Search results for "placement"

Anderson-Fabry Disease: A Multiorgan Disease

2013

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A . FD causes glycolipids, such as globotriaosylceramide (Gb3), to accumulate in the vascular endothelium of several organs (fig.2), including the skin, kidneys, nervous system, and heart, thereby triggering inflammation and fibrosis . These processes generally result in organ dysfunction, which is usually the first clinical evidence of FD. Patients with classic FD have various symptoms, eg, acroparesthesias, hypohidrosis, angiokeratomas, corneal opacities, cerebrovascular lesions, cardiac disorders, andrenal dysfunction.However, evolving knowledge about the natural course o…

CNS manifestations of Fabry's disease

2006

Summary Background Fabry's disease is a rare hereditary lysosomal storage disease with multiorgan involvement. Deficiency of α-galactosidase A activity leads to accumulation of neutral glycosphingolipids, especially in vascular endothelial and smooth-muscle cells. Along with progressive renal and cardiac dysfunction, stroke is a major and often life-threatening burden of the disease. Cerebral vasculopathy, confirmed by neuropathological, neuroradiological, and functional studies, occurs commonly and leads to ischaemic cerebrovascular events at an early age. Recent developments Fabry's disease is an X-linked disease and women have been regarded as only mildly affected carriers. However, rese…

Improved technique for stereotactic placement of nerve grafts between two locations inside the rat brain

2008

Peripheral nerve grafts have shown the ability to facilitate central axonal growth and regenerate the adult central nervous system. However, the detailed description of a technique for atraumatic graft placement within the brain is lacking. We present a stereotactic procedure to implant a peripheral nerve graft within a rat's brain with minimal brain tissue damage. The procedure permits a correct graft placement joining two chosen points, and the survival and integration of the graft in the host tissue with a light glial reaction, with evidence of central axonal growth inside the graft, at least up to 8 weeks after its implantation. (C) 2008 Elsevier B.V. All rights reserved.

Static instability analysis for travelling membranes and plates interacting with axially moving ideal fluid

2010

The out-of-plane instability of a moving plate, travelling between two rollers with constant velocity, is studied, taking into account the mutual interaction between the buckled plate and the surrounding, axially flowing ideal fluid. Transverse displacement of the buckled plate (assumed cylindrical) is described by an integro-differential equation that includes the centrifugal force, the aerodynamic reaction of the external medium, the vertical projection of membrane tension, and the bending force. The aerodynamic reaction is found analytically as a functional of the displacement. To find the critical divergence velocity of the moving plate and its corresponding buckling mode, an eigenvalue…

Transcranial Magnetic Stimulation Combined With Nicotine Replacement Therapy for Smoking Cessation: A Randomized Controlled Trial.

2015

Abstract Background Further evidence suggests that repetitive Transcranial Magnetic Stimulation (rTMS) is an effective method to reduce tobacco craving among smokers. Hypothesis As relapse is common within a few days after smoking cessation, we hypothesized that combining the anti-craving effects of rTMS with Nicotine replacement therapy (NRT) to attenuate withdrawal symptoms could increase abstinence rates in smokers with severe nicotine dependence who quit smoking. Methods Thirty-seven smokers who failed to quit with the usual treatments were randomly assigned to two treatment groups to receive either active ( n  = 18) or sham ( n  = 19) 1-Hz rTMS of the right dorsolateral prefrontal cort…

Perturbations of symmetric elliptic Hamiltonians of degree four

2006

AbstractIn this paper four-parameter unfoldings Xλ of symmetric elliptic Hamiltonians of degree four are studied. We prove that in a compact region of the period annulus of X0 the displacement function of Xλ is sign equivalent to its principal part, which is given by a family induced by a Chebychev system; and we describe the bifurcation diagram of Xλ in a full neighborhood of the origin in the parameter space, where at most two limit cycles can exist for the corresponding systems.

Diffusion of colloids in one-dimensional light channels

2004

Single-file diffusion (SFD), prevalent in many chemical and biological processes, refers to the one-dimensional motion of interacting particles in pores which are so narrow that the mutual passage of particles is excluded. Since the sequence of particles in such a situation remains unaffected over time t, this leads to strong deviations from normal diffusion, e.g. an increase of the particle mean-square-displacement as the square root of t. We present experimental results of the diffusive behaviour of colloidal particles in one-dimensional channels with varying particle density. The channels are realized by means of a scanning optical tweezers. Based on a new analytical approach (Kollmann 2…

In silico, spectroscopic, and biological insights on annelated pyrrolo[3,2-e]pyrimidines with antiproliferative activity

2013

The in silico COMPARE analysis was performed on 8-[3-(piperidino)propyl]-4,10-dimethyl-9-phenyl-6-(methylsulfanyl)-3,4-dihydropyrimido[1,2-c]pyrrolo[3,2-e]pyrimidin-2(8H)-one, a compound with promising antiproliferative activity, previously synthetized and screened against a panel of 60 human tumor cell lines. The results evidenced that this compound matches the biological properties of Chromomycin A3 and Actinomycin D, known drugs with high DNA binding affinity. Prompted by such results, a thorough spectroscopic investigation of its DNA aqueous solutions was performed, with the aim to verify its DNA-binding properties. DNA groove-binding interaction was assigned by UV-vis spectrophotometri…

Non-porous microparticulate supports in high-performance liquid chromatography (HPLC) of biopolymers — concepts, realization and prospects

1986

A symmetric tangent stiffness approach to cohesive mechanical interfaces in large displacements

2022

The present article proposes a formulation for a cohesive interface element in large displacement conditions. Theoretical and computational aspects, useful for an effective and efficient finite element implementation, are examined in details. A six-node (or higher) isoparametric interface element for two dimensional cohesive fracture propagation problems is developed. The element operators are consistently derived by a variational approach enforced in the current configuration, where a current frame is defined with axes tangential and normal to the middle line of the interface opening displacement gap. Under the constitutive assumption of small value of the modulus of the vector product bet…