Search results for "plastic"
showing 10 items of 7296 documents
Toward Anticancer Immunotherapeutics: Well-Defined Polymer-Antibody Conjugates for Selective Dendritic Cell Targeting
2014
This paper describes the synthesis of semitelechelic maleimide-modified N-(2-hydroxypropyl)methacrylamid) (HPMA) based polymers of narrow dispersity that can be conjugated e.g. to anti-DEC-205 antibodies affording "star-like" topologies (one antibody decorated with several polymer chains). FCS revealed a hydrodynamic diameter of R(h) = 7.9 nm and SEC narrow dispersity (1.45). Primary in vitro studies with bone marrow derived dendritic cells (DC) show higher cellular binding and uptake rates compared to control samples. Moreover, incubating these conjugates to primary splenocytes demonstrates a much higher affinity to the primary DCs than to any other immune cell population within the splee…
Evolution of anticipatory effects mediated by epigenetic changes.
2022
Abstract Anticipatory effects mediated by epigenetic changes occur when parents modify the phenotype of their offspring by making epigenetic changes in their gametes guided by information from an environmental cue. To investigate when do anticipatory effects mediated by epigenetic changes evolve in a fluctuating environment, I use an individual based simulation model with explicit genetic architecture. The model allows for the population to respond to environmental changes by evolving within generation plasticity, bet-hedging, or track the environment with genetic adaptation, in addition to the evolution of anticipatory effects. The results show that anticipatory effects evolve when the env…
Short-term impact of a Western diet on the physiology of the peripheral olfactory system
2016
Current feeding behaviors contribute to the epidemic levels of obesity and diabetes observed in Europe and worldwide. Both the quantity and the quality of ingested food are incriminated. Together with other sensory modalities, olfaction is involved in the control of food intake. Olfactory cues can influence eating behaviors, yet the nutritional status and diet can also alter olfactory abilities. Patients with metabolic disorders present impaired olfactory sensitivity which could in turn worsen their eating behaviors.Here we examined the short-term impact of a Western diet enriched in fat and sugar (High Fat High Sugar, HFHS) on the anatomy and physiology of the olfactory epithelium of postn…
Variation in egg size and offspring phenotype among and within seven Arctic charr morphs.
2022
Maternal effects have the potential to alter early developmental processes of offspring and contribute to adaptive diversification. Egg size is a major contributor to offspring phenotype, which can influence developmental trajectories and potential resource use. However, to what extent intraspecific variation in egg size facilitates evolution of resource polymorphism is poorly understood. We studied multiple resource morphs of Icelandic Arctic charr, ranging from an anadromous morph—with a phenotype similar to the proposed ancestral phenotype—to sympatric morphs that vary in their degree of phenotypic divergence from the ancestral anadromous morph. We characterized variation in egg size and…
Computational procedures for plastic shakedown design of structures
2004
The minimum volume design problem of elastic perfectly plastic finite element structures subjected to a combination of fixed and perfect cyclic loads is studied. The design problem is formulated in such a way that incremental collapse is certainly prevented. The search for the structural design with the required limit behaviour is effected following two different formulations, both developed on the grounds of a statical approach: the first one operates below the elastic shakedown limit and is able to provide a suboptimal design; the second one operates above the elastic shakedown limit and is able to provide the/an optimal design. The Kuhn–Tucker conditions of the two problems provide usefu…
Bounds on plastic strains for elastic plastic structures in plastic shakedown conditions
2007
The problem related to the computation of bounds on plastic deformations for structures in plastic shakedown condition (alternating plasticity) is studied. In particular, reference is made to structures discretized by finite elements constituted by elastic perfectly plastic material and subjected to a special combination of fixed and cyclic loads. The load history is known during the steady-state phase, but it is unknown during the previous transient phase; so, as a consequence, it is not possible to know the complete elastic plastic structural response. The interest is therefore focused on the computation of bounds on suitable measures of the plastic strain which characterizes just the fir…
Non linear analysis of 3D elastoplastic framed structures
2014
On the computational aspects of a symmetric multidomain BEM for elastoplastic analysis
2012
The symmetric boundary element method (SBEM) is applied to the elasto-plastic analysis of bodies subdivided into substructures. This methodology is based on the use of: a multidomain SBEMapproach, for the evaluation of the elastic predictor; a return mapping algorithm based on the extremal paths theory, for the evaluation of inelastic quantities characterizing the plastic behaviour of each substructure; and a transformation of the domain inelastic integrals of each substructure into corresponding boundary integrals. The elastic analysis is performed by using the SBEM displacement approach, which has the advantage of creating system equations that only consist of nodal kinematical unknowns a…
Active macro-zone approach for incremental elastoplastic-contact analysis
2013
The symmetric boundary element method, based on the Galerkin hypotheses, has found an application in the nonlinear analysis of plasticity and in contact-detachment problems, but both dealt with separately. In this paper, we want to treat these complex phenomena together as a linear complementarity problem. A mixed variable multidomain approach is utilized in which the substructures are distinguished into macroelements, where elastic behavior is assumed, and bem-elements, where it is possible that plastic strains may occur. Elasticity equations are written for all the substructures, and regularity conditions in weighted (weak) form on the boundary sides and in the nodes (strong) between cont…
Multidomain SBEM analysis of two dimensional elastoplastic-contact problems
2012
The Symmetric Boundary Element Method based on the Galerkin hypotheses has found application in the nonlinear analysis of plasticity and contact-detachment problems, but dealt with separately. In this paper we wants to treat these complex phenomena together. This method works in structures by introducing a subdivision into sub-structures, distinguished into macroelements, where elastic behaviour is assumed, and bem-elements, where it is possible for plastic strains to occur. In all the sub-structures, elasticity equations are written and regularity conditions in weighted (weak) form and/or in nodal (strong) form between boundaries have to be introduced, to attain the solving equation system.