Search results for "post"
showing 10 items of 6213 documents
The Extracellular δ-Domain is Essential for the Formation of CD81 Tetraspanin Webs
2014
AbstractCD81 is a ubiquitously expressed member of the tetraspanin family. It forms large molecular platforms, so-called tetraspanin webs that play physiological roles in a variety of cellular functions and are involved in viral and parasite infections. We have investigated which part of the CD81 molecule is required for the formation of domains in the cell membranes of T-cells and hepatocytes. Surprisingly, we find that large CD81 platforms assemble via the short extracellular δ-domain, independent from a strong primary partner binding and from weak interactions mediated by palmitoylation. The δ-domain is also essential for the platforms to function during viral entry. We propose that, ins…
(A,B) In vivo GCaMP6f signals recorded in layers M1, M5 and M9/10 of Mi1 (A) and Tm3 (B) neurons, before (blue, green) and after (gray, red) applicat…
2019
Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specifi…
Long-term strength and balance training prevents mobility decline among community-dwelling people aged 75 and older
2016
High functional capacity of muscle strength and balance in older persons promotes independent mobility and prevents functional decline below the disability threshold. This dissertation explored the effects of strength and balance training (SBT) as part of a multimodal geriatric intervention on physical functioning and health-related factors associated with training participation in a community-dwelling population aged 75 years and over. This study is a part of the Geriatric Multidisciplinary Strategy for the Good Care of the Elderly (GeMS) project conducted from 2004 to 2007 in Kuopio, Finland. Participants were randomized into an intervention (n=339) and control group (n=312). The individu…
Accumulation of sensory difficulties predicts fear of falling in older women
2013
Objectives: To explore whether the accumulation of sensory difficulties predicts fear of falling (FOF), and whether the traits correlate with each other regardless of familial factors. Methods: Self-reported hearing, vision and balance difficulties, and FOF were assessed using structured questionnaires at the baseline and after a 3-year follow-up in 63- to 76-year-old women (n = 434). Results: Among the women without FOF at baseline (n = 245), 41% reported FOF at follow-up. Increasing numbers of sensory difficulties at baseline predicted higher incidence of FOF. The relationship between accumulated sensory difficulties and FOF was not mediated by familial factors. Discussion: The accumulati…
To See It All / To Hear It All: Michael Gira's Songs of Experience
2018
Between 2012 and 2016, the American experimental rock band Swans, led by the vocalist, multi-instrumentalist and visionary Michael Gira, released a monumental trilogy of albums comprising The Seer, To Be Kind, and The Glowing Man. The lyrics on all of them portray Gira’s own search for identity, with the result being a peculiar version of spirituality that is both philosophically religious and ideologically anti-religious. Forced to exist in the hostile, incomprehensible and spiritually-barren reality, the artist finds himself alienated in the state of the end of childhood and loss of innocence. In other words, he locates his identity in this final stage of spirituality and primal religion …
Pēcoperācijas perioda izvērtējums pēc radzenes transplantācijas vispārējā anestēzijā
2020
Bakalaura darba tēma ir “Pēcoperācijas perioda izvērtējums pēc radzenes transplantācijas vispārējā anestēzijā”. Darba tēmas aktualitāte ir tajā, ka radzenes transplantācijas operācijas visā pasaulē un Latvijā tiek veiktas arvien vairāk, tāpēc ir būtiski novērtēt pēcoperācijas periodu pēc šīm operācijām, lai izvērtēt aprūpes procesu, pacientu sūdzības un dokumentācijas kvalitāti un nepieciešamības gadījumā veikt uzlabojums. Darba mērķis ir izvērtēt pēcoperācijas periodu pacientam pēc radzenes transplantācijas operācijas vispārējā anestēzijā. Bakalaura darba mērķa saniegšanai autore izvirzija sekojošus darba uzdevumus - apkopot un analizēt zinātnisko literatūru par radzenes transplantāciju un…
Postural entrainment by vocal effort in singing and speech
2009
This study assesses the interaction of the postural control system and the production of expressive vocal behavior during speech and singing. In particular, we focus on the head, whose motions have been implicated for both postural control and spoken language production. How does head motion behavior simultaneously serve posture control and linguistic communication during vocalization? This study examines the interaction of these two subsystems by measuring the effects of different levels of vocal effort (loudness) on speech and singing. We show that as vocalizations becomes louder the correspondence between measures of head motion and speech acoustics become less complex and better coordin…
Anticipatory Postural Adjustments and kinematic arm features when postural stability is manipulated
2018
International audience; Beyond the classical paradigm that presents the Anticipatory Postural Adjustments (APAs) as a manner to create forces that counteract disturbances arising from the moving segment during a pointing task, there is a controversial discussion about the role APAs to facilitate the movement and perform a task accurately. In addition, arm kinematics features are classically used to infer the content of motor planning for the execution and the control of arm movements, The present study aimed to disentangle the conflicting role of APAs during an arm-pointing task in which the subjects reach a central diode that suddenly turns on, while their postural stability was manipulate…
Anatomical and electrophysiological study of the vomeronasal circuits: Amygdaloid response to odours and pheromones
2017
Rodents detect information concerning the world around them mainly through two chemosensory systems: the olfactory and the vomeronasal systems. In order to develop an appropriate behavioural response to their environment, these systems exhibit both functional and physiological convergence. Further understanding of the organization and function of the olfactory systems would allow us to comprehend how their information is integrated in the brain. In a first approach we performed a thorough analysis of the connections of key structures involved in the processing of vomeronasal information: the medial (Me) and the posteromedial cortical (PMCo) amygdaloid nucleus. Then, we enquire the populatio…
Practicing Ballot Secrecy: Postal Voting and the Witness Requirement at the 2019 Finnish Elections
2021
Electoral rights belong to the core of citizenship in democratic nation-states. Voting, then, represents an actualization of the relationship between the citizen and the political community. For citizens living outside the country in which they are eligible to vote, voting signifies a rare institutional connection to the country of origin. The aim of this article is to explore the introduction of the postal vote, a new form of voting for external voters at Finnish elections, from the grassroots perspective. The study focuses on how a central policy concern, safeguarding ballot secrecy, was resolved in the policy implementation by the witness requirement, and how the individual voters subseq…