Search results for "pituitary adenoma"
showing 5 items of 15 documents
Janus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hor…
2012
OBJECTIVE: An increased prevalence of hematological abnormalities is reported in acromegaly, but to date no reports about the presence of the Janus Kinase (JAK) 2 mutation in acromegalic patients have been described. DESIGN: We report the complex clinical presentation of the unique case, never described, of acromegaly due to GH-secreting pituitary adenoma associated with JAK2 V617F mutation. RESULTS: The patient shows primary thrombocythemia and myelofibrosis, due to JAK2 V617F mutation, severe visceromegaly and a peculiar clinical course of the disease characterized by discrepant values of GH and IGF-1 during somatostatin analog (SA) treatment despite a significant reduction in pituitary a…
Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs
2020
Pituitary carcinomas (PCa) are extremely rare, indistinguishable from pituitary adenomas on histopathological grounds and have a poor prognosis. Most PCa start as PRL or ACTH secreting tumors in males, with relapsing invasive behaviour, refractoriness to medical and radiotherapy and increasing hormonal levels. The presence of distant metastases is still required for the diagnosis of PCa. The association with genetic endocrine diseases must be taken into account, since it adds further risk of evolution towards malignancy. Intradural spinal metastases have also been reported, so a complete craniospinal MR evaluation is recommended, when clinically indicated. We report a case of PCa, associate…
Impact of CT and MR on the Diagnostic Evaluation of Neurologic and Neurosurgical Diseases
1989
Today CT and MR are considered to be the most important and most reliable methods for the diagnosis of brain tumors. The sensitivity of these modalities in the detection of intracranial tumors approaches 100%. The extraordinary value of both methods is based not only on this high detection rate but also on their ability to localize tumors in relation to vital centers, assess their mass effect, and establish the tissue type of the lesion (= specificity).
Computed Tomography in Brain Tumors
1981
Craniocerebral injury and brain tumor are the two most important indications for CT studies. There is unanimous agreement that computed tomography is unequalled in its diagnostic accuracy in demonstration of intracranial tumors. Our own experience is based on observations in 3,750 patients with brain tumors or cerebral metastases who were studied in the period from December 1974 to March 1980 (Table 1). Initial CT studies demonstrated the intracranial tumor or tumors in 3,589 cases (95.7%). Several CT examinations were necessary for diagnosis of a brain tumor in 112 patients (3.0%). Other diagnostic procedures or postmortem studies revealed a brain tumor which had not been demonstrated with…