Search results for "pilot"

Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot s…

2007

This study evaluated in vivo whether the flare-up effect of GnRH agonists can be suppressed through pretreatment with a GnRH antagonist. The classic flare-up effect caused by 3.8 mg goserelin acetate could not be suppressed through pretreatment using a single dosage of 3.24 mg cetrorelix acetate.

El rol de la escuela en formación democrática: diseño de un cuestionario

2021

El papel de los centros educativos en la formación democrática es fundamental para construir sociedades más equitativas e inclusivas. La literatura destaca la falta de instrumentos de evaluación de estrategias de apoyo en este ámbito con propiedades psicométricas adecuadas. El objetivo del trabajo fue construir el cuestionario 'Convivencia y participación democrática en los centros educativos' a partir de la validación por jueces y análisis de fiabilidad mediante un estudio piloto. Respecto a los jueces, participaron 16 expertos en la temática y aspectos metodológicos y en cuanto al pilotaje, se contó con 136 directores de escuela. Se analizó la validez de contenido y fiabilidad del instrum…

Multi-analyte method for the analysis of legacy and alternative brominated and chlorinated flame retardants in food products of animal origin using g…

2019

Abstract An analytical method was developed and validated for the analysis of 32 halogenated flame retardants (HFRs), including 13 polybrominated diphenyl ethers (PBDEs), 9 dechlorane-related compounds (DRCs) and 10 of the so-called alternative BFRs in food samples of animal origin. Gas chromatography (GC) coupled with magnetic sector high resolution mass spectrometry (HRMS) was used for the instrumental analysis. Intralaboratory validation of the developed method was performed in terms of recovery, repeatability, linear calibration ranges, instrumental and method limits of quantitation (i-LOQ and m-LOQ). Where possible, trueness was verified by the analysis of reference materials (RMs). Fo…

Use of running plates by floor housed rats: A pilot study

2021

The outfit of husbandry facilities of, and the enrichment provided for, experimental rodents plays an important role in the animals’ welfare, and hence also for the societal acceptance of animal experiments. Whether rats and mice benefit from being provided with running wheels or plates is discussed controversially. Here we present observations from a feeding experiment, where rats were provided a running plate. As a pilot study, six identical cages, with three animals per cage, were filmed for six days, and the resulting footage was screened for the number of bouts and the time the animals spent on the plates. The main activities observed on the plate in descending order were sitting (18.…

Redescription ofOdhneriella subtila (Skrjabin, 1959) (Digenea: Campulidae) from the intestine ofGlobicephala melaena (Traill, 1809) (Cetacea: Delphin…

1989

During parasitological investigations of long-finned pilot whales,Globicephala melaena (Traill, 1809), in the Faroe Islands, the trematode speciesOdhneriella subtila (Digenea: Campulidae), parasitising the small intestine, was detected. Skrjabin's (1959) original description of this species was based on a single individual. The collection and availability for study of several thousands of specimens permitted the redescription of this campulid and the noting of some new morphological characters. This trematode is reported for the first time from the long-finned pilot whale, and the Atlantic Ocean is a new locality record.

Low dosage liposomal amphotericin B in the treatment of Candida infections in critically ill patients.

2011

Farmed Gilthead Sea Bream (Sparus aurata) by-Products Valorization: Viscera Oil ω-3 Enrichment by Short-Path Distillation and In Vitro Bioactivity Ev…

2021

This study shows a pilot scale protocol aimed to obtain an omega 3-enriched oil after the processing of farmed gilthead sea bream viscera (SBV)

Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinic…

2013

OBJECTIVES: The involvement of different factors in the onset of thoracic aortic aneurysm (TAA) in patients with a bicuspid aortic valve (BAV) vs those with a tricuspid aortic valve (TAV) is well recognized. However, the molecular, genetic and cellular mechanisms driving TAA remain unclear. The aim of this study was to identify the different mechanisms involved in TAA development in patients with BAV vs TAV. METHODS: Aorta specimens and DNA samples were collected from 24 BAV (18 men and 6 women; mean age: 54.2 ± 14.39 years) and 110 TAV (79 men and 31 women, mean age: 66 ± 9.8 years) patients. A control group of 128 subjects (61 men and 67 woman, mean age: 61.1 ± 5.8 years) was also enrolle…

Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting

2020

Abstract Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Methods Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-h ambulatory ECG was performed. Results Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ± 8.8, disease duration: 5.0 ± 4.7). Mean SCOPA-AUT scor…

Association between COX-2 rs 6681231 genotype and interleukin-6 in periodontal connective tissue. A pilot study.

2014

[Objectives] The aim of this pilot study was to investigate associations between IL-6 and COX-2 expression in gingival biopsies and both clinical diagnosis and genotypes in the IL-6 and COX-2 genes. [Design] A case-control study included 41 gingival biopsies obtained from Caucasian patients grouped according to clinical diagnosis of gingival health (n = 10), gingivitis (n = 15) or chronic periodontitis (n = 16). Immunohistochemistry analyses were performed to determine COX-2 expression in lamina propria, IL-6 expression in lamina propria and gingival epithelium and level of inflammatory cell infiltrate. Individual DNA was extracted and genotyped by real-time PCR for IL6 SNPs rs 2069827 and …