…
Optimizing systemic therapy for advanced hepatocellular carcinoma: the key role of liver function
2022
The number of effective systemic therapies for the treatment of advanced hepatocellular carcinoma (HCC) is rapidly increasing, and the advent of immunotherapy has changed the treatment paradigm for these patients, leading to significantly improved survival outcomes. However, many patients with HCC will continue to receive tyrosine kinase inhibitors, partly because of contraindications to immune checkpoint inhibitors. Currently, the best sequential first- and second-line systemic treatment remains elusive. Maintenance of optimal liver function is crucial, it is likely to impinge on temporary or permanent treatment discontinuation, and should also be considered when defining the treatment seq…
The role of cMET in non-small cell lung cancer resistant to EGFR-Inhibitors: Did we really find the target?
2014
Abstract: The advent of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) represented the most important innovation in NSCLC treatment over the last years. However, despite a great initial activity, secondary mutations in the same target, or different alterations in other molecular pathways, inevitably occur, leading to the emergence of acquired resistance, in median within the first year of treatment. In this scenario, the mesenchymal-epidermal transition (cMET) tyrosine kinase receptor and its natural ligand, the hepatocyte growth factor (HGF), seem to play an important role. Indeed either the overexpression or the amplification of cMET, as well as the overexpr…
Global distributions of diazotrophs Gamma-A nifH genes abundance - Depth integrated values computed from a collection of source datasets - Contributi…
2013
The MAREDAT atlas covers 11 types of plankton, ranging in size from bacteria to jellyfish. Together, these plankton groups determine the health and productivity of the global ocean and play a vital role in the global carbon cycle. Working within a uniform and consistent spatial and depth grid (map) of the global ocean, the researchers compiled thousands and tens of thousands of data points to identify regions of plankton abundance and scarcity as well as areas of data abundance and scarcity. At many of the grid points, the MAREDAT team accomplished the difficult conversion from abundance (numbers of organisms) to biomass (carbon mass of organisms). The MAREDAT atlas provides an unprecedente…
Topoloģijas optimizācija stieņu sistēmu modeļiem
2021
Topoloģijas optimizācijas paņēmieni ir moderns veids lai veidot efektīvus risinājumus tehniskām problēmām. Šajā darbā tiks apskatīts topoloģijas optimizācijas piegājiens lai izveidot optimālo stieņu modeli. Stieņu modeļu sistēmas ir plaši lietotas buvmehānikā, inženierijā un var būt derīgi sadzīvē. Iegūtie rezultāti palīdzēs taupīt ražošanas materiālus, enerģiju. Stieņu sistēmu galvenais pielietojums, kas būs apskatīts ir spiesto-stieptu elementu modeļi, bet rezultāti var būt viegli adaptēti arī citiem vajadzīgiem aprēķiniem. Šajā darbā ir smalki aplūkots pilns aprēķinu cikls, kas no topoloģijas optimizācijas uzdevuma, aprēķinot to ar galīgo elementu metodi ar vairākiem pārveidojumiem tiek …
Ierogamie, euritmie e ierotopie mariane in Sicilia. Il "case study" della Madonna dei Miracoli di Caltabellotta (Ag)
2021
Qual’è immagine venerata che resta come traccia mestica nella mente dei fedeli? Quella che tutto l’anno si può osservare sull’altare della chiesa o quella che solo una volta l’anno si può vedere durante la festa patronale? Partendo da queste domande in questo saggio si tracciano le origini di alcune raffigurazioni mariane siciliane, e in particolare del simulacro della Madonna del Soccorso o dei Miracoli di Caltabellotta (AG). È una ricerca ancora in nuce che propone una chiave di lettura dell’iconografia mariana inedita che partendo dall’analisi morfologica e iconografica, passando per la biologia delle immagini di warburghiana memoria, approda all’animismo e alla performance rituali. What…
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsm…
2020
AbstractAldehyde dehydrogenases (ALDHs) are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on The Cancer Genome Atlas and Gene Expression Omnibus data and detected genetic alterations in ALDH1A1, ALDH1A3, or ALDH3A1, 86% of which were gene amplification or mRNA upregulation, in 31% of nonsmall cell lung cancers (NSCLCs). The expression of these isoenzymes impacted chemoresistance and shortened survival times in patients. We hypothesized that these enzymes provide an oxidative advantage for the persistence of NSCLC. To test this hypothesis, we used genetic and pharmacological approaches with DIMATE, an irreversible inhibito…
Lipid-lowering therapy and low-density lipoprotein cholesterol goal achievement in patients with acute coronary syndromes: The ACS patient pathway pr…
2020
Background and aims: Post-acute coronary syndrome (ACS) patients are at very high risk for recurrent events and mortality, despite the availability of effective pharmacological approaches. Aim of this survey was to evaluate the compliance to ESC/EAS guidelines during the management of ACS patients and the effectiveness of secondary prevention in seven European countries.Methods: By means of an online questionnaire, data on 2775 ACS patients (either acute case or follow-up patients) were collected, including data on lipid profile, medications, follow-up visit planning, screening for familial hypercholesterolemia.Results: Lipid profiles were obtained for 91% of ACS patients in the acute phase…
Disease status, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept
2016
Background: Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigate the disease status, reasons for discontinuation and adverse events in Italian JIA patients treated with etanercept (ETN). Methods: In 2013, all centers of the Italian Pediatric Rheumatology Study Group were asked to make a census of patients given ETN after January 2000. Patients were classified in three groups: group 1 = patients still taking ETN; group 2 = patients discontinued from ETN for any reasons; group 3 = patients lost to follow-up while receiving ETN. All three…
Intravitreal therapies for non-neovascular age-related macular degeneration with intraretinal or subretinal fluid
2017
OBJECTIVE: To evaluate the efficacy of intravitreal therapies in cases of atrophic age-related macular degeneration (AMD) with subretinal or intraretinal fluid. METHODS: A retrospective review was made of the clinical charts of patients diagnosed with atrophic AMD with subretinal or intraretinal fluid. Fundus photographs and spectral-domain optical coherence tomography images were examined, and an analysis was made on the presence of fluid and its density. Neovascularisation was ruled out by fluorescein and/or indocyanine green angiography. RESULTS: The study included 14 eyes from 13 patients with a mean age of 72.64 years and a mean follow-up of 80.5 weeks. Intraretinal fluid was observed …