Search results for "pits"

Le fattispecie contrattuali atipiche: logiche argomentative e modelli processuali

2013

Endocytosis in skeletal muscle fibers.

1999

Defining the organization of endocytic pathway in multinucleated skeletal myofibers is crucial to understand the routing of membrane proteins, such as receptors and glucose transporters, through this system. Here we analyzed the organization of the endocytic trafficking pathways in isolated rat myofibers. We found that sarcolemmal-coated pits and transferrin receptors were concentrated in the I band areas. Fluid phase markers were taken up into vesicles in the same areas along the whole length of the fibers and were then delivered into structures around and between the nuclei. These markers also accumulated beneath the neuromuscular and myotendinous junctions. The recycling compartment, lab…

Congenital lower lip pits : Van der Woude syndrome

2018

The Van der Woude syndrome is a rare autosomal dominant development malformation characterized by a paramedian lip pits and /or sinuses or conical elevation of lower lip associated with cleft lip and or palate. These congenital lip pits usually appear clinically in the vermilion border of lip, with or without secretion. The critical region of VWS has been identified to be at Iq32 to 41 with high, but incomplete penetrance and variable expressivity. Therapeutic intervention is generally required for cosmetic reason or when recurrent inflammation is present. Dental surgeon should be aware of this syndrome, as it is associated with variety of other congenital malformation. van der woude syndro…

Settlement, radiocarbon dates and craft productions during Late Neolithic and Bell Beaker periods in the ‘corredor de Montesa’ (Valencia, Spain). The…

2014

[EN] In this paper we present the results related to the excavation works conducted in Late Neolithic and Bell Beaker sites of Quintaret (Montesa, Valencia) and Corcot (l’Alcúdia de Crespins, Valencia), both in the middle valley of Canyoles river. The sites, neighboring each other, offer a quite different volume of information (Quintaret: 51 structures; Corcot: 4 structures). 14C dates allow us to define the occupation of this area of the valley along the first half of the III millennium cal BC. The presence of bell beaker ceramic in archaeological record of Quintaret is limited to just one structure (Q138), where at least 7 different vessels have been identified. Other prominent point of t…

A 5500-year oxygen isotope record of high arctic environmental change from southern Spitsbergen

2017

The oxygen isotope composition of chironomid head capsules in a sediment core spanning the past 5500 years from Lake Svartvatnet in southern Spitsbergen was used to reconstruct the oxygen isotope composition of lake water (δ18Olw) and local precipitation. The δ18Olw values display shifts from the baseline variability consistent with the timing of recognized historical climatic episodes, such as the Roman Warm Period, the Dark Ages Cold Period and the ‘Little Ice Age’. The highest values of the record, ca. 3‰ above modern δ18Olw values, occur at ca. 1900–1800 cal. yr BP. Three negative excursions increasing in intensity toward the present, at 3400–3200, 1250–1100, and 350–50 cal. yr BP, are…

Bradykinin-induced Internalization of the Human B2Receptor Requires Phosphorylation of Three Serine and Two Threonine Residues at Its Carboxyl Tail

1999

The binding of bradykinin (BK) to B2 receptor triggers the internalization of the agonist-receptor complex. To investigate the mechanisms and the receptor structures involved in this fundamental process of receptor regulation, the human B2 receptor was mutated within its cytoplasmic tail by complementary strategies of truncation, deletion, and amino acid substitution. Ligand binding, signal transduction, internalization as well as phosphorylation were studied for the mutated receptors expressed in COS, CHO, and HEK 293 cells. Truncation of 44 out of 55 amino acid residues of the receptor's cytoplasmic tail corresponding to positions 321-364 did not alter the kinetics of BK binding and the r…

Fouille d’un quartier funéraire des Ier et IIe s. dans le suburbium de Soissons/Augusta Suessionum : aires de crémation et inhumations d’enfants

2012

In the beginning of 2008 a preventive excavation has been conducted on about 1200 m2 of a large antique cemetery situated upon the butte Saint-Jean at Soissons (Aisne). In this cemetery, almost unknown, located south-west of the Roman town Augusta Suessionum a consistent activity in the part being excavated took place between the Augustan era and mid 2nd c. The total number of inhumations uncovered is 186 (mainly of infants). Cremations were executed from the very beginning altogether with inhumations, in more or less close proximity to them according to periods, then became predominant to the detriment of burials which were just previously arranged. Different structures clearly connected t…

Les systèmes de fosses profondes à la Pré- et Protohistoire : cartographie des fosses mésolithiques et des Schlitzgruben à l’échelle nationale

2016

A nation-wide project of mapping deep pits dating to Pre- and Protohistory in continental France was launched by INRAP in 2015. Positioned at the interface between regional projects, on pits with V-, Y- and W-shaped profile (Schlitzgruben) as well as on deep pits dated to the Mesolithic, and nation-wide studies carried out by the INRAP (such as those focusing on the Bronze Age and Early Iron Age), the current project aims to bring together data and actors within the field of rescue archaeology in order to create an operational mapping tool. Constructed on a rational basis combining four levels of information (operation, pit systems, pits, absolute dates), this tool should ensure the incorpo…

Mesolithic pit-sites in Champagne (France): First data, key issues

2015

International audience; In less than a decade, more than 30 sites and around 200 deep pits dated to the Mesolithic have been identied in the Champagne-Ardenne region (north-eastern France). This paper describes the main characteristics of these features and provides some clues for their interpretation. This unexpected but apparently common type of site clearly implies a more marked territoriality and a greater social complexity than generally proposed for the period in continental northern France.

Miega traucējumi un to saistība ar urināciju nakts laikā

2020

Maģistra darba tēma ir ‘’Miega traucējumi un to saistība ar urināciju nakts laikā’’. Tēmas aktualitāti nosaka fakts, ka urinācija nakts laikā ir nopietna terapeitiska problēma, jo tā lielā mērā ietekmē miega kvalitāti, kas savukārt nelabvēlīgi atspoguļojas problēmas skarto cilvēku fiziskajā un garīgajā veselībā. Pareiza cēloņu identificēšana nakts urinācijai ļauj uzsākt agrīnu ārstēšanu. Maģistra darba mērķis ir izpētīt miega traucējumu iemeslus un to saistību ar urināciju nakts laikā, kā arī grupu raksturojumu un nakts urinācijas izplatību pacientiem, kas apmeklēja urodinamikas izmeklējumu. Pētniecības uzdevumi ir izvērtēt un analizēt sūdzības urodinamikas pacientiem ar nakts urināciju, no…