Search results for "pine"

showing 10 items of 2022 documents

Innovations in the Art of Microneurosurgery for Reaching Deep-Seated Cerebral Lesions.

2019

Deep-seated cerebral lesions have fascinated and frustrated countless surgical innovators since the dawn of the microneurosurgical era. To determine the optimal approach, the microneurosurgeon must take into account the characteristics and location of the pathological lesion as well as the operator's range of technical expertise. Increasingly, microneurosurgeons must select between multiple operative corridors that can provide access to the surgical target. Innovative trajectories have emerged for many indications that provide more flexible operative angles and superior exposure but result in longer working distances and more technically demanding maneuvers. In this article, we highlight 4 …

Intracranial Arteriovenous MalformationsMicrosurgerybusiness.industryNormal tissueSkull Base NeoplasmsNeurosurgical ProceduresInnovation Microneurosurgery The Neurosurgical Atlas Operative technique Surgical corridors03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisMedical IllustrationMeningeal NeoplasmsMedicineHumansSurgeryOperations managementNeurology (clinical)businessMeningiomaPinealoma030217 neurology & neurosurgeryStrengths and weaknessesCraniotomyWorld neurosurgery
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Diagnosis and therapeutic management of primary headache in an emergency setting

2013

Introduction and aim: Much headachers are under or mis-diagnoses and data regarding the proportion of patients attending an emergency department (ED) because of headache are still few. We conducted a retrospective observational study in an ED with the following aims: (a) estimate the proportion of headache attending to an ED (b) to estimate and describe the therapeutic management of primary headache and (c) to assessment the exam most frequently requested. Materials and methods: We collected data regarding patients diagnosed with headache consecutively attending the ED of the University of Palermo between September 2011 and March 2012. The study was approved by the ethics committee. Results: Between the semester evaluated 25110 subjects were admitted to ED headache suffers were equal to 1.6 %. Of these 263 (63.1 %) were woman and 154 (36.9 %). Mean age was 44.2 (DS ± 18.4) years (p = 0.068).According to ED registry headache admission was as follow assigned: 76.5 % with a diagnosis of headache 22.8 % with a secondary headache 0.7 % with Trigeminal Autonomic Cephalgias (TACs). Among those with a primary headache about 36 % of patient did not received a pharmacological treatment. Monotherapy was prescribed less frequently than combination therapy (19.1 vs 44.5 %).In monotherapy the most frequent medication were NSAIDs (28.3 %) benzodiazepines (26.7 %) and dopamine antagonists (11.7 %). Among those with a primary headache a CT scan was performed in the 124 subjects and 111 (34.8 %) had a neurologist consultation. Discussion: Our data are in line with the one previously reported in literature. The most frequently medication in the Italian ED were NSAIDs benzodiazepines dopamine antagonists and steroids. Neverless our data unlikely can be compared to other study give a snapshot. We believe that much more can be done to improve treatment of primary headache in ED.Settore MED/26 - Neurologia
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Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

2015

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI 50 mean values at low micromolar level (3.72–5.13 μM).

Isoindolo[15]benzoxazepineChemistryStereochemistryDrug Discovery3003 Pharmaceutical ScienceOrganic Chemistry5]benzoxazepine4]benzoxazinoneAntiproliferative activityRing (chemistry)Settore CHIM/08 - Chimica FarmaceuticaBiochemistryHuman tumorchemistry.chemical_compoundIsoindolo[14]benzoxazinoneDrug DiscoveryIsoindolo[1Antiproliferative activity; Isoindole; Isoindolo[1; 4]benzoxazinone; Isoindolo[1; 5]benzoxazepine; Biochemistry; Organic Chemistry; Drug Discovery3003 Pharmaceutical ScienceIsoindoleIsoindole
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Isoindolo[1,5]benzoxazepines as potential antitumor and/or antiviral agents

2013

Isoindolo[15]benzoxazepines antitumor antiviral agentsSettore CHIM/08 - Chimica Farmaceutica
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Chemical composition of the essential oil from the aerial parts of Ononis reclinata L. (Fabaceae) grown wild in Sicily

2016

In the present study, the chemical composition of the essential oil from aerial parts of Ononis reclinata L., a species not previously investigated, collected in Sicily was evaluated by GC and Gas chromatography-Mass spectrometry. The main components of O. reclinata were menthone (43.6%), isopimpinellin (38.4%) and pulegone (11.2%). The comparison with other studied oils of genus Ononis showed a peculiar and characteristic profile.

IsopimpinellinChromatography GasmenthoneFlowersPlant ScienceBiology01 natural sciencesBiochemistryPlant StemGas Chromatography-Mass SpectrometryAnalytical Chemistrylaw.inventionchemistry.chemical_compoundGenuslawOnonisBotanyOils VolatileOnoniSicilyChemical compositionEssential oilpulegoneOnonis reclinataPlant Stems010405 organic chemistryOrganic ChemistryFabaceaeFabaceaeisopimpinellinPlant Components Aerialbiology.organism_classificationMenthone0104 chemical sciencesPlant Leavesvolatile component010404 medicinal & biomolecular chemistrychemistryChromatography GaFlowerOnonisPlant LeavePulegoneNatural Product Research
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Evaluation of furanocoumarins from seeds of the wild parsnip (Pastinaca sativa L. s.l.).

2018

Abstract Although the wild parsnip (Pastinaca sativa L. s.l.) fruits are known to contain linear and angular furanocoumarins, the individual components of the seeds have not been fully identified and quantitated, and, in the case of immature seeds, reported. In view of this, the main furanocoumarin compounds were extracted using pyridine, and were isolated using semi-preparative high-performance liquid chromatography. The structural elucidation of isolated compounds was done based on detailed spectral analysis conducted by liquid chromatography–electrospray ionization–mass spectrometry (LC–ESI/MS), 1H and 13C NMR and, where possible, by gas chromatography–mass spectrometry (GC–MS). The quan…

IsopimpinellinSpectrometry Mass Electrospray IonizationClinical BiochemistryWild parsnip030226 pharmacology & pharmacy01 natural sciencesBiochemistryBergaptenGas Chromatography-Mass SpectrometryAnalytical Chemistry03 medical and health scienceschemistry.chemical_compoundFuranocoumarin0302 clinical medicinefoodLimit of DetectionFurocoumarinsmedicinePastinacaPastinacaChromatography High Pressure LiquidChromatographyApiaceaebiologyImperatorinMethoxsalen010401 analytical chemistryReproducibility of ResultsCell BiologyGeneral Medicinebiology.organism_classificationfood.food0104 chemical scienceschemistrySeedsLinear Modelsmedicine.drugJournal of chromatography. B, Analytical technologies in the biomedical and life sciences
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Binding Sites for Ca2+‐Channel Effectors and Ryanodine inPeriplaneta americana—Possible Targets for New Insecticides

1996

The calcium channel and the 'calcium release channel' of muscle membrane of the cockroach Periplaneta americana have been characterized. Biological assays with calcium channel blockers and ryanodine on different insects and acari revealed pronounced insecticidal effects with ryanodine, but not with calcium channel blockers, at concentrations between 0.1 and 300 μg ml -1 . Skeletal muscle membranes derived either from the tubular network or from the sarcoplasmatic reticulum of P. americana were characterized with respect to the binding of the dihydropyridine (DHP) [ 3 H]isradipine (PN 200-110), the phenylalkylamine [ 3 H]verapamil and the alkaloid [ 3 H]ryanodine. Preliminary binding studies…

IsradipineChemistryRyanodine receptorPhenylalkylamine bindingCalcium channelDihydropyridinemedicineVerapamilCalcium Channel BindingPharmacologyLigand (biochemistry)Applied Microbiology and Biotechnologymedicine.drugPesticide Science
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Arto Sipinen Jyväskylän yliopiston uudisrakennusten arkkitehtina 1969-2000

2002

JyväskyläSipinen Artomiesiläisyys
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Elisabet Järnefeltin kirjallinen salonki Kauppis-Heikin kirjailijauran käännekohtana

2017

Järnefelt ElisabetKauppinen HeikkiKauppis-Heikkikirjoittaminen
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Ordering kinetics in synthetic Mg(Al,Fe3+)2O4 spinels: Quantitative elucidation of the whole Al-Mg-Fe partitioning, rate constants, activation energi…

2014

A novel procedure, based on the application of the kinetics simulator Gepasi, has been successfully applied for modeling the cation ordering process in two synthetic Mg(Al2-yFe3+y)O4 spinels (y~ 0.39 and 0.54, samples F39 and F54, respectively). The kinetic profiles suggested a two-stage mechanism, with rapid inter-site exchange of Fe3+ with Mg followed by slow exchange of Al with Mg. The trial to apply the classical approaches, based on the explicit solutions of the differential equations corresponding to single-cation (Sha-Chappel model) or two-cation (Müller model) exchange reactions, proved not feasible in the whole time range, thus implying a lack of information about the exchange proc…

KineticSettore GEO/06 - MineralogiaspinelChemistryKineticsCationic polymerizationMineralogyActivation energyRate equationKinetic energyintersite cation exchangeKineticsGeophysicsReaction rate constantIntersite cation exchange spinels kinetics rate constant activation energy geothermometersactivation energyGeochemistry and PetrologyIron contentintersite cation exchange; spinels; Kinetics; activation energy; geothermometerPhysical chemistryspinelsgeothermometerTime rangeSettore CHIM/02 - Chimica Fisica
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