Search results for "points"

showing 10 items of 415 documents

Effects of deep cervical flexor training on pressure pain thresholds over myofascial trigger points in patients with chronic neck pain.

2012

The purpose of this study was to assess the effects of a low-load training program for the deep cervical flexors (DCFs) on pain, disability, and pressure pain threshold (PPT) over cervical myofascial trigger points (MTrPs) in patients with chronic neck pain.Thirty patients with chronic idiopathic neck pain participated in a 6-week program of specific training for the DCF, which consisted of active craniocervical flexion performed twice per day (10-20 minutes) for the duration of the trial. Perceived pain and disability (Neck Disability Index, 0-50) and PPT over MTrPs of the upper trapezius, levator scapulae, and splenius capitis muscles were measured at the beginning and end of the training…

Upper trapeziusAdultMaleManipulation Spinalmedicine.medical_specialtyPressure painAdolescentFacial NeuralgiaSeverity of Illness IndexCohort StudiesChronic neck painYoung AdultPhysical medicine and rehabilitationNeck MusclesMedicineHumansIn patientProspective StudiesTraining periodPain MeasurementMassageNeck painAnalysis of VarianceReferred painNeck Painbusiness.industryTrigger PointsMiddle AgedTreatment OutcomeSensory ThresholdsPhysical therapyFemaleChiropracticsmedicine.symptomChronic PainTraining programbusinessFollow-Up StudiesJournal of manipulative and physiological therapeutics
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Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tub…

2020

Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3&prime

Vascular Endothelial Growth Factor ACell cycle checkpoint<i>htert</i>Pharmaceutical ScienceApoptosisAnalytical Chemistrychemistry.chemical_compound0302 clinical medicineDrug DiscoveryStilbenesc-<i>myc</i>Telomerase0303 health sciences<i>vegf</i>biologyNeovascularization PathologicChemistry3′-aminocombretastatin a-4Cell cycle<i>c-Myc</i>VEGFc-MycBiochemistryChemistry (miscellaneous)030220 oncology & carcinogenesisMCF-7 CellsMolecular Medicinecytotoxicitycell cyclehTERTHT29 CellsArticleProto-Oncogene Proteins c-mycmicrotubuleslcsh:QD241-44103 medical and health sciencesStructure-Activity Relationshiplcsh:Organic chemistryMicrotubuleCell Line TumorHumansPhysical and Theoretical Chemistry030304 developmental biologyCell ProliferationCombretastatinCombretastatin A-4Cell growthOrganic ChemistryAntineoplastic Agents PhytogenicTubulintubulinCell cultureA549 Cellsbiology.proteinM Phase Cell Cycle Checkpointscombretastatin a-4Drug Screening Assays AntitumorMolecules
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Comparison of distance covered in paddle in the serve team according to performance level

2013

Although paddle is the second most practiced sport in Spain, the scientific knowledge about the players' work-load is still very low. The serve is a critical situation because the team has the opportunity to start the point attacking by approaching the net straight after the serve. However, the distance covered by the serve team still has not been studied in padel. OBJECTIVE: This study aimed to analyse the distance covered by the serve team according performance level. It was hypothesized that the server would cover more distance than his partner due to the approach to the net after the serve. Moreover, it also was hypothesized that the difference between serve and partner would be greater…

WORKRATEActivity patternsWilcoxon signed-rank testbusiness.industryComputer scienceeducationMicrosoft excelPhysical Therapy Sports Therapy and RehabilitationSample (statistics)Discount pointsMovement analysisStatisticsWorkrateMovement analysisEducación Física y DeportivaPaddleThe InternetACTIVITY PATTERNSMOVEMENT ANALYSISlcsh:Sports medicinebusinesslcsh:RC1200-1245
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Legislative reforms and market dynamics in the provision of urban water service by private contract operators in Spain

2022

Abstract This paper studies the dynamics of concentration in the Spanish market for the provision of urban water service by private contract operators in the 2000–2020 period. The market is highly concentrated. Concentration increased until 2007, at which point it started to decline when Law 30/2007 on Public Sector Contracts and Organic Law 8/2007 on Political Party Financing were passed; before rising again from 2016 onwards. This latter trend results from strategic behaviour by the two leading operators, acquiring smaller companies with a notable presence in some regional markets. Further legislative reforms aimed at safeguarding space for competition are thus proposed.

Water politicsSociology and Political Sciencebusiness.industryLegislaciómedia_common.quotation_subjectPublic sectorLegislationLegislatureManagement Monitoring Policy and LawDevelopmentSpace (commercial competition)SafeguardingDiscount pointsPrivatizationPolítica hidràulicaCompetition (economics)PoliticsMarket economyService (economics)Distribution of waterDistribució de l'aiguaBusiness and International Managementbusinessmedia_commonPrivatització
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Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy

2016

AbstractInactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while protecting normal tissues from the side effects of anti-cancer treatment. In this study, we decided to search for kinases that prevent Wip1-mediated sensitization of cancer cells, thereby interfering with efficacy of genotoxic anti-cancer drugs. To this end, we performed a flow cytometry-based screening in order to identify kinases that regulated the levels of γH2AX, which were used as readout. Another criter…

Wip1ApoptosisCell Cycle ProteinsPharmacologyMESH: G2 Phase Cell Cycle CheckpointsHistonesMESH : PhosphorylationMiceMESH : Cell Cycle ProteinsMESH: AnimalsMESH: Tumor Suppressor Protein p53MESH: HistonesKinaseTp53 mutationsMESH : Mice Transgenic3. Good healthProtein Phosphatase 2CSurvival RateMESH : Antineoplastic AgentsH2ax phosphorylationP53 activationMESH: Protein Phosphatase 2CRNA InterferenceMESH : Colorectal NeoplasmsMESH : Carrier ProteinsHistone H2axMESH: MitochondriaImmunologyHuman fibroblastsMESH: Carrier ProteinsAntineoplastic AgentsMESH: Protein-Tyrosine KinasesMESH: Protein-Serine-Threonine KinasesMESH : Cisplatin03 medical and health sciencesMESH: Cell Cycle ProteinsGenotoxic stressMESH : Protein-Tyrosine KinasesHumansMESH : HistonesAnticancer TherapyMESH: DNA DamageCisplatinMESH: HumansMESH: Phosphorylation[ SDV.BC ] Life Sciences [q-bio]/Cellular BiologyMESH : HumansMESH : Nuclear Proteins030104 developmental biologyCancer cellMESH: Antineoplastic AgentsCisplatinCarrier ProteinsMESH: Nuclear ProteinsMESH : ApoptosisDna-damage response0301 basic medicineCancer ResearchMESH: Caspase 3MESH : Caspase 3PhosphorylationCytotoxicityMESH : DNA DamageSensitizationmedicine.diagnostic_testCaspase 3Nuclear ProteinsProtein-Tyrosine KinasesMESH : Survival RateMitochondriaG2 Phase Cell Cycle CheckpointsWee1medicine.anatomical_structureMESH : Protein Phosphatase 2COriginal ArticleMESH : MitochondriaColorectal Neoplasmsmedicine.drugMESH : Protein-Serine-Threonine KinasesMESH: Cell Line TumorMESH: Survival RateMESH: Mice TransgenicMESH: RNA InterferencePhosphataseMice Transgenic[SDV.BC]Life Sciences [q-bio]/Cellular BiologyBiologyProtein Serine-Threonine KinasesFlow cytometryCellular and Molecular NeuroscienceCell Line TumorMESH : MicemedicineAnimalsMESH: MiceMESH : Cell Line TumorMESH: ApoptosisCell BiologyMESH : Tumor Suppressor Protein p53MESH: CisplatinCancer researchbiology.proteinMESH : AnimalsMESH : G2 Phase Cell Cycle CheckpointsMESH : RNA InterferenceTumor Suppressor Protein p53MESH: Colorectal NeoplasmsDNA DamageCell Death & Disease
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The Acquisition of Professional Expertise—a challenge for educational research

1997

This article examines the acquisition of professional expertise from the educational viewpoint and outlines emerging approaches to research on expertise. The starting points are the need to reflect the nature and content of expertise in the changing world and the aim to understand the preconditions for integrating the viewpoints of working life and education in developing prerequisities for expertise in educational contexts. The section after the Introduction briefly reviews how expertise has been conceptualized in recent research. The next section deals with the role of higher education in developing expertise from the viewpoint of constructivist approaches in research on learning. Then cu…

Working lifeEducational researchHigher educationbusiness.industryPedagogyEngineering ethicsPsychologybusinessViewpointsCompetence (human resources)Work experienceEducationProfessional expertiseScandinavian Journal of Educational Research
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Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

2012

PMCID: PMC3494587

X-Box Binding Protein 1Proteasome Endopeptidase ComplexProgrammed cell deathXBP1CD3 ComplexMAP Kinase Signaling SystemRNA SplicingT-LymphocytesT cellDown-RegulationApoptosisRegulatory Factor X Transcription FactorsUbiquitin-Activating EnzymesProtein Serine-Threonine KinasesBiologyArginineLymphocyte ActivationAutophagy-Related Protein 7Jurkat cellsJurkat CellsEndoribonucleasesAutophagymedicineHumansMolecular BiologyCell ProliferationTOR Serine-Threonine KinasesAutophagyMembrane ProteinsCell BiologyBECN1Endoplasmic Reticulum StressG1 Phase Cell Cycle CheckpointsBasic Research Paper3. Good healthCell biologyDNA-Binding Proteinsmedicine.anatomical_structureCytoprotectionApoptosisUnfolded protein responseBeclin-1MitogensApoptosis Regulatory ProteinsLysosomesProto-Oncogene Proteins c-aktTranscription FactorsAutophagy
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Cytotoxicity and modes of action of three naturally occurring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitiv…

2014

Abstract Background Resistance of cancer to chemotherapy remains a challenging issue for scientists as well as physicians. Naturally occurring xanthones possess a variety of biological activities such as anti-inflammatory, anti-bacterial, and anti-cancer effects. The present study was aimed at investigating the cytotoxicity and the modes of action of three naturally occurring xanthones namely, morusignin I (1), 8-hydroxycudraxanthone G (2) and cudraxanthone I (3) against a panel of nine cancer cell lines, including various sensitive and drug-resistant phenotypes. Methods The cytotoxicity of the compounds was determined using a resazurin reduction assay, whereas the caspase-Glo assay was use…

XanthonesPharmaceutical ScienceApoptosisCaspase 8Flow cytometryCell Line TumorNeoplasmsDrug DiscoverymedicineHumansCytotoxicityCaspaseMembrane Potential MitochondrialPharmacologybiologymedicine.diagnostic_testPlant ExtractsCancerCell Cycle CheckpointsHep G2 CellsCell cyclemedicine.diseaseAntineoplastic Agents PhytogenicDrug Resistance MultipleComplementary and alternative medicineDrug Resistance NeoplasmApoptosisCell cultureCaspasesImmunologybiology.proteinCancer researchMolecular MedicineGarciniaPhytotherapyPhytomedicine
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Amerikāņu un meksikāņu viedoklis par „amerikāņu sapni”

2017

Bakalaura darba tēma ir uzzināt Amerikāņu un Meksikāņu viedokļus par "Amerikāņu sapni", kuri atspoguļojas filmās, kā arī, to kā Amerikāņu sapnis ir uztverts filmās "Ziemeļi" (1984) un "Tiekšanās pēc laimes" (2006). Galvenais uzdevums bija analizēt filmas, lai redzētu kā Amerikāņu sapnis tiek panākts abām nācijām. Papildus, šim uzdevumam tika arī uzsvērti Amerikāņu sapņa elementi, kas raksturo šo fenomenu. Pētījumā viens no uzdevumiem bija atrast Amerikāņu sapnim pašu piemērotāko definīciju un elementus kas to veido. Tas tika paveikts lasot dažādu autoru grāmatas un rakstus, kuri diskutē par šo tēmu. Bakalaura darbā tika izmantotas pētīšanas metodes, tādas kā, bibliotēkas pētījumi un filmu, …

ZiemeļiPoints of viewValodniecībaThe Pursuit of HappynessAmerikāņi un meksikāņiThe American Dream
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Rotation Forms and Local Hamiltonian Monodromy

2017

International audience; The monodromy of torus bundles associated with completely integrable systems can be computed using geometric techniques (constructing homology cycles) or analytic arguments (computing discontinuities of abelian integrals). In this article, we give a general approach to the computation of monodromy that resembles the analytical one, reducing the problem to the computation of residues of polar 1-forms. We apply our technique to three celebrated examples of systems with monodromy (the champagne bottle, the spherical pendulum, the hydrogen atom) and to the case of non-degenerate focus-focus singularities, re-obtaining the classical results. An advantage of this approach …

[ MATH ] Mathematics [math]Pure mathematicsIntegrable systemFOCUS-FOCUS SINGULARITIESmath-phFOS: Physical sciencesDynamical Systems (math.DS)Homology (mathematics)01 natural sciencesSingularityMathematics::Algebraic Geometrymath.MPSYSTEMS0103 physical sciencesFOS: Mathematics0101 mathematicsAbelian groupMathematics - Dynamical Systems[MATH]Mathematics [math]010306 general physicsMathematics::Symplectic GeometryMathematical PhysicsMathematicsNEIGHBORHOODS[PHYS]Physics [physics][ PHYS ] Physics [physics]010102 general mathematicsSpherical pendulumStatistical and Nonlinear PhysicsTorusMathematical Physics (math-ph)37JxxMonodromyStatistical and Nonlinear Physics; Mathematical PhysicsGravitational singularityPOINTSmath.DS
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