Search results for "pine"

Frustrats, incompresos i oblidats: els expedicionaris espanyols de la il·lustració

2013

En l’ultim terc del segle XVIII la corona espanyola es va incorporar a la practica de promoure expedicions que, junt amb la reivindicacio sobre els territoris visitats, elaboraren tambe estudis i catalegs de les riqueses naturals trobades. La majoria dels expedicionaris van topar a la tornada amb la incomprensio i l’oblit de les mateixes institucions que havien promogut el seu viatge.

Happiness in Physical Activity: A Longitudinal Examination of Children Motivation and Negative Affect in Physical Activity

2020

Physical activity has beneficial effects on health and is extremely recommended for children's well-being. Understanding risk factors that could cause negative affect in children practicing physical activity is hugely relevant, and there is a growing consensus that autonomous and controlled motivation in the self-determination theory (SDT) framework could offer a broader perspective. Consequently, this study aims to examine the longitudinal relations between autonomous motivation, controlled motivation, and negative affect in physical activity, using a sample of children that regularly participate in physical activity. One hundred forty children in the range age between 7 and 11 (M = 8.45, …

A Note on the High Stability of Happiness: The Minimal Effects of a Nuclear Catastrophe on Life Satisfaction

2008

Using life satisfaction as a direct measure of individual utility has become popular in the empirical economic literature. In this context, it is crucial to know what circumstances or changes the measure is sensitive to. Is life satisfaction a volatile concept that is affected by minor changes in life circumstances? Or is it a reliable measure of personal happiness? This paper will analyze the impact of a catastrophe, namely the nuclear catastrophe of Chernobyl, on life satisfaction. I use longitudinal data from the German Socio-Economic Panel Study and especially information collected on a monthly basis which allows the researcher to study calendar effects. The following clear-cut results …

Religiosity and meditation practice : Exploring their explanatory power on psychological adjustment

2019

There has been increased interest in the relationships between religiosity, meditation practice and well-being, but there is lack of understanding as to how specific religious components and distinct meditation practices could influence different positive and negative psychological adjustment outcomes. The aim of this study was to assess the explanatory power of religious beliefs and the practice of prayer, focused attention (FA), open monitoring (OM), and compassion meditation (CM) on psychological adjustment, taking into consideration a number of practice-related variables such as session length, frequency of practice and lifetime practice. Psychological adjustment was assessed by means o…

Age 7–8 Years

1993

Determination of Drug Concentrations in Serum and Dopamine Receptor Occupancy in Brain for Optimal Antipsychotic Drug Therapy

2009

Evidence has been given that antipsychotic effects of dopamine receptor antagonists are associated with 60 and 80% striatal dopamine D2 and D3 receptor occupancy. Receptor occupancy correlates well with concentrations of the antipsychotic drugs in serum or plasma, much better than the dose. The latter is consistent with weak correlations between antipsychotic dose and serum concentrations and explained by the high interindividual variabilities in drug metabolism. Using positron emission tomography (PET) for in vivo determination of dopamine receptor occupancy in conjunction with drug concentration measurements “therapeutic windows” could be calculated for the atypical antipsychotic drugs am…

Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity.

2019

The synthesis of inhibitors of SphK2 with novel structural scaffolds is reported. These compounds were designed from a molecular modeling study, in which the molecular interactions stabilizing the different complexes were taken into account. Particularly interesting is that 7‐bromo‐2‐(2‐phenylethyl)‐2,3,4,5‐tetrahydro‐1,4‐epoxynaphtho[1,2‐b]azepine, which is a selective inhibitor of SphK2, does not exert any cytotoxic effects and has a potent anti‐inflammatory effect. It was found to inhibit mononuclear cell adhesion to the dysfunctional endothelium with minimal impact on neutrophil–endothelial cell interactions. The information obtained from our theoretical and experimental study can be us…

Benzodiazepines: specific competitors for the binding of L-tryptophan to human serum albumin.

1975

By means of the gel filtration technique, the effect of nine benzo-diazepine derivates on the binding of l-tryptophan to human serum albumin was investigated. Using equimolar tryptophan and benzodiazepine concentrations, all benzodiazepines with binding constants higher than 104 (M−1), displace l-tryptophan from its binding site to a high degree. The mechanism of the displacement was characterized as a competition for a common binding site. Some of the benzodiazepines displace l-tryptophan to a greater extent than salicylic acid. The benzodiazepines and tryptophan are the only substances known with a high degree of stereospecific binding to human serum albumin. This study shows that there i…

Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABAA Receptors

2011

Ethyl alcohol (ethanol) has many molecular targets in the nervous system, its potency at these sites being low compared with those of sedative drugs. This has made it difficult to discover ethanol’s binding site(s). There are two putative binding sites at gamma-aminobutyric acid (GABA) type A receptor subtypes for the proposed ethanol antagonist Ro 15-4513, the established gamma2 subunit-dependent benzodiazepine site and the recently reported delta subunit-dependent Ro 15-4513/ethanol binding site. Here, we aimed at clarifying the in vivo role of Ro 15-4513 at these two sites. We found that the antagonism of ethanol actions by Ro 15-4513 in wildtype mice was dependent on the test: an open f…

Comparison of the contractile effects of endothelin-1 and sarafotoxin S6b in goat isolated cerebral arteries

1992

1. The effects of endothelium-derived endothelin-1 and snake venom-derived sarafotoxin S6b, peptides with striking structural and functional similarities, were examined and compared in isolated middle cerebral arteries of goats. 2. Endothelin-1 and sarafotoxin S6b contracted cerebral arteries in a concentration-dependent manner. The potency of endothelin-1 (EC50 = 4.9 (3.9-6.2) x 10(-10) M) was about ten times higher than that of sarafotoxin S6b (EC50 = 5.5 (4.4-6.9) x 10(-9) M). The tension returned to basal values after repeated washings and contraction with endothelin-1 could be reproduced. Endothelin-1 and sarafotoxin S6b induced further contraction in arteries precontracted with prosta…