Search results for "plastic"

Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4

2014

Abstract Cancer-initiating cells (CICs) that are responsible for tumor initiation, propagation, and resistance to standard therapies have been isolated from human solid tumors, including colorectal cancer (CRC). The aim of this study was to obtain an immunological profile of CRC-derived CICs and to identify CIC-associated target molecules for T cell immunotherapy. We have isolated cells with CIC properties along with their putative non-CIC autologous counterparts from human primary CRC tissues. These CICs have been shown to display “tumor-initiating/stemness” properties, including the expression of CIC-associated markers (e.g., CD44, CD24, ALDH-1, EpCAM, Lgr5), multipotency, and tumorigenic…

Harnessing dendritic cells in cancer.

2011

Dendritic cells (DCs) are central to the initiation of tumor-specific immune responses. However, the tumor microenvironment generates immunosuppressive cells and soluble mediators that compromise DC functions and limit the success of DC-based therapies. Progress in understanding DC metabolism in cancer is uncovering novel therapeutic targets that could restore DC capacity to prime T cells and trigger effective anticancer responses. Accumulating evidence also indicates that conventional chemo- and radiotherapy protocols can cause DC activation, enhance antigen cross-presentation, selectively eliminate immunosuppressive cells and revert the immunosuppression state caused by cancer, suggesting…

Sentinel node biopsy. A staging procedure only?

2009

Occurrence of Microplastics in Waste Sludge of Wastewater Treatment Plants: Comparison between Membrane Bioreactor (MBR) and Conventional Activated S…

2022

In this study, the presence of microplastics in the sludge of three wastewater treatment plants (WWTPs) was examined. The investigated WWTPs operated based on a conventional activated sludge (CAS) process, with (W1) or without (W2) primary clarification, and a membrane bioreactor process (MBR) (W3). The microplastics (MPs) concentration in the samples of W3 was approximately 81.1 ± 4.2 × 103 particles/kg dry sludge, whereas MPs concentrations in W1 and W2 were 46.0 ± 14.8 × 103 particles/kg dry sludge and 36.0 ± 5.2 × 103 particles/kg dry sludge, respectively. Moreover, MPs mainly consisted of fragments (66–68%) in the CAS plants, whereas the fra…

The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu

2014

Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…

Hybrid nanocomposites with ultra-low filling content by nano-coating fragmentation

2021

In the current study, a new technique for the manufacturing of polymer nanocomposites (PNCs) with ultra-low filling content (<0.05 wt%) is presented. Specifically, this method has been validated through the production of polypropylene (PP) nanocomposites with Ag nanoparticles. The presented method first consisted in a metal nano-film deposition on PP pellet substrates by a physical vapor deposition (PVD) sputtering equipment. Subsequently, a percentage of the coated pellet was mixed to uncoated ones via an injection molding machine to produce the PNC in a single step. Different mixing percentages of coated PP pellet to the uncoated ones were studied. As a result, the fragmentation of the…

Mercury and Amino Acid Content Relations in Northern Pike (Esox Lucius) in Subarctic Lakes Along a Climate-Productivity Gradient

2023

Mercury is a highly toxic element for consumers, but its relation to amino acids and physiology of wild fish is not well known. The main aim of this study was to evaluate how total mercury content (THg) of northern pike (Esox lucius) is related to amino acids and potentially important environmental and biological factors along a climate-productivity gradient of ten subarctic lakes. Linear regression between THg and sixteen amino acids content [nmol mg−1 dry weight] from white dorsal muscle of pike from these lakes were tested. Lastly, a general linear model (GLM) for age-corrected THg was used to test which factors are significantly related to mercury content of pike. There was a positive r…

Importance des voies de recyclage de la méthionine dans le contrôle de la plasticité de la composition protéique des graines

2021

International audience; La production de protéines végétales en France et en Europe nécessite de fournir des outils d’aide à la sélection de variétés de légumineuses produisant des graines de meilleure valeur nutritionnelle possible. Bien que certains constituants réputés antinutritionnels aient été réduits dans les graines des variétés de légumineuses, la fraction protéique reste à améliorer et à stabiliser pour d’avantage d’équilibre en acides aminés. Cet enjeu nécessite d’identifier les gènes contrôlant la composition protéique des graines et sa plasticité vis-à-vis de l’environnement. Une approche de génétique d’association à l’échelle du génome (GWAS) appliquée à 200 écotypes de Medica…

Risultati immediati e a lungo termine della valvuloplastica mitralica percutanea: un’esperienza di dieci anni.

2003

Trophic niche features influence microplastic ingestion in Mediterranean fish species

2022

Widespread microplastic (MP) contamination in the marine environment has raised global concern in the last decade. Scientific evidence of the adverse effects of MP on organisms is growing fast and there is urgent need to fulfil the knowledge gaps about the trophic drivers that lead to such contamination processes and resulting impacts. Fish are considered good bioindicators of MP contamination due to their easy availability, high ecological and commercial value, however our understanding of how trophic niche influences MP ingestion is limited. Here, we investigated the occurrence and abundance of MP in the gastrointestinal tract of 8 commercial fish species (Boops boops, Engraulis encrasico…