Search results for "plastic"
showing 10 items of 7296 documents
3-(6-Phenylimidazo [2,1-
2019
A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel of pancreatic ductal adenocarcinoma (PDAC) cells, including SUIT-2, Capan-1 and Panc-1. Compounds 9c and 9l, showed relevant in vitro antiproliferative activity on all three pre-clinical models with half maximal inhibitory concentration (IC50) ranging from 5.11 to 10.8 µM, while the compounds 9e and 9n were active in at least one cell line. In addition, compound 9c significantly inhibited the migration rate of SUIT-2 and Capan-1 cells in the scratch wound-healing assay. In conclusion, our results will support further studies to increa…
Plasticity in the trophic niche of an invasive ant explains establishment success and long‐term coexistence
2021
Invasive species are one of the main threats to biodiversity worldwide and the processes enabling their establishment and persistence remain poorly understood. In generalist consumers, plasticity in diet and trophic niche may play a crucial role in invasion success. There is growing evidence that invasive ants, in particular, occupy lower trophic levels in their introduced range compared to the native one, but evidences remain fragmented. We conducted stable isotope analysis at five locations distributed on two continents to infer the trophic position of the invasive ant Formica paralugubris in the native and introduced part of the range. This species forms large colonies and can be a vorac…
Aroma compound transfer between a solid food matrix and packaging films: a comprehensive approach
2008
International audience; Food quality is highly dependent on mass transfers occurring in food / packaging systems during storage. Particularly, aroma compound transfers are influenced by the composition and structure of the packaging and food matrix, the physico-chemical properties of aroma compounds and the conditions of the external environment (1). The influence of the food matrix on aroma compound-packaging film interactions was little studied in the literature (2,3). The objective of this work, in the framework of the French project CANAL ARLE, is to better understand aroma compound transfer into and through cellulosic and thermoplastic packaging films by taking into account their inter…
Looking for the best immune-checkpoint inhibitor in pre-treated NSCLC patients: An indirect comparison between nivolumab, pembrolizumab and atezolizu…
2017
Immune-checkpoint inhibitors represent the new standard of care in patients with advanced NSCLC who progressed after first-line treatment. This work aim to assess any difference in both efficacy and safety profiles among Nivolumab, Pembrolizumab and Atezolizumab in pre-treated NSCLC patients. Randomized clinical trials comparing immune-checkpoint inhibitor versus docetaxel in pre-treated patients with advanced NSCLC were included and direct comparison meta-analysis of selected trials have been performed. Subsequently the summary estimates of Nivolumab, Pembrolizumab and Atezolizumab emerging from the direct meta-analysis were selected to provide the pooled estimates of hazard ratio (HR) and…
Quantities, environmental footprints and beliefs associated with household food waste in Bosnia and Herzegovina.
2019
The objectives of this research were to identify the quantities and global warming, acidification and eutrophication potentials associated with household food waste in Bosnia and Herzegovina. In parallel, this study investigated perceptions related to food waste and using the quality function deployment for environment model, correlated reasons for discarding food waste and beliefs associated with food waste. Based on this study, it is estimated that around 2.8 kg of food waste is disposed of by the average household every week. Global warming, acidification and eutrophication potentials associated with household food waste are, on average, 3.49 kg CO2e/week, 2.42 g SO2e/week and 8.70 g PO…
Relapse risk after autologous transplantation in patients with newly diagnosed myeloma is not related with infused tumor cell load and the outcome is…
2006
BACKGROUND AND OBJECTIVES: This European Group for Blood and Marrow Transplantation (EBMT) multicentre randomized phase III study was designed to assess the safety and efficacy of CD34+ selection in newly diagnosed myeloma patients undergoing autologous transplantation. DESIGN AND METHODS: One hundred and eleven patients responsive to initial chemotherapy were randomized to receive CD34+ selected (arm A) or unselected PBPC (arm B) after conditioning with high-dose melphalan and TBI. ASO-PCR was used to assess purging efficacy and reinfused tumor load. Tumor load could be assessed in 59 patients. RESULTS: CD34+ selection gave a median tumor cell depletion of 2.2 logs (0.77-5.96). No tumor ce…
5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insu…
2022
5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote several cellular stress responses such as apoptosis, autophagy, and senescence. The action of 5-azaC is complex and can be modulated by dose, time of treatment, and co-administration with oxidants. Insulinoma is a rare pancreatic neuroendocrine tumor with limited chemotherapeutic options. In the present study, two cellular models of insulinoma were considered, namely NIT-1 and β-TC-6 mouse cells, to evaluate the effects of 5-azaC post-treatment during hydrogen peroxide-induced oxidative stress. 5-azaC attenuated the development of oxidant-induced senescent phenotype in both cell lines. No pro-apoptotic ac…
Basalt Fiber Hybridization Effects on High-Performance Sisal-Reinforced Biocomposites
2022
The increasing attention given to environmental protection, largely through specific regulations on environmental impact and the recycling of materials, has led to a considerable interest of researchers in biocomposites, materials consisting of bio-based or green polymer matrixes reinforced by natural fibers. Among the various reinforcing natural fibers, sisal fibers are particularly promising for their good mechanical properties, low specific weight and wide availability on the current market. As proven in literature by various authors, the hybridization of biocomposites by synthetical fibers or different natural fibers can lead to an interesting improvement of the mechanical properties or…
Psychobiological effects of perinatal exposure to odorants in mice. Part II: Behavioural alteration
2010
Early exposure to odorants pre-, post- or transnatally is known to. result in a decreased avoidance or increased preference for these. odorants in mammals. There are also indications that olfactory sensitivity. for these odorants can be affected. We exposed C57-Bl/6. mice of Mor23-GFP and M71-GFP lines to lyral (LY) or acetophenone. (AC), respectively, either transnatally through the water of the. mother (1*10-5 M) or postnatally in air for 1 hr per day (20 ll pure). Animals were weaned on postnatal day 20 (P20), and 3 tests were. performed:. 1) A 3-min exploration test on P20 in a rectangular arena presenting. LY and AC under a wire mesh to measure the time spent in each. half of the arena…
Alumnado femenino en las enseñanzas de artes plásticas y diseño en el sistema educativo público español 1940-2015
2018
Resumen: El presente artículo se encarga de analizar la incorporación del alumnado femenino a la enseñanza de Artes Plásticas y Diseño dentro de un marco temporal referenciado que abarca desde el final de la Guerra Civil española hasta la actualidad. El propósito es examinar la escasa evolución de la mujer dentro del sistema educativo en una etapa marcada por la adquisición de derechos. Se pretende analizar social y cualitativamente el lugar que la mujer ocupaba y ocupa en la configuración de un sistema educativo complejo, en nuestra historia reciente. En este contexto se analizan las especialidades artísticas más demandadas por el sexo femenino en las enseñanzas de bachillerato, formación …