Search results for "poor"
showing 10 items of 157 documents
Quantitative Structure-Antioxidant Activity Models of Isoflavonoids: A Theoretical Study
2015
Seventeen isoflavonoids from isoflavone, isoflavanone and isoflavan classes are selected from Dalbergia parviflora. The ChEMBL database is representative from these molecules, most of which result highly drug-like. Binary rules appear risky for the selection of compounds with high antioxidant capacity in complementary xanthine/xanthine oxidase, ORAC, and DPPH model assays. Isoflavonoid structure-activity analysis shows the most important properties (log P, log D, pKa, QED, PSA, NH + OH ≈ HBD, N + O ≈ HBA). Some descriptors (PSA, HBD) are detected as more important than others (size measure Mw, HBA). Linear and nonlinear models of antioxidant potency are obtained. Weak nonlinear relationship…
The re Structure of Cyclopropane
2000
A long-standing controversy regarding the re structure of cyclopropane is resolved by performing high-level quantum chemical calculations and analyzing the experimental rotational constants for C3H6 and C3H4D2 augmented by calculated vibrational corrections. For the latter, a least-squares fit yields the following set of parameters: re (CC) = 1.5030(10) A, re(CH) = 1.0786(10) A, and αe(HCH) = 114.97(10)°, which compare favorably with both the pure computational result obtained at the CCSD(T)/cc-pVQZ level as well as an earlier estimate of the re structure of cyclopropane based on analysis of gas-phase electron diffraction data. Our results are in rather poor agreement with a structure base…
High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions
2018
Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance the dissolution of poorly water-soluble drug compounds. The stabilizers exert their action through electrostatic or steric interactions, however, the molecular requirements of stabilizing agents have not been studied extensively. Here, four structurally related amphiphilic Janus-dendrimers were synthesized and screened to determine the roles of different macromolecular domains on the stabilization of drug crystals. Physical interaction and nanomilling experiments have substantiated that Janus-dendrimers with fourth gen…
A Proposal to Compare Consistently the Inequality Among the Poor
2013
A poverty index should be sensitive to the number of poor people, the extent of the shortfall of the poor, and the inequality among the poor. A difficulty arises when inequality among the poor needs to be assessed. The inequality may be analyzed in terms of either incomes or gaps. Depending on what side we focus on, the inequality level comparisons may be contradictory. This paper proposes a reinterpretation of the inequality component involved in the decompositions of well-known poverty indices. The alternative indices we introduce measure equally the income and gap inequality among the poor. The comparisons in inequality as measured by these indices are then independent of the viewpoint. …
HIV-Infected Children and Nutrition: The Friend and The Foe
2019
The impact of nutrition on HIV-infected children has been evaluated in multiple studies. Our review of the current trends of nutrition-related studies revealed that the focus has moved from simply the disease consequences of HIV to ensuring that antiretroviral therapy-treated children are well nourished to ensure growth and development. This update aims to present the state of the art regarding nutrition of HIV-infected children and the real potential for nutrition to serve as a dynamic therapy in this group. Recent World Health Organization reports indicate that the HIV/AIDS disease is curbing in incidence worldwide despite the high 1.8 million children, less than 15 years, reported in 201…
La decadenza nel diritto del lavoro tra vicende traslative e fattispecie interpositorie
2020
L’art. 32 della legge n. 183/2010 ha sollevato molteplici questioni applicative legate alla sua infelice formulazione. Il saggio analizza il controverso perimetro applicativo del comma 4, lett. c) e d), inerenti rispettivamente la cessione del contratto di lavoro avvenuta ai sensi dell’art. 2112 c.c. e i casi in cui si chieda la costituzione o l’accertamento di un rapporto di lavoro in capo a un soggetto diverso dal titolare del contratto. L’Autore fornisce le coordinate per una corretta interpretazione, opportunamente restrittiva, delle previsioni decadenziali alla luce del dato letterale e del diritto dell’Unione europea.
Segregati e connessi. ‘Nuovi migranti’: profilo sociolinguistico e costruzione dei dati
2021
Recent migrations show unprecedented characteristics in terms of migratory routes, migrants’ individual profiles and needs (also linguistic) and the conditions of isolation and segregation in the arrival contexts.
Social Services in the region of Valencia: the current ‘Valencian model’ and a new set of ideas for the construction of a model of social rights
2015
Introducción: La aprobación de la LRSAL* presenta un panorama de cambio para los Sistemas de Servicios Sociales de España, sobre todo en lo atingente a lo local. Un grupo de expertos/as de la Comunitat Valenciana ha trabajado esta circunstancia como una oportunidad positiva. Material y Métodos: Mediante el análisis documental y el debate de la realidad del sector realizado por este grupo de expertos/as, se ha desgranado el modelo actual de los servicios sociales municipales valencianos, se ha reflexionado en sus diferencias con los modelos basados en leyes de tercera generación, y a partir de ello, se atreve a proponer las bases para la construcción de un nuevo modelo del Sistema Valenciano…
La Valle dei Templi in epoca medioevale. Caratterizzazione antropologica e paleopatologica delle sepolture antistanti in Tempio della Concordia
2021
Riassunto ― Il lavoro presenta i risultati delle analisi bio-archeologiche effettuate su resti scheletrici umani rinvenuti in quattordici sepolture di epoca medioevale rinvenute nel Parco Archeologico della Valle dei Templi di Agrigento (Sicilia). L’obiettivo è stato l’acquisizione delle informazioni necessarie per la ricostruzione del profilo biologico di ciascun individuo, al fine di determinarne il sesso, la stima dell’età biologica alla morte, la stima della statura e la valutazione delle patologie e degli indicatori di stress occupazionale mediante le correnti metodologie e tecniche diagnostiche di tipo antropologico. Sebbene il cattivo stato di conservazione di alcuni individui non ne…
The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir
2019
Chitosan is object of pharmaceutical research as a candidate permeability enhancer. However, chitosan was recently shown to reduce the oral bioavailability of acyclovir in humans. The effect of chitosan on two processes determining the oral bioavailability of acyclovir, bioaccessibility and intestinal absorption, was now investigated. Acyclovir's bioaccessibility was studied using the dynamic TNO gastro-Intestinal Model (TIM-1). Four epithelial models were used for permeability experiments: a Caco-2 cell model in absence and presence of mucus and both rat and porcine excised intestinal segments. Study concentrations of acyclovir (0.8 g/l) and chitosan (1.6 g/l and 4 g/l) were in line with t…