Search results for "poor"
showing 10 items of 157 documents
Cilium induction triggers differentiation of glioma stem cells
2020
Glioblastoma multiforme (GBM) possesses glioma stem cells (GSCs) that promote self-renewal, tumor propagation, and relapse. GBM has a poor prognosis, and currently, there are no curative options exist. Understanding the mechanisms of GSCs self-renewal can offer targeted therapeutic interventions. However, insufficient knowledge of the fundamental biology of GSCs is a significant bottleneck hindering these efforts. Here, we show that patient-derived GSCs recruit an elevated level of proteins that ensure the temporal cilium disassembly, leading to suppressed ciliogenesis. Depleting the cilia disassembly complex components at the ciliary base is sufficient to induce ciliogenesis in a subset of…
Marx y Engels y la división sexual del trabajo en la familia: ambigüedades, equívocos y vacíos teóricos
2018
Dada la importante influencia de Marx y Engels en el análisis de la estructura social, no sorprende el notable impacto de su obra en el estudio del papel de la mujer en la familia. Sin embargo, su herencia en este ámbito sociológico ha dado lugar a interpretaciones muy polarizadas. Este artículo quiere aportar algo de luz evidenciando las contradicciones del marxismo al estudiar el papel de la mujer en la familia. Para ello se comparan las contribuciones de Marx y Engels para calibrar posibles diferencias en las posturas de dos autores que en otros ámbitos han presentado un pensamiento muy homogéneo. Los resultados obtenidos permiten afirmar que, a pesar de su innegable influencia en el pen…
Le séminaire de lectura aux cours universitaires. Une proposition: "Le bal", de Irène Némirovsky
2017
Recientes estudios han demostrado el escaso hábito lector de los estudiantes universitarios españoles, así como la falta de solidez de su competencia literaria. Estas limitaciones ponen de relieve la necesidad de la lectura guiada, una propuesta didáctica que suele relacionarse con los niveles iniciales de la enseñanza, pero cuya necesidad se hace cada vez más imperiosa en la educación superior. En este contexto, el presente artículo apuesta por el seminario de lectura como una de las estrategias más efectivas, a la par que estimulantes, para acompañar a los universitarios en ese aprendizaje. Como sugerencia para el docente, desarrollamos un ejemplo a partir de El baile, de Irène Némirovsky…
Intratympanic gentamicin: a 1-day protocol treatment for unilateral Meniere's disease
2006
Abstract Purpose The objective of this study was to assess the usefulness of low-dose intratympanic gentamicin administration in patients with Meniere's disease (MD). Materials and Methods We carried out a retrospective review of the charts of 55 patients with definite MD in accordance with the AAO-HNS (American Academy of Otolaryngology–Head and Neck Surgery) Diagnostic Scale who were treated at Gruppo Otologico (Piacenza, Rome, Italy). The treatment protocol consisted of 3 intratympanic injections of gentamicin at a 12-hour interval between each administration. Results Results were resumed in accordance with AAO-HNS criteria and showed complete control of vertigo spells in 60% (class A), …
Adherence to omalizumab: A multicenter “real-world” study
2020
Background: Adherence to medications is crucial in patients with severe asthma in light of the negative clinical impact and costs of non-adherence. Adherence to omalizumab has not been well studied in real-world settings. The aim of this study was to assess adherence to omalizumab and evaluate treatment effectiveness in relation to adherence. Methods: This was a retrospective, observational, and multicenter real-world study. Omalizumab dose, timing of administration, and duration of treatment ( 4 years) were analyzed. Adherence was evaluated by examining rates of expected and missing doses. Good adherence (10% doses missed) were determined. For effectiveness in relation to adherence of omal…
Individuality in the Early Number Skill Components Underlying Basic Arithmetic Skills
2018
Early number skills underlie success in basic arithmetic. However, very little is known about the skill profiles among children in preprimary education and how the potential profiles are related to arithmetic development. This longitudinal study of 440 Finnish children in preprimary education (mean age: 75 months) modeled latent performance-level profile groups for the early number skill components that are proposed to be key predictors of arithmetic (symbolic number comparison, mapping, and verbal counting skills). Based on three assessment time points (September, January, and May), four profile groups were found: the poorest-performing (6%), low-performing (16%), near-average-performing (…
Individuality in the Early Number Skill Components Underlying Basic Arithmetic Skills.
2018
Early number skills underlie success in basic arithmetic. However, very little is known about the skill profiles among children in preprimary education and how the potential profiles are related to arithmetic development. This longitudinal study of 440 Finnish children in preprimary education (mean age: 75 months) modeled latent performance-level profile groups for the early number skill components that are proposed to be key predictors of arithmetic (symbolic number comparison, mapping, and verbal counting skills). Based on three assessment time points (September, January, and May), four profile groups were found: the poorest-performing (6%), low-performing (16%), near-average-performing (…
Ergonomic Risk Assessment of Dental Students—RULA Applied to Objective Kinematic Data
2021
Musculoskeletal disorder (MSD) is already prevalent in dental students despite their young age and the short duration of dental practice. The current findings state that the causes of MSD are related to posture during dental work. This study aims to investigate the ergonomic risk of dental students. In order to analyze the ergonomic risk of dental students, 3D motion analyses were performed with inertial sensors during the performance of standardized dental activities. For this purpose, 15 dental students and 15 dental assistant trainees (all right-handed) were measured in a team. Data were analyzed using the Rapid Upper Limb Assessment (RULA), which was modified to evaluate objective data.…
Sleep disturbances in tension-type headache and migraine
2017
Current research into the pathogenesis of tension-type headache (TTH) and migraine is focused on altered nociceptive pain processing. Among the potential factors that influence sensitization mechanisms, emotional stress, depression, or sleep disorders all have an essential role: they increase the excitability of nociceptive firing and trigger hyperalgesic responses. Sleep disturbances and headache disorders share common brain structures and pathogenic mechanisms and TTH, migraine, and sleep disturbances often occur together; for example, 50% of individuals who have either TTH or migraine have insomnia. Moreover, insomnia and poor sleep quality have been associated with a higher frequency an…
Maternal profile according to Mediterranean diet adherence and small for gestational age and preterm newborn outcomes
2020
AbstractObjective:The objective was to evaluate maternal Mediterranean diet (MD) pattern adherence during pregnancy and its association with small for gestational age (SGA) and preterm birth. A secondary objective of the current study was to describe the sociodemographic, lifestyle and obstetric profile of the mothers studied as well as the most relevant paternal and newborn characteristics.Design:The current study is a two-phase retrospective population-based study of maternal dietary habits during pregnancy and their effect on newborn size and prematurity. The descriptive first phase examined maternal dietary habits during pregnancy along with the maternal sociodemographic, lifestyle and …