Search results for "pii"
showing 10 items of 437 documents
Flow cytometric kinetic assay of calcium mobilization in whole blood platelets using Fluo-3 and CD41
1999
Background: Platelet activation plays a major role in the physiology and pathology of hemostasis. Flow cytometry is a promising approach for the structural and functional analysis of platelets. However, the choice of adequate biological parameters and most technical issues are still under discussion. A rise in cytosolic free Ca 21 is a key early event that follows platelet stimulation and precedes several activation responses, including shape change, aggregation, secretion, and expression of procoagulant activity. Our objective was to set up a fast and sensitive flow cytometric method to determine the kinetics of intracellular Ca 21 mobilization in platelets, which could be performed with t…
The Prevalence of BDSM in Finland and the Association between BDSM Interest and Personality Traits
2022
According to previous research, interest in BDSM (Bondage-Discipline, Dominance-Submission and Sadomasochism) activities is high in several European countries and various BDSM practices are not uncommon. There is a limited amount of research on the personalities of BDSM practitioners, but in previous research practitioners have been found to have better overall well-being and to be more educated than the general population. The current study explored the prevalence of BDSM interest and practice in a Finnish sample (n = 8,137, age range 18–60, M = 30.14, SD = 8.08) and investigated the association between BDSM interest and personality measured with the six-factor personality measure HEXACO. …
Divergent Macroparasite Infections in Parapatric Swiss Lake-Stream Pairs of Threespine Stickleback (Gasterosteus aculeatus)
2015
Spatial heterogeneity in diversity and intensity of parasitism is a typical feature of most hostparasite interactions, but understanding of the evolutionary implications of such variation is limited. One possible outcome of infection heterogeneities is parasite-mediated divergent selection between host populations, ecotypes or species which may facilitate the process of ecological speciation. However, very few studies have described infections in populationpairs along the speciation continuum from low to moderate or high degree of genetic differentiation that would address the possibility of parasite-mediated divergent selection in the early stages of the speciation process. Here we provide…
S2-lukija tulkitsijana selkomukautetun kaunokirjallisuuden lukupiirissä
2020
This article discusses reading circles of adult Finnish as a second language (L2) readers. The books that were read and discussed in the circles were easy-to-read fiction. The study focuses on how the readers interpret what they read and what kind of support they need for their interpretations. The analysis utilizes the concept of scaffolding, used in socio-cultural learning theory. The readers’ reading stances vary from what is literally said in the text to creating their own interpretations of the hidden meanings of the text. The latter are not very common in the reading circles, although many participants express a wish to create and discuss interpretations too. The analysis shows that i…
16S rRNA sequences as diagnostic tools to elucidate potential symbiotic relationships between bacteria and the marine sponge Halichondria panicea : r…
1999
Association between physical performance and sense of autonomy in outdoor activities and life-space mobility in community-dwelling older people
2014
Objectives. To study the relationship between physical performance and sense of autonomy in outdoor activities with life-space mobility—the spatial area a person purposefully moves through in daily life—in community-dwelling older people. Design. Cross-sectional analyses of baseline data of the Life-Space Mobility in Old Age cohort study. Setting. Structured interviews in participants' homes. Participants. Community-dwelling people aged 75 to 90 (N = 848). Measurements. Sense of autonomy outdoors (Impact on Participation and Autonomy questionnaire subscale), life-space mobility (Life-Space Assessment; University of Alabama, Birmingham Study of Aging), and Short Physical Performance Battery.…
Individual and country-level factors associated with self-reported and accelerometer-based physical activity in old age: a cross-national analysis of…
2022
AbstractThis study aimed to investigate associations between individual-level (personality traits, quality of life) and country-level (gross domestic product per capita, number of policies and action plans for physical activity) factors with self-reported and accelerometer-based physical activity and cross-level interactions among European countries. Based on the Survey of Health, Ageing and Retirement in Europe (SHARE) from 2019–2020, self-reported physical activity (N = 46,617 from 27 countries) and accelerometer-based average acceleration and intensity gradient (N = 855 from 10 countries) were analyzed. Mixed-model regressions with two levels (individuals nested within countries) were us…
Hepatitis B subviral envelope particles use the COPII machinery for intracellular transport via selective exploitation of Sec24A and Sec23B
2020
Hepatitis B virus (HBV) is a leading cause of liver disease. Its success as a human pathogen is related to the immense production of subviral envelope particles (SVPs) contributing to viral persistence by interfering with immune functions. To explore cellular pathways involved in SVP formation and egress, we investigated host-pathogen interactions. Yeast-based proteomics revealed Sec24A, a component of the coat protein complex II (COPII), as an interaction partner of the HBV envelope S domain. To understand how HBV co-opts COPII as a proviral machinery, we studied roles of key Sec proteins in HBV-expressing liver cells. Silencing of Sar1, Sec23, and Sec24, which promote COPII assembly conco…
Inbreeding does not alter the response to an experimental heat wave in a freshwater snail
2019
Global climate change affects natural populations of many species by increasing the average temperature and the frequency of extreme weather events (e.g. summer heat waves). The ability of organisms to cope with these environmental changes can, however, depend on their genetic properties. For instance, genetic load owing to inbreeding could alter organisms’ responses to climate change-mediated environmental changes but such effects are often overlooked. We investigated the effects of an experimental heat wave (25°C versus 15°C) on life history (reproduction, size) and constitutive immune defence traits (phenoloxidase-like and antibacterial activity of haemolymph) in relation to inbreeding b…